| URN | urn:agi-llid:664 |
|---|---|
| Total Entities | 0 |
| Connectivity | 537 |
| Name | Bnip3 |
| Description | BCL2/adenovirus E1B 19kDa interacting protein 3 |
| Notes | This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. This protein contains a BH3 domain and a transmembrane domain, which have been associated with pro-apoptotic function. The dimeric mitochondrial protein encoded by this gene is known to induce apoptosis, even in the presence of BCL2. [provided by RefSeq, Mar 2011] |
| GO Molecular Function | GTPase binding |
|---|---|
| protein homodimerization activity | |
| protein heterodimerization activity |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| integral component of mitochondrial outer membrane | |
| mitochondrial membrane | |
| mitochondrial outer membrane | |
| nucleoplasm | |
| nuclear envelope | |
| mitochondrial envelope | |
| intracellular | |
| cytoplasm | |
| mitochondrion | |
| nucleus | |
| dendrite |
| GO Biological Process | defense response to virus |
|---|---|
| brown fat cell differentiation | |
| cell death | |
| regulation of mitochondrial membrane permeability | |
| mitochondrial outer membrane permeabilization | |
| negative regulation of mitochondrial fusion | |
| intrinsic apoptotic signaling pathway | |
| intrinsic apoptotic signaling pathway in response to hypoxia | |
| granzyme-mediated apoptotic signaling pathway | |
| positive regulation of release of cytochrome c from mitochondria | |
| positive regulation of protein complex disassembly | |
| apoptotic DNA fragmentation | |
| autophagic cell death | |
| apoptotic process | |
| positive regulation of apoptotic process | |
| negative regulation of apoptotic process | |
| mitochondrial fragmentation involved in apoptotic process | |
| neuron apoptotic process | |
| cellular response to hydrogen peroxide | |
| cellular response to cobalt ion | |
| cellular response to hypoxia | |
| response to hypoxia | |
| response to hyperoxia | |
| cellular response to mechanical stimulus | |
| positive regulation of mitochondrial fission | |
| positive regulation of autophagy | |
| reactive oxygen species metabolic process | |
| mitochondrial protein catabolic process | |
| modulation by virus of host morphology or physiology | |
| chromatin remodeling | |
| negative regulation of membrane potential |
| Pathway | IFNG-IFNR Expression Targets |
|---|---|
| mitochondrial autophagy pathway |
| Group | defense response to virus |
|---|---|
| brown fat cell differentiation | |
| cell death | |
| regulation of mitochondrial membrane permeability | |
| mitochondrial outer membrane permeabilization | |
| negative regulation of mitochondrial fusion | |
| intrinsic apoptotic signaling pathway | |
| intrinsic apoptotic signaling pathway in response to hypoxia | |
| granzyme-mediated apoptotic signaling pathway | |
| positive regulation of release of cytochrome c from mitochondria | |
| positive regulation of protein complex disassembly | |
| apoptotic DNA fragmentation | |
| autophagic cell death | |
| apoptotic process | |
| positive regulation of apoptotic process | |
| negative regulation of apoptotic process | |
| mitochondrial fragmentation involved in apoptotic process | |
| neuron apoptotic process | |
| cellular response to hydrogen peroxide | |
| cellular response to cobalt ion | |
| cellular response to hypoxia | |
| response to hypoxia | |
| response to hyperoxia | |
| cellular response to mechanical stimulus | |
| positive regulation of mitochondrial fission | |
