| URN | urn:agi-llid:10059 |
|---|---|
| Total Entities | 0 |
| Connectivity | 456 |
| Name | Dnm1l |
| Description | dynamin 1-like |
| Notes | This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013] |
| GO Molecular Function | GTPase activity |
|---|---|
| hydrolase activity | |
| ubiquitin protein ligase binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| GTP binding |
| GO Cellular Component | membrane |
|---|---|
| synapse | |
| cell junction | |
| coated pit | |
| mitochondrial outer membrane | |
| synaptic vesicle membrane | |
| microtubule | |
| protein complex | |
| cytoplasm | |
| Golgi apparatus | |
| cytosol | |
| perinuclear region of cytoplasm | |
| cytoplasmic vesicle | |
| mitochondrion | |
| peroxisome | |
| intracellular membrane-bounded organelle |
| GO Biological Process | GTP catabolic process |
|---|---|
| mitochondrion morphogenesis | |
| positive regulation of intrinsic apoptotic signaling pathway | |
| release of cytochrome c from mitochondria | |
| positive regulation of release of cytochrome c from mitochondria | |
| positive regulation of protein secretion | |
| cellular component disassembly involved in execution phase of apoptosis | |
| programmed cell death | |
| apoptotic process | |
| positive regulation of apoptotic process | |
| mitochondrial fragmentation involved in apoptotic process | |
| necroptotic process | |
| membrane fission involved in mitochondrial fission | |
| dynamin polymerization involved in mitochondrial fission | |
| positive regulation of mitochondrial fission | |
| regulation of protein oligomerization | |
| regulation of mitochondrion organization | |
| regulation of peroxisome organization | |
| endocytosis | |
| mitochondrial fission | |
| peroxisome fission | |
| protein homotetramerization | |
| membrane fusion |
| Pathway | Mitochondrial Fusion and Fission |
|---|---|
| Peroxisome Protein Import and Peroxisome Division | |
| Overview of Mitochondrial Dysfunction in Alzheimer's Disease | |
| Mitochondria Enlargement and Apoptosis in Alzheimer's Disease | |
| mitochondria dynamics pathway |
| Group | Mitochondrion fission |
|---|---|
| Peroxisome division | |
| GTP catabolic process | |
| GTPase activity | |
| mitochondrion morphogenesis | |
| positive regulation of intrinsic apoptotic signaling pathway | |
| release of cytochrome c from mitochondria | |
| positive regulation of release of cytochrome c from mitochondria | |
| positive regulation of protein secretion | |
| cellular component disassembly involved in execution phase of apoptosis | |
| programmed cell death | |
| apoptotic process | |
| positive regulation of apoptotic process | |
| mitochondrial fragmentation involved in apoptotic process | |
| necroptotic process | |
| membrane fission involved in mitochondrial fission | |
| dynamin polymerization involved in mitochondrial fission | |
| positive regulation of mitochondrial fission | |
| regulation of protein oligomerization | |
| regulation of mitochondrion organization | |
| regulation of peroxisome organization | |
| hydrolase activity | |
| endocytosis | |
| mitochondrial fission | |
| peroxisome fission | |
| protein homotetramerization | |
| membrane fusion | |
| ubiquitin protein ligase binding | |
| protein homodimerization activity | |
| nucleotide binding | |
| GTP binding | |
| membrane | |
| synapse | |
