Elsevier Inc. Pink1 ---> Parkinson Disease (PD) Park2 ---> Parkinson Disease (PD) Pink1 ---> Parkinson disease pathway Park2 ---> Parkinson disease pathway Parkinson Disease (PD) Park2 Parkinson disease pathway Pink1 Atxn3 translocated cardiolipin other autophagy/mitophagy components Gabarap Map1lc3b Map1lc3a canonical K48, K63 and noncanonical K6, K11 linkages Fundc1 Sqstm1 deubiquitinases Optn Pink1_IMM Map1lc3b ---- translocated cardiolipin casein kinase 2 autophagophore recruitment Pgam5 Bnip3l ---- Map1lc3b Bnip3l ---- Gabarap Src ---| Fundc1 Src ---> Fundc1 Pgam5 ---> Fundc1 Pgam5 --+> Fundc1 Fundc1 ---- Map1lc3b Bnip3 ---- Map1lc3b Fundc1 ---- Map1lc3a Bnip3l ---- Map1lc3a Map1lc3b ---- Optn Map1lc3b ---- Sqstm1 Map1lc3a ---- Optn Map1lc3a ---- Sqstm1 casein kinase 2 ---| Fundc1 casein kinase 2 ---> Fundc1 Src Pink1 ---> Pink1_IMM Parl ---| Pink1_IMM Parl Parl ---> Pink1_IMM Tomm7 Tomm7 --+> Pink1 deubiquitinases ---> Parkin substrates Bnip3 ---- Map1lc3a Atxn3 ---| Park2 Ube2l3 Atxn3 ---- Ube2l3 mitochondria transport pathway mitochondria fusion pathway cardiolipin metabolic pathway Bnip3 hypoxia inducible factor pathway Bnip3l hypoxia inducible factor pathway ---> Bnip3l hypoxia inducible factor pathway ---> Bnip3 Parkin substrates