Protein Bag1

URN	urn:agi-llid:573
Total Entities	0
Connectivity	454
Name	Bag1
Description	BCL2-associated athanogene
Notes	The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]

GO Molecular Function	receptor signaling protein activity
	chaperone binding
	phosphoprotein binding

GO Cellular Component	cytoplasm
	cytosol
	perinuclear region of cytoplasm
	mitochondrion
	nucleus

GO Biological Process	neuron differentiation
	cell surface receptor signaling pathway
	apoptotic process
	negative regulation of apoptotic process
	negative regulation of motor neuron apoptotic process
	positive regulation of neuron apoptotic process
	response to drug
	response to lithium ion
	response to organic cyclic compound
	response to nicotine
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of protein phosphorylation
	chaperone cofactor-dependent protein refolding
	protein localization to mitochondrion

Pathway	Mitochondrial Protein Transport
	Protein Folding
	Overview of Mitochondrial Dysfunction in Alzheimer's Disease
	Mitochondrial Respiratory Chain Dysfunction in Alzheimer's Disease
	Mitochondria Enlargement and Apoptosis in Alzheimer's Disease
	Class II Mutations Cause CFTR Misfolding and Degradation in Cystic Fibrosis
	Proteins Involved in Pathogenesis of Glioma
	ER Stress (Unfolded Protein Response)
	chaperone mediated autophagy pathway

Group	neuron differentiation
	cell surface receptor signaling pathway
	receptor signaling protein activity
	apoptotic process
	negative regulation of apoptotic process
	negative regulation of motor neuron apoptotic process
	positive regulation of neuron apoptotic process
	response to drug
	response to lithium ion
	response to organic cyclic compound
	response to nicotine
	positive regulation of transcription from RNA polymerase II promoter
	negative regulation of protein phosphorylation
	chaperone cofactor-dependent protein refolding
	protein localization to mitochondrion
	chaperone binding
	phosphoprotein binding
	cytoplasm
	cytosol
	perinuclear region of cytoplasm
	mitochondrion
	nucleus
	Secreted proteins

Cell Localization	Nucleus
	Cytoplasm

Alias	HAP
	BAG-1
	RAP46
	RP11-326F20.2
	BAG family molecular chaperone regulator 1
	Bcl-2-binding protein
	receptor-associated protein, 46-KD
	Bcl-2 associating athanogene-1 protein
	glucocortoid receptor-associated protein RAP46
	RP23-28I8.3
	bcl-2-associated athanogene 1
	hsp70/hsc70 associating protein
	BCL2-associated athanogene I
	Glucocorticoid receptor-associated protein RAP46
	HAP46
	hsp70/hsc70-associating protein
	OTTHUMP00000021199
	OTTMUSP00000006964
	Bcl2-associated athanogene 1 isoform 1L
	BAG-1Ms
	BCL2-associated athanogene isoform 1L
	BCL2-associated athanogene 1
	BAG I
	BAG1
	BAG-1M
	BAG-family molecular chaperone regulator I
	BAG-family molecular chaperone regulator-1
	BCL-2 binding athanogene I
	BCL-2 binding athanogene-1
	BCL2-associated athanogene
	BAG1_HUMAN

Mouse chromosome position	4

OMIM ID	601497

Rat chromosome position	5q22

Hugo ID	937

Human chromosome position	9p12

Homologene ID	3190

MGI ID	108047

RGD ID	1305203

MedScan ID	573