Protein Sqstm1

URN	urn:agi-llid:8878
Total Entities	0
Connectivity	418
Name	Sqstm1
Description	sequestosome 1
Notes	This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq, Mar 2009]

GO Molecular Function	transcription cofactor activity
	protein serine-threonine kinase activity
	receptor tyrosine kinase binding
	protein kinase binding
	protein kinase C binding
	SH2 domain binding
	ubiquitin binding
	K63-linked polyubiquitin binding
	protein homodimerization activity
	metal ion binding
	zinc ion binding

GO Cellular Component	nucleoplasm
	cytoplasmic mRNA processing body
	cytoplasm
	pre-autophagosomal structure
	cytosol
	endoplasmic reticulum
	endosome
	cytoplasmic vesicle
	autophagic vacuole
	lysosome
	late endosome
	aggresome
	nucleus

GO Biological Process	immune system process
	macroautophagy
	cell differentiation
	intracellular signal transduction
	apoptotic signaling pathway
	regulation of I-kappaB kinase-NF-kappaB signaling
	regulation of Ras protein signal transduction
	neurotrophin TRK receptor signaling pathway
	apoptotic process
	positive regulation of apoptotic process
	negative regulation of apoptotic process
	endosomal transport
	response to stress
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of protein phosphorylation
	regulation of RNA biosynthetic process
	ubiquitin-dependent protein catabolic process
	autophagy
	protein heterooligomerization
	protein localization

Pathway	Dysregulation of Endosomal Trafficking in Amyotrophic Lateral Sclerosis
	mitochondrial autophagy pathway

Group	Transcription factors
	immune system process
	macroautophagy
	cell differentiation
	intracellular signal transduction
	apoptotic signaling pathway
	regulation of I-kappaB kinase-NF-kappaB signaling
	regulation of Ras protein signal transduction
	neurotrophin TRK receptor signaling pathway
	apoptotic process
	positive regulation of apoptotic process
	negative regulation of apoptotic process
	endosomal transport
	response to stress
	positive regulation of transcription from RNA polymerase II promoter
	positive regulation of protein phosphorylation
	regulation of RNA biosynthetic process
	transcription cofactor activity
	protein serine-threonine kinase activity
	ubiquitin-dependent protein catabolic process
	autophagy
	protein heterooligomerization
	protein localization
	receptor tyrosine kinase binding
	protein kinase binding
	protein kinase C binding
	SH2 domain binding
	ubiquitin binding
	K63-linked polyubiquitin binding
	protein homodimerization activity
	metal ion binding
	zinc ion binding
	nucleoplasm
	cytoplasmic mRNA processing body
	cytoplasm
	pre-autophagosomal structure
	cytosol
	endoplasmic reticulum
	endosome
	cytoplasmic vesicle
	autophagic vacuole
	lysosome
	late endosome
	aggresome
	nucleus

Alias	p60
	p62
	A170
	OSIL
	PDB3
	ZIP3
	p62B
	sequestosome-1
	EBIAP
	EBI3-associated protein p60
	oxidative stress induced like
	ubiquitin-binding protein p62
	EBI3-associated protein of 60 kDa
	phosphotyrosine independent ligand for the Lck SH2 domain p62
	phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa
	Osi
	STAP
	OSF-6
	RP23-319B15.3
	STONE14
	oxidative stress induced
	ZIP
	PKC-zeta-interacting protein
	protein kinase C-zeta-interacting protein
	PKC-zeta-interacting protein (ZIP)
	Phosphotyrosine independent ligand p62B for the Lck SH2 domain B-cell isofo
	PKC-zeta-interactive protein (ZIP)
	Paget disease of bone III
	sequestosome 1
	Paget disease of bone 3
	SQSTM1
	zip/p62
	induced oxidative stress-like
	SQSTM I
	sequestosome I
	likely ortholog of rat protein kinase C-zeta-interacting protein
	likely ortholog of rat protein kinase C-zeta-interactive protein
	LOC287253
	OTTMUSP00000005735
	p62/ZIP
	OTTMUSP00000005736
	OTTMUSP00000046654
	OSF VI
	A-170

Mouse chromosome position	11

OMIM ID	601530
	602080

Rat chromosome position	10q21

Hugo ID	11280

Human chromosome position	5q35

PIR ID	JC4978

Homologene ID	31202

MGI ID	107931

RGD ID	69287

MedScan ID	8878