| positive regulation of autophagy | |
| reactive oxygen species metabolic process | |
| mitochondrial protein catabolic process | |
| modulation by virus of host morphology or physiology | |
| chromatin remodeling | |
| negative regulation of membrane potential | |
| GTPase binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| membrane | |
| integral component of membrane | |
| integral component of mitochondrial outer membrane | |
| mitochondrial membrane | |
| mitochondrial outer membrane | |
| nucleoplasm | |
| nuclear envelope | |
| mitochondrial envelope | |
| intracellular | |
| cytoplasm | |
| mitochondrion | |
| nucleus | |
| dendrite |
| LocusLink ID | 664 |
|---|---|
| 12176 | |
| 84480 |
| Cell Localization | Mitochondrion |
|---|---|
| Mitochondrion outer membrane |
| GO ID | 0051020 |
|---|---|
| 0046982 | |
| 0042803 | |
| 0006309 | |
| 0006915 | |
| 0048102 | |
| 0050873 | |
| 0008219 | |
| 0071279 | |
| 0070301 | |
| 0071456 | |
| 0071260 | |
| 0006338 | |
| 0051607 | |
| 0008626 | |
| 1990144 | |
| 0043653 | |
| 0097345 | |
| 0035694 | |
| 0019048 | |
| 0043066 | |
| 0045837 | |
| 0010637 | |
| 0051402 | |
| 0043065 | |
| 0010508 | |
| 0090141 | |
| 0043243 | |
| 0090200 | |
| 0072593 | |
| 0046902 | |
| 0055093 | |
| 0001666 | |
| 0005737 | |
| 0030425 | |
| 0031307 | |
| 0031966 | |
| 0005741 | |
| 0005739 | |
| 0005635 | |
| 0005654 | |
| 0005634 | |
| 0097193 | |
| 0016021 | |
| 0005622 | |
| 0016020 | |
| 0005740 |
| Alias | NIP3 |
|---|---|
| BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 | |
| BCL2/adenovirus E1B interacting protein 1, NIP3 | |
| BCL2/adenovirus E1B 19kDa-interacting protein 1, NIP3 | |
| BCL2/adenovirus E1B 19 kDa-interacting protein 1, NIP3 | |
| BCL2/adenovirus E1B interacting protein 3 | |
| BCL2/adenovirus E1B 19 kDa-interacting protein 3 | |
| OTTMUSP00000026604 | |
| BNIP3 | |
| LOC100042570 | |
| MGC93043 | |
| nuclear BCL2/adenovirus E1B 19 kDa-interacting protein 3 | |
| mitochondrial protein BNip3 | |
| BCL2/adenovirus E1B 19kDa-interactive protein 1, NIP3 | |
| BCL2/adenovirus E1B 19kD interactive protein III | |
| OTTHUMP00000020752 | |
| 19 kDa BCL2/adenovirus E1B interactive protein III | |
| 19 kDa BCL2/adenovirus E1B interacting protein 3 | |
| BCL2/adenovirus E1B 19-kDa protein-interactive protein 3 | |
| 19 kDa BCL2/adenovirus E1B interactive protein 3 | |
| BCL2/adenovirus E1B 19-kDa protein-interactive protein III | |
| BCL2/adenovirus E1B 19kD interacting protein 3 | |
| BCL2/adenovirus E1B 19kD interacting protein III | |
| BCL2/adenovirus E1B 19kD interactive protein 3 | |
| BCL2/adenovirus E1B 19-kDa protein-interacting protein III | |
| 19 kDa BCL2/adenovirus E1B interacting protein III |
| Mouse chromosome position | 7 |
|---|
| OMIM ID | 603293 |
|---|
| Rat chromosome position | 1q41 |
|---|
| Hugo ID | 1084 |
|---|
| Human chromosome position | 10q26.3 |
|---|
| Swiss-Prot Accession | Q12983 |
|---|---|
| O55003 | |
| Q9ET45 | |
| O14620 | |
| Q96GP0 | |
| Q544Y4 |
| PIR ID | I38865 |
|---|
| Unigene ID | Hs.144873 |
|---|---|
| Mm.378890 | |
| Rn.2060 |
| KEGG ID | hsa:664 |
|---|---|
| mmu:12176 | |
| rno:84480 |
| Swiss-Prot ID | BNIP3_HUMAN |
|---|---|
| BNIP3_MOUSE |
| Ensembl ID | ENSMUSG00000078566 |
|---|---|
| ENSMUSP00000101718 | |
| ENSMUST00000106112 | |
| ENSRNOG00000017243 | |
| ENSRNOP00000023477 | |
| ENSRNOT00000023477 |
| Homologene ID | 2990 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 109326 |
|---|
| RGD ID | 620800 |
|---|
| MedScan ID | 664 |
|---|