| URN | urn:agi-llid:65018 |
|---|---|
| Total Entities | 0 |
| Connectivity | 518 |
| Name | Pink1 |
| Description | PTEN induced putative kinase 1 |
| Notes | This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | transferase activity |
|---|---|
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| calcium-dependent protein kinase activity | |
| protein serine-threonine kinase activity | |
| ubiquitin protein ligase binding | |
| C3HC4-type RING finger domain binding | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| magnesium ion binding |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| mitochondrial outer membrane | |
| mitochondrial inner membrane | |
| cytoplasm | |
| cytosol | |
| mitochondrion |
| GO Biological Process | cell death |
|---|---|
| intracellular signal transduction | |
| positive regulation of I-kappaB kinase-NF-kappaB signaling | |
| positive regulation of release of cytochrome c from mitochondria | |
| positive regulation of synaptic transmission, dopaminergic | |
| positive regulation of catecholamine secretion | |
| positive regulation of dopamine secretion | |
| regulation of neuron apoptotic process | |
| negative regulation of neuron apoptotic process | |
| response to stress | |
| cellular response to toxic substance | |
| regulation of protein complex assembly | |
| regulation of protein ubiquitination | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| phosphorylation | |
| autophagy | |
| mitochondrion degradation |
| Pathway | Mitochondrial Fusion and Fission |
|---|---|
| Young Onset PARK2, PINK1, and UCHL1 Induced Parkinson's Disease | |
| Proteins Involved in Pathogenesis of Parkinson's Disease | |
| mitochondrial autophagy pathway | |
| altered mitochondrial autophagy pathway | |
| Parkinson disease pathway |
| Group | Protein kinases |
|---|---|
| cell death | |
| intracellular signal transduction | |
| positive regulation of I-kappaB kinase-NF-kappaB signaling | |
| positive regulation of release of cytochrome c from mitochondria | |
| positive regulation of synaptic transmission, dopaminergic | |
| positive regulation of catecholamine secretion | |
| positive regulation of dopamine secretion | |
| regulation of neuron apoptotic process | |
| negative regulation of neuron apoptotic process | |
| response to stress | |
| cellular response to toxic substance | |
| regulation of protein complex assembly | |
| regulation of protein ubiquitination | |
| transferase activity | |
| transferase activity, transferring phosphorus-containing groups | |
| kinase activity | |
| protein kinase activity | |
| calcium-dependent protein kinase activity | |
| protein serine-threonine kinase activity | |
| protein phosphorylation | |
| peptidyl-serine phosphorylation | |
| phosphorylation | |
| autophagy | |
| mitochondrion degradation | |
| ubiquitin protein ligase binding | |
| C3HC4-type RING finger domain binding | |
| nucleotide binding | |
| ATP binding | |
| metal ion binding | |
| magnesium ion binding | |
| membrane | |
| integral component of membrane | |
| mitochondrial outer membrane | |
| mitochondrial inner membrane | |
| cytoplasm | |
| cytosol | |
| mitochondrion | |
| Genes with Mutations Associated with Parkinson's Disease | |
| Secreted proteins |
| LocusLink ID | 65018 |
|---|---|
| 68943 | |
| 298575 |
| Cell Localization | Cytoplasm |
|---|---|
| Mitochondrion outer membrane | |
| Cytosol |
| GO ID | 0005524 |
|---|---|
| 0055131 | |
| 0010857 | |
| 0016301 | |
| 0000287 | |
| 0004674 | |
| 0031625 | |
| 0008219 | |
| 0097237 | |
| 0035556 | |
| 0000422 | |
| 0043524 | |
| 0018105 | |
| 0043123 | |
| 0033603 | |
| 0090200 | |
| 0032226 | |
| 0006468 | |
| 0043254 | |
| 0031396 | |
| 0006950 | |
| 0005829 | |
| 0016021 | |
| 0005741 | |
| 0005739 | |
| 0046872 | |
| 0000166 | |
| 0004672 | |
| 0016740 | |
| 0016772 | |
| 0006914 | |
| 0016310 | |
| 0033605 | |
| 0043523 | |
| 0005737 | |
| 0016020 | |
| 0005743 |
| Alias | BRPK |
|---|---|
| PARK6 | |
| serine/threonine-protein kinase PINK1, mitochondrial | |
| protein kinase BRPK | |
| PTEN-induced putative kinase protein 1 | |
| AU042772 | |
| AW557854 | |
| mFLJ00387 | |
| 1190006F07Rik | |
| Parkinson disease 6 | |
| phosphatase and tensin homologue-induced kinase 1 | |
| PINK1 | |
| PTEN induced kinase 1 | |
| PTEN induced kinase I | |
| PTEN-induced kinase | |
| serine/threonine-protein kinase PINK1 | |
| Parkinson disease VI | |
| Parkinson disease (autosomal recessive) VI | |
| PTEN-induced putative kinase-1 | |
| Parkinson disease (autosomal recessive) 6 | |
| FLJ27236 | |
| MGC189438 | |
| OTTHUMP00000002881 | |
| PINK I | |
| OTTMUSP00000010580 | |
| 1190006F07 |
| Mouse chromosome position | 4 |
|---|
| OMIM ID | 608309 |
|---|---|
| 605909 |
| Rat chromosome position | 5q36 |
|---|
| Hugo ID | 14581 |
|---|
| Human chromosome position | 1p36 |
|---|
| Swiss-Prot Accession | Q9BXM7 |
|---|---|
| Q99MQ3 | |
| D3Z9M9 | |
| Q8N6T9 | |
| Q8NBU3 | |
| Q96DE4 | |
| A2AM77 | |
| Q7TMZ3 | |
| Q811I8 | |
| Q91XU5 |
| Unigene ID | Hs.389171 |
|---|---|
| Mm.18539 | |
| Rn.219286 | |
| Rn.219317 |
| KEGG ID | hsa:65018 |
|---|---|
| mmu:68943 | |
| rno:298575 |
| Swiss-Prot ID | PINK1_HUMAN |
|---|---|
| PINK1_MOUSE |
| EC Number | 2.7.11.1 |
|---|
| Ensembl ID | ENSG00000158828 |
|---|---|
| ENSP00000364204 | |
| ENST00000321556 | |
| ENSMUSG00000028756 | |
| ENSMUSP00000030536 | |
| ENSMUST00000030536 |
| Homologene ID | 32672 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1916193 |
|---|
| RGD ID | 1305769 |
|---|
| MedScan ID | 65018 |
|---|