Elsevier Inc. CMA targets cathepsins LysHspa8 Lamp2a multimer Bag1 ---> ATP ADP ---> ATP Hsp8a factors ADP-bound Hspa8 state ATP-bound Hspa8 state Gfap dissoc ---- P-Gfap Eef1a1 Gfap Lamp2a dissoc KFERQ motif ---- Lamp2 Eef1a1 ---- P-Gfap Bag1 Hspa8 ---- KFERQ motif Gfap ---- Lamp2a multimer Dnajb1 Hsp8a factors ---- Hspa8 ATP ---- Hspa8 ATP ADP ---- Hspa8 ADP Dnajb1 ---> ADP ATP ---> ADP Hspa8 Lamp2 KFERQ motif ---> KFERQ translocated CMA target degradation cathepsins ---> CMA targets KFERQ motif KFERQ translocated Gfap dissoc P-Gfap