| URN | urn:agi-llid:56947 |
|---|---|
| Total Entities | 0 |
| Connectivity | 35 |
| Name | Mff |
| Description | mitochondrial fission factor |
| Notes | This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] |
| GO Molecular Function | protein homodimerization activity |
|---|
| GO Cellular Component | membrane |
|---|---|
| synapse | |
| cell junction | |
| integral component of membrane | |
| integral component of mitochondrial membrane | |
| mitochondrial outer membrane | |
| cytoplasm | |
| cytoplasmic vesicle | |
| mitochondrion | |
| peroxisome | |
| synaptic vesicle |
| GO Biological Process | mitochondrion morphogenesis |
|---|---|
| mitochondrial fusion | |
| release of cytochrome c from mitochondria | |
| positive regulation of release of cytochrome c from mitochondria | |
| mitochondrial fragmentation involved in apoptotic process | |
| positive regulation of protein targeting to membrane | |
| protein targeting to mitochondrion | |
| positive regulation of mitochondrial fission | |
| regulation of mitochondrion organization | |
| regulation of peroxisome organization | |
| mitochondrial fission | |
| peroxisome fission | |
| protein homooligomerization |
| Pathway | mitochondria dynamics pathway |
|---|
| Group | mitochondrion morphogenesis |
|---|---|
| mitochondrial fusion | |
| release of cytochrome c from mitochondria | |
| positive regulation of release of cytochrome c from mitochondria | |
| mitochondrial fragmentation involved in apoptotic process | |
| positive regulation of protein targeting to membrane | |
| protein targeting to mitochondrion | |
| positive regulation of mitochondrial fission | |
| regulation of mitochondrion organization | |
| regulation of peroxisome organization | |
| mitochondrial fission | |
| peroxisome fission | |
| protein homooligomerization | |
| protein homodimerization activity | |
| membrane | |
| synapse | |
| cell junction | |
| integral component of membrane | |
| integral component of mitochondrial membrane | |
| mitochondrial outer membrane | |
| cytoplasm | |
| cytoplasmic vesicle | |
| mitochondrion | |
| peroxisome | |
| synaptic vesicle | |
| Secreted proteins |
| LocusLink ID | 56947 |
|---|---|
| 75734 |
| Cell Localization | Mitochondrion outer membrane |
|---|---|
| Peroxisome | |
| Cytoplasmic vesicle | |
| Secretory vesicle | |
| Synaptic vesicle |
| GO ID | 0042803 |
|---|---|
| 0000266 | |
| 0043653 | |
| 0008053 | |
| 0070584 | |
| 0016559 | |
| 0090141 | |
| 0090314 | |
| 0090200 | |
| 0051260 | |
| 0006626 | |
| 0010821 | |
| 1900063 | |
| 0001836 | |
| 0030054 | |
| 0005737 | |
| 0032592 | |
| 0005741 | |
| 0005777 | |
| 0008021 | |
| 0031410 | |
| 0016021 | |
| 0016020 | |
| 0005739 | |
| 0045202 |
| Alias | GL004 |
|---|---|
| C2orf33 | |
| AD030 | |
| mitochondrial fission factor | |
| AI314724 | |
| 5230400G24Rik | |
| OTTHUMP00000164235 | |
| OTTHUMP00000203989 | |
| MGC110913 | |
| 5230400G24 | |
| DKFZp666J168 |
| Mouse chromosome position | 1 |
|---|
| OMIM ID | 614785 |
|---|
| Hugo ID | 24858 |
|---|
| Human chromosome position | 2q36.3 |
|---|
| Swiss-Prot Accession | Q9GZY8 |
|---|---|
| Q6PCP5 | |
| Q3UT87 | |
| Q91VG0 | |
| Q9D3P5 | |
| Q567U1 | |
| Q658R6 | |
| Q9BVZ1 | |
| Q9H690 | |
| Q9NRG8 |
| Unigene ID | Hs.471528 |
|---|---|
| Mm.396863 |
| KEGG ID | hsa:56947 |
|---|---|
| mmu:75734 |
| Swiss-Prot ID | MFF_MOUSE |
|---|---|
| MFF_HUMAN |
| Ensembl ID | ENSG00000168958 |
|---|---|
| ENSP00000302037 | |
| ENST00000353339 | |
| ENSP00000304898 | |
| ENST00000304593 | |
| ENSP00000338412 | |
| ENST00000337110 | |
| ENSP00000304134 | |
| ENST00000349901 | |
| ENSP00000386964 | |
| ENST00000409565 | |
| ENSP00000375912 | |
| ENST00000392059 | |
| ENSMUSG00000026150 | |
| ENSMUSP00000077446 | |
| ENSMUST00000078332 | |
| ENSMUSP00000072784 | |
| ENSMUST00000073025 | |
| ENSMUSP00000125230 | |
| ENSMUST00000160786 | |
| ENSMUSP00000124200 | |
| ENSMUST00000160972 |
| Homologene ID | 87000 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| MGI ID | 1922984 |
|---|
| RGD ID | 1310230 |
|---|
| MedScan ID | 56947 |
|---|