| URN | urn:agi-llid:55486 |
|---|---|
| Total Entities | 0 |
| Connectivity | 85 |
| Name | Parl |
| Description | presenilin associated, rhomboid-like |
| Notes | This gene encodes a mitochondrial integral membrane protein. Following proteolytic processing of this protein, a small peptide (P-beta) is formed and translocated to the nucleus. This gene may be involved in signal transduction via regulated intramembrane proteolysis of membrane-tethered precursor proteins. Variation in this gene has been associated with increased risk for type 2 diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | hydrolase activity |
|---|---|
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| mitochondrial inner membrane | |
| mitochondrion | |
| nucleus |
| GO Biological Process | negative regulation of intrinsic apoptotic signaling pathway |
|---|---|
| negative regulation of release of cytochrome c from mitochondria | |
| proteolysis |
| Pathway | mitochondrial autophagy pathway |
|---|---|
| altered mitochondrial autophagy pathway |
| Group | negative regulation of intrinsic apoptotic signaling pathway |
|---|---|
| negative regulation of release of cytochrome c from mitochondria | |
| hydrolase activity | |
| peptidase activity | |
| serine-type peptidase activity | |
| serine-type endopeptidase activity | |
| proteolysis | |
| membrane | |
| integral component of membrane | |
| mitochondrial inner membrane | |
| mitochondrion | |
| nucleus |
| LocusLink ID | 55486 |
|---|---|
| 381038 | |
| 287979 |
| Cell Localization | Mitochondrion inner membrane |
|---|---|
| Nucleus |
| GO ID | 0004252 |
|---|---|
| 2001243 | |
| 0090201 | |
| 0006508 | |
| 0016021 | |
| 0005743 | |
| 0005739 | |
| 0005634 | |
| 0016787 | |
| 0008233 | |
| 0008236 | |
| 0016020 |
| Alias | PSARL |
|---|---|
| PSARL1 | |
| RHBDS1 | |
| PRO2207 | |
| PSENIP2 | |
| presenilins-associated rhomboid-like protein, mitochondrial | |
| rhomboid 7 homolog 1 | |
| mitochondrial intramembrane cleaving protease PARL | |
| mitochondrial intramembrane-cleaving protease PARL | |
| D16Ertd607e | |
| presenilins associated rhomboid-like protein | |
| rhomboid-like | |
| presenilin associated, rhomboid-like | |
| DNA segment, Chr 16, ERATO Doi 607, expressed | |
| PARL | |
| LOC208159 | |
| MGC125008 | |
| mitochondrial intramembrane-cleaving proteinase PARL | |
| OTTHUMP00000210937 | |
| OTTHUMP00000210938 | |
| OTTMUSP00000030672 |
| Mouse chromosome position | 16 12.4 cM |
|---|
| OMIM ID | 607858 |
|---|
| Rat chromosome position | 11q23 |
|---|
| Hugo ID | 18253 |
|---|
| Human chromosome position | 3q27.1 |
|---|
| Swiss-Prot Accession | Q9H300 |
|---|---|
| Q5XJY4 | |
| B0BMU4 | |
| Q3B8P0 | |
| Q5I0L2 | |
| Q3U9T5 | |
| Q641T5 | |
| Q96CQ4 | |
| Q9BTJ6 | |
| Q9P1E3 |
| Unigene ID | Hs.478469 |
|---|---|
| Mm.371737 | |
| Rn.7053 |
| KEGG ID | hsa:55486 |
|---|---|
| mmu:381038 | |
| rno:287979 |
| Swiss-Prot ID | PARL_RAT |
|---|---|
| PARL_MOUSE | |
| PARL_HUMAN |
| EC Number | 3.4.21.105 |
|---|
| Ensembl ID | ENSG00000175193 |
|---|---|
| ENSP00000310676 | |
| ENST00000311101 | |
| ENSP00000325421 | |
| ENST00000317096 | |
| ENSMUSG00000033918 | |
| ENSMUSP00000045361 | |
| ENSMUST00000048642 | |
| ENSRNOG00000023271 | |
| ENSRNOP00000029124 | |
| ENSRNOT00000030837 |
| Homologene ID | 10239 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1277152 |
|---|
| RGD ID | 1306191 |
|---|
| MedScan ID | 55486 |
|---|