| URN | urn:agi-llid:7332 |
|---|---|
| Total Entities | 0 |
| Connectivity | 115 |
| Name | Ube2l3 |
| Description | ubiquitin-conjugating enzyme E2L 3 |
| Notes | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009] |
| GO Molecular Function | transcription coactivator activity |
|---|---|
| ubiquitin-protein ligase activity | |
| enzyme binding | |
| ubiquitin protein ligase binding | |
| ATP binding |
| GO Cellular Component | ubiquitin ligase complex |
|---|---|
| cytoplasm | |
| nucleus |
| GO Biological Process | cell proliferation |
|---|---|
| cellular response to steroid hormone stimulus | |
| cellular response to glucocorticoid stimulus | |
| regulation of transcription, DNA-templated | |
| transcription, DNA-templated | |
| cellular protein modification process | |
| protein ubiquitination | |
| protein polyubiquitination | |
| protein K11-linked ubiquitination | |
| ubiquitin-dependent protein catabolic process |
| Pathway | Dendritic Cell Function in Crohn's Disease |
|---|---|
| Crohn's Disease Overview | |
| TLR4 Signaling in Leukocytes | |
| mitochondrial autophagy pathway | |
| altered mitochondrial autophagy pathway |
| Group | Ubiquitin-dependent protein degradation |
|---|---|
| cell proliferation | |
| cellular response to steroid hormone stimulus | |
| cellular response to glucocorticoid stimulus | |
| regulation of transcription, DNA-templated | |
| transcription coactivator activity | |
| ubiquitin-protein ligase activity | |
| transcription, DNA-templated | |
| cellular protein modification process | |
| protein ubiquitination | |
| protein polyubiquitination | |
| protein K11-linked ubiquitination | |
| ubiquitin-dependent protein catabolic process | |
| enzyme binding | |
| ubiquitin protein ligase binding | |
| ATP binding | |
| ubiquitin ligase complex | |
| cytoplasm | |
| nucleus |
| LocusLink ID | 7332 |
|---|---|
| 22195 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| GO ID | 0005524 |
|---|---|
| 0019899 | |
| 0003713 | |
| 0031625 | |
| 0004842 | |
| 0008283 | |
| 0006464 | |
| 0071385 | |
| 0071383 | |
| 0070979 | |
| 0000209 | |
| 0016567 | |
| 0006355 | |
| 0006351 | |
| 0006511 | |
| 0005737 | |
| 0005634 | |
| 0000151 |
| Alias | E2-F1 |
|---|---|
| L-UBC | |
| UBCH7 | |
| UbcM4 | |
| ubiquitin-conjugating enzyme E2 L3 | |
| ubiquitin-protein ligase L3 | |
| ubiquitin carrier protein L3 | |
| ubiquitin-conjugating enzyme E2-F1 | |
| ubiquitin-conjugating enzyme UBCH7 | |
| Ubce7 | |
| C79827 | |
| ubiquitin-conjugating enzyme 7 | |
| UBE2L3 | |
| ubiquitin-conjugating enzyme E2L III | |
| ubiquitin-conjugating enzyme E2L 3 | |
| Ubiquitin-conjugating enzyme E2-18 kDa UBCH7 | |
| UBC7_HUMAN | |
| OTTMUSP00000029960 | |
| OTTMUSP00000029959 | |
| MGC118100 | |
| LOC240264 |
| Mouse chromosome position | 16 10.63 cM |
|---|
| OMIM ID | 603721 |
|---|
| Hugo ID | 12488 |
|---|
| Human chromosome position | 22q11.21 |
|---|
| Swiss-Prot Accession | P68036 |
|---|---|
| P68037 | |
| Q561N4 | |
| B2R4A7 | |
| B4DDG1 | |
| B4DSZ4 | |
| E7EWS7 | |
| P51966 | |
| P70653 | |
| Q9HAV1 |
| Unigene ID | Hs.108104 |
|---|---|
| Mm.3074 |
| KEGG ID | hsa:7332 |
|---|---|
| mmu:22195 |
| Swiss-Prot ID | UB2L3_HUMAN |
|---|
| EC Number | 6.3.2.19 |
|---|
| Ensembl ID | ENSG00000185651 |
|---|---|
| ENSP00000344259 | |
| ENST00000342192 | |
| ENSMUSG00000038965 | |
| ENSMUSP00000087658 | |
| ENSMUST00000090192 |
| Homologene ID | 43226 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus |
| MGI ID | 109240 |
|---|
| RGD ID | 1308361 |
|---|
| MedScan ID | 7332 |
|---|