| URN | urn:agi-llid:51100 |
|---|---|
| Total Entities | 0 |
| Connectivity | 133 |
| Name | Sh3glb1 |
| Description | SH3-domain GRB2-like endophilin B1 |
| Notes | This gene encodes a SRC homology 3 domain-containing protein. The encoded protein interacts with the proapoptotic member of the Bcl-2 family, Bcl-2-associated X protein (Bax) and may be involved in regulating apoptotic signaling pathways. This protein may also be involved in maintaining mitochondrial morphology. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] |
| GO Molecular Function | lysophosphatidic acid acyltransferase activity |
|---|---|
| lipid binding | |
| protein homodimerization activity | |
| fatty acid binding |
| GO Cellular Component | membrane |
|---|---|
| Golgi membrane | |
| mitochondrial outer membrane | |
| mitochondrial envelope | |
| protein complex | |
| cytoplasm | |
| Golgi apparatus | |
| cytosol | |
| endoplasmic reticulum | |
| mitochondrion |
| GO Biological Process | phospholipid biosynthetic process |
|---|---|
| phosphatidic acid biosynthetic process | |
| positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | |
| apoptotic process | |
| positive regulation of protein oligomerization | |
| 'de novo' posttranslational protein folding | |
| protein oligomerization |
| Pathway | mitochondria dynamics pathway |
|---|
| Group | Aromatic amino acid metabolism |
|---|---|
| Branched amino acid metabolism | |
| phospholipid biosynthetic process | |
| phosphatidic acid biosynthetic process | |
| positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway | |
| apoptotic process | |
| positive regulation of protein oligomerization | |
| lysophosphatidic acid acyltransferase activity | |
| 'de novo' posttranslational protein folding | |
| protein oligomerization | |
| lipid binding | |
| protein homodimerization activity | |
| fatty acid binding | |
| membrane | |
| Golgi membrane | |
| mitochondrial outer membrane | |
| mitochondrial envelope | |
| protein complex | |
| cytoplasm | |
| Golgi apparatus | |
| cytosol | |
| endoplasmic reticulum | |
| mitochondrion |
| LocusLink ID | 51100 |
|---|---|
| 54673 | |
| 292156 |
| Cell Localization | Cytoplasm |
|---|---|
| Golgi apparatus membrane | |
| Mitochondrion outer membrane |
| GO ID | 0005504 |
|---|---|
| 0042171 | |
| 0042803 | |
| 0051084 | |
| 0006915 | |
| 0006654 | |
| 1900740 | |
| 0032461 | |
| 0051259 | |
| 0000139 | |
| 0005737 | |
| 0005741 | |
| 0043234 | |
| 0008289 | |
| 0008654 | |
| 0005794 | |
| 0005829 | |
| 0005783 | |
| 0016020 | |
| 0005740 | |
| 0005739 |
| Alias | Bif-1 |
|---|---|
| CGI-61 | |
| PPP1R70 | |
| dJ612B15.2 | |
| endophilin-B1 | |
| Bax-interacting factor 1 | |
| SH3-containing protein SH3GLB1 | |
| SH3 domain-containing GRB2-like protein B1 | |
| protein phosphatase 1, regulatory subunit 70 | |
| AA409932 | |
| AI314629 | |
| AU015566 | |
| mKIAA0491 | |
| SH3-domain GRB2-like B1 (endophilin) | |
| Kiaa0491 | |
| OTTHUMP00000011912 | |
| SH3-containing protein SH3GLB I | |
| SH3-containing protein SH3GLB1, CGI-61 protein, endophilin B1 | |
| sh3-domain grb2-like b1 | |
| SH3-domain GRB2-like endophilin B1 | |
| SH3-domain, GRB2-like, endophilin B | |
| SH3GLB I | |
| SH3GLB1 | |
| Bif I | |
| Bax-interactive factor 1 | |
| Bax-interacting factor I | |
| Bax-interactive factor I | |
| endophilin B | |
| endophilin B1 | |
| endophilin B1b |
| Mouse chromosome position | 3 |
|---|
| OMIM ID | 609287 |
|---|
| Rat chromosome position | 2q44 |
|---|
| Hugo ID | 10833 |
|---|
| Human chromosome position | 1p22 |
|---|
| Swiss-Prot Accession | Q9Y371 |
|---|---|
| Q9JK48 | |
| Q3TYR7 | |
| Q6AYE2 | |
| Q6A059 | |
| Q8CDS9 | |
| Q8VI52 | |
| Q9CT31 | |
| B4E182 | |
| Q5H8U5 | |
| Q9H3Z0 | |
| Q9NR47 | |
| Q9NYA9 |
| Unigene ID | Hs.136309 |
|---|---|
| Mm.271775 | |
| Mm.440295 | |
| Rn.203013 |
| KEGG ID | hsa:51100 |
|---|---|
| mmu:54673 | |
| rno:292156 |
| Swiss-Prot ID | SHLB1_MOUSE |
|---|---|
| SHLB1_RAT | |
| SHLB1_HUMAN |
| Ensembl ID | ENSG00000097033 |
|---|---|
| ENSP00000473267 | |
| ENST00000370558 | |
| ENSRNOG00000012957 | |
| ENSRNOP00000017771 | |
| ENSRNOT00000017770 |
| Homologene ID | 9337 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1859730 |
|---|
| RGD ID | 1304859 |
|---|
| MedScan ID | 51100 |
|---|