| URN | urn:agi-llid:2671 |
|---|---|
| Total Entities | 0 |
| Connectivity | 182 |
| Name | Gfer |
| Description | growth factor, augmenter of liver regeneration |
| Notes | The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| thiol oxidase activity | |
| protein disulfide oxidoreductase activity | |
| growth factor activity | |
| flavin adenine dinucleotide binding |
| GO Cellular Component | extracellular region |
|---|---|
| mitochondrial intermembrane space | |
| cytoplasm | |
| mitochondrion |
| GO Biological Process | spermatogenesis |
|---|---|
| cell proliferation | |
| oxidation-reduction process | |
| protein targeting to mitochondrion | |
| cellular protein metabolic process |
| Pathway | imtochondrial protein import pathway |
|---|---|
| mitochondrial protein import pathway |
| Group | GF |
|---|---|
| spermatogenesis | |
| cell proliferation | |
| oxidation-reduction process | |
| oxidoreductase activity | |
| thiol oxidase activity | |
| protein disulfide oxidoreductase activity | |
| protein targeting to mitochondrion | |
| cellular protein metabolic process | |
| growth factor activity | |
| flavin adenine dinucleotide binding | |
| extracellular region | |
| mitochondrial intermembrane space | |
| cytoplasm | |
| mitochondrion | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 2671 |
|---|---|
| 11692 | |
| 27100 |
| Cell Localization | Extracellular |
|---|---|
| Cytoplasm | |
| Mitochondrion intermembrane space | |
| Secreted |
| GO ID | 0050660 |
|---|---|
| 0008083 | |
| 0015035 | |
| 0016972 | |
| 0008283 | |
| 0044267 | |
| 0006626 | |
| 0007283 | |
| 0005737 | |
| 0005576 | |
| 0005758 | |
| 0005739 | |
| 0016491 | |
| 0055114 |
| Alias | ALR |
|---|---|
| HPO | |
| HSS | |
| ERV1 | |
| HPO1 | |
| HPO2 | |
| HERV1 | |
| FAD-linked sulfhydryl oxidase ALR | |
| ERV1 homolog | |
| hepatopoietin protein | |
| erv1-like growth factor | |
| hepatic regenerative stimulation substance | |
| MNCb-0663 | |
| augmenter of liver regeneration | |
| growth factor, erv1 homolog | |
| growth factor, erv1-like (augmenter of liver regeneration) | |
| HPO I | |
| hepatopoietin | |
| hepatic regenerative stimulating substance | |
| truncated augmenter of liver regeneration | |
| growth factor, erv1 -like (augmenter of liver regeneration) | |
| Gfer | |
| growth factor, augmenter of liver regeneration | |
| growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration) | |
| growth factor, erv1 -like |
| Mouse chromosome position | 17 12.48 cM |
|---|
| OMIM ID | 600924 |
|---|---|
| 613076 |
| Rat chromosome position | 10q12 |
|---|
| Hugo ID | 4236 |
|---|
| Human chromosome position | 16p13.3-p13.12 |
|---|
| Swiss-Prot Accession | P55789 |
|---|---|
| P56213 | |
| Q63042 | |
| Q8CIF8 | |
| Q9JJE6 | |
| Q53YM6 | |
| Q8TAH6 | |
| Q9H290 | |
| Q9UK40 |
| PIR ID | I80184 |
|---|
| Unigene ID | Hs.27184 |
|---|---|
| Mm.28124 | |
| Rn.11039 |
| KEGG ID | hsa:2671 |
|---|---|
| mmu:11692 | |
| rno:27100 |
| Swiss-Prot ID | ALR_MOUSE |
|---|---|
| ALR_RAT | |
| ALR_HUMAN |
| EC Number | 1.8.3.2 |
|---|
| Ensembl ID | ENSG00000127554 |
|---|---|
| ENSP00000248114 | |
| ENST00000248114 | |
| ENSMUSG00000040888 | |
| ENSMUSP00000049186 | |
| ENSMUST00000046839 | |
| ENSRNOG00000013370 | |
| ENSRNOP00000017917 | |
| ENSRNOT00000017917 |
| Homologene ID | 55884 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 107757 |
|---|
| RGD ID | 61845 |
|---|
| MedScan ID | 2671 |
|---|