| cell junction | |
| coated pit | |
| mitochondrial outer membrane | |
| synaptic vesicle membrane | |
| microtubule | |
| protein complex | |
| cytoplasm | |
| Golgi apparatus | |
| cytosol | |
| perinuclear region of cytoplasm | |
| cytoplasmic vesicle | |
| mitochondrion | |
| peroxisome | |
| intracellular membrane-bounded organelle | |
| Secreted proteins |
| LocusLink ID | 10059 |
|---|---|
| 74006 | |
| 114114 |
| Cell Localization | Mitochondria |
|---|---|
| Peroxisome | |
| Cytoplasm | |
| Cytosol | |
| Golgi apparatus | |
| Endomembrane system | |
| Mitochondrion outer membrane | |
| Membrane | |
| Clathrin-coated pit | |
| Cytoplasmic vesicle | |
| Secretory vesicle | |
| Synaptic vesicle membrane |
| GO ID | 0005525 |
|---|---|
| 0003924 | |
| 0042803 | |
| 0031625 | |
| 0006184 | |
| 0006915 | |
| 0006921 | |
| 0003374 | |
| 0006897 | |
| 0090149 | |
| 0061025 | |
| 0000266 | |
| 0043653 | |
| 0070584 | |
| 0070266 | |
| 0016559 | |
| 0043065 | |
| 2001244 | |
| 0090141 | |
| 0050714 | |
| 0090200 | |
| 0051289 | |
| 0010821 | |
| 1900063 | |
| 0032459 | |
| 0001836 | |
| 0005794 | |
| 0030054 | |
| 0005905 | |
| 0005737 | |
| 0005829 | |
| 0005874 | |
| 0005741 | |
| 0005739 | |
| 0048471 | |
| 0005777 | |
| 0043234 | |
| 0030672 | |
| 0016787 | |
| 0000166 | |
| 0012501 | |
| 0031410 | |
| 0043231 | |
| 0016020 | |
| 0045202 |
| Alias | DLP1 |
|---|---|
| DRP1 | |
| DVLP | |
| EMPF | |
| DYMPLE | |
| HDYNIV | |
| dynamin-1-like protein | |
| dynamin-like protein 4 | |
| dynamin-like protein IV | |
| Dnm1p/Vps1p-like protein | |
| dynamin-related protein 1 | |
| dynamin family member proline-rich carboxyl-terminal domain less | |
| Dnmlp1 | |
| python | |
| AI450666 | |
| 6330417M19Rik | |
| Dnml1 | |
| C-terminal region | |
| N-terminal region | |
| dynamin-like protein 1 | |
| Dnmlp I | |
| DYNIV-11 | |
| FLJ41912 | |
| LOC224013 | |
| MGC90593 | |
| VPS I | |
| VPS1 | |
| dynamin-like protein I | |
| DNM1L | |
| 6330417M19 | |
| Dnml I | |
| dynamin 1-like | |
| Dynamin-like protein |
| Mouse chromosome position | 16 |
|---|
| OMIM ID | 603850 |
|---|---|
| 614388 |
| Rat chromosome position | 11q23 |
|---|
| Hugo ID | 2973 |
|---|
| Human chromosome position | 12p11.21 |
|---|
| Swiss-Prot Accession | B4DYR6 |
|---|---|
| O00429 | |
| J3KPI2 | |
| Q59GN9 | |
| B4DGC9 | |
| G8JLD5 | |
| Q8K1M6 | |
| E9PUD2 | |
| O35303 | |
| Q8BNQ5 | |
| Q8BQ64 | |
| Q8CGD0 | |
| Q8K1A1 | |
| O35318 | |
| O35319 | |
| O35320 | |
| O35321 | |
| O35322 | |
| O35323 | |
| Q5U2W1 | |
| Q792T7 | |
| Q9R234 | |
| Q9R277 | |
| A8K4X9 | |
| B4DSU8 | |
| O14541 | |
| O60709 | |
| Q7L6B3 | |
| Q8TBT7 | |
| Q9BWM1 | |
| Q9Y5J2 |
| PIR ID | JC5695 |
|---|
| Unigene ID | Hs.556296 |
|---|---|
| Mm.218820 | |
| Rn.216851 |
| KEGG ID | hsa:10059 |
|---|---|
| mmu:74006 | |
| rno:114114 |
| Swiss-Prot ID | DNM1L_MOUSE |
|---|---|
| DNM1L_RAT | |
| DNM1L_HUMAN |
| EC Number | 3.6.5.5 |
|---|
| Ensembl ID | ENSG00000087470 |
|---|---|
| ENSP00000370388 | |
| ENST00000381000 | |
| ENSP00000415131 | |
| ENST00000452533 | |
| ENSMUSG00000022789 | |
| ENSMUSP00000023477 | |
| ENSMUST00000023477 | |
| ENSMUSP00000111415 | |
| ENSMUST00000115749 | |
| ENSMUSP00000093945 | |
| ENSMUST00000096229 |
| Homologene ID | 6384 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1921256 |
|---|
| RGD ID | 620416 |
|---|
| MedScan ID | 10059 |
|---|