Elsevier Inc. Trak/Milton ATP cardiolipin Opa1i Miro kinesin motor dynein motor Mff Dnm1l cardiolipin ---> phosphatidic acid Pld6 cardiolipin --+> Opa1i cardiolipin metabolic pathway Mfn1 ---- Mfn2 Stoml2 Miro ---- Trak/Milton Snph dynactin complex ---- dynein motor ATP hydrolysis --+> anterograde movement ATP hydrolysis --+> retrograde movement anterograde movement ATP hydrolysis retrograde movement kinesin motor ---> ATP hydrolysis dynein motor ---> ATP hydrolysis phosphatidic acid phosphatidic acid --+> mitochondria fusion pathway Dnm1l ---- Mff Dnm1l ---- Mief2 Dnm1l ---- Mief1 Mief2 Fis1 Gdap1 Mtfp1 Mief1 Opa1 Phb2 Sh3glb1 mitochondrial autophagy pathway ---| mitochondria fusion pathway mitochondrial autophagy pathway ---| mitochondria transport pathway mitochondria fusion pathway mitochondria fission pathway ATP ---- dynein motor ATP ---- kinesin motor kinesin motor ---- Trak/Milton dynein motor ---- Trak/Milton mitochondrial autophagy pathway mitochondria transport pathway other adaptors dynactin complex Mfn2 Mfn1