| URN | urn:agi-llid:51024 |
|---|---|
| Total Entities | 0 |
| Connectivity | 71 |
| Name | Fis1 |
| Description | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) |
| Notes | The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008] |
| GO Molecular Function | receptor binding |
|---|
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| integral component of mitochondrial outer membrane | |
| integral component of peroxisomal membrane | |
| mitochondrial outer membrane | |
| protein complex | |
| endoplasmic reticulum | |
| mitochondrion | |
| peroxisome |
| GO Biological Process | mitochondrion morphogenesis |
|---|---|
| mitochondrial fusion | |
| calcium-mediated signaling using intracellular calcium source | |
| positive regulation of intrinsic apoptotic signaling pathway | |
| release of cytochrome c from mitochondria | |
| positive regulation of cytosolic calcium ion concentration | |
| negative regulation of endoplasmic reticulum calcium ion concentration | |
| positive regulation of mitochondrial calcium ion concentration | |
| apoptotic process | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| mitochondrial fragmentation involved in apoptotic process | |
| positive regulation of protein targeting to membrane | |
| protein targeting to mitochondrion | |
| positive regulation of mitochondrial fission | |
| regulation of mitochondrion organization | |
| mitochondrion degradation | |
| mitochondrial fission | |
| peroxisome fission | |
| protein homooligomerization |
| Pathway | Mitochondrial Fusion and Fission |
|---|---|
| Overview of Mitochondrial Dysfunction in Alzheimer's Disease | |
| Mitochondria Enlargement and Apoptosis in Alzheimer's Disease | |
| mitochondria dynamics pathway |
| Group | Mitochondrion fission |
|---|---|
| mitochondrion morphogenesis | |
| mitochondrial fusion | |
| calcium-mediated signaling using intracellular calcium source | |
| positive regulation of intrinsic apoptotic signaling pathway | |
| release of cytochrome c from mitochondria | |
| positive regulation of cytosolic calcium ion concentration | |
| negative regulation of endoplasmic reticulum calcium ion concentration | |
| positive regulation of mitochondrial calcium ion concentration | |
| apoptotic process | |
| positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | |
| mitochondrial fragmentation involved in apoptotic process | |
| positive regulation of protein targeting to membrane | |
| protein targeting to mitochondrion | |
| positive regulation of mitochondrial fission | |
| regulation of mitochondrion organization | |
| mitochondrion degradation | |
| mitochondrial fission | |
| peroxisome fission | |
| protein homooligomerization | |
| receptor binding | |
| membrane | |
| integral component of membrane | |
| integral component of mitochondrial outer membrane | |
| integral component of peroxisomal membrane | |
| mitochondrial outer membrane | |
| protein complex | |
| endoplasmic reticulum | |
| mitochondrion | |
| peroxisome |
| LocusLink ID | 51024 |
|---|---|
| 66437 | |
| 288584 |
| Cell Localization | Mitochondria |
|---|---|
| Mitochondrion outer membrane | |
| Peroxisome membrane |
| GO ID | 0005102 |
|---|---|
| 0035584 | |
| 0000266 | |
| 0043653 | |
| 0008053 | |
| 0000422 | |
| 0070584 | |
| 0032471 | |
| 0016559 | |
| 0043280 | |
| 0007204 | |
| 2001244 | |
| 0051561 | |
| 0090141 | |
| 0090314 | |
| 0051260 | |
| 0006626 | |
| 0010821 | |
| 0001836 | |
| 0031307 | |
| 0005779 | |
| 0005739 | |
| 0005777 | |
| 0043234 | |
| 0006915 | |
| 0005783 | |
| 0016021 | |
| 0016020 | |
| 0005741 |
| Alias | TTC11 |
|---|---|
| CGI-135 | |
| mitochondrial fission 1 protein | |
| hFis1 | |
| FIS1 homolog | |
| H_NH0132A01.6 | |
| TPR repeat protein 11 | |
| tetratricopeptide repeat domain 11 | |
| tetratricopeptide repeat protein 11 | |
| 2010003O14Rik | |
| rFis1 | |
| tetratricopeptide repeat domain XI | |
| OTTMUSP00000027341 | |
| OTTMUSP00000027340 | |
| fission 1 (mitochondrial outer membrane) homolog (yeast) | |
| fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | |
| fission 1 (mitochondrial outer membrane) homolog | |
| 2010003O14 | |
| human Fis1 |
| Mouse chromosome position | 5 |
|---|
| OMIM ID | 609003 |
|---|
| Rat chromosome position | 12q12 |
|---|
| Hugo ID | 21689 |
|---|
| Human chromosome position | 7q22.1 |
|---|
| Swiss-Prot Accession | Q9Y3D6 |
|---|---|
| G3X9U9 | |
| Q9CQ92 | |
| P84817 | |
| B2RZ80 | |
| D4A5K3 | |
| Q9BTP3 |
| Unigene ID | Hs.423968 |
|---|---|
| Mm.25849 | |
| Rn.1298 |
| KEGG ID | hsa:51024 |
|---|---|
| mmu:66437 | |
| rno:288584 |
| Swiss-Prot ID | FIS1_MOUSE |
|---|---|
| FIS1_RAT | |
| FIS1_HUMAN |
| Ensembl ID | ENSG00000214253 |
|---|---|
| ENSP00000223136 | |
| ENST00000223136 | |
| ENSMUSG00000019054 | |
| ENSMUSP00000106723 | |
| ENSMUST00000111094 | |
| ENSMUSP00000019198 | |
| ENSMUST00000019198 | |
| ENSRNOG00000001420 | |
| ENSRNOP00000001924 | |
| ENSRNOT00000001924 |
| Homologene ID | 41099 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1913687 |
|---|
| RGD ID | 1306668 |
|---|
| MedScan ID | 51024 |
|---|