Elsevier Inc. Fundc1 Atxn3 Sqstm1 canonical K48, K63 and noncanonical K6, K11 linkages deubiquitinases other autophagy/mitophagy components Map1lc3a Map1lc3b Gabarap Optn translocated cardiolipin Pink1_IMM Parkin substrates ---| mitochondria transport pathway Parkin substrates Park2 ---| mitochondria transport pathway Park2 Parkin substrates ---| mitochondria fusion pathway Map1lc3b ---- translocated cardiolipin casein kinase 2 autophagophore recruitment Pgam5 Bnip3l ---- Map1lc3b Bnip3l ---- Gabarap canonical K48, K63 and noncanonical K6, K11 linkages ---- Optn canonical K48, K63 and noncanonical K6, K11 linkages ---- Sqstm1 Src ---| Fundc1 Src ---> Fundc1 Pgam5 ---> Fundc1 Pgam5 --+> Fundc1 Fundc1 ---- Map1lc3b Bnip3 ---- Map1lc3b Fundc1 ---- Map1lc3a Bnip3l ---- Map1lc3a Map1lc3b ---- Optn Map1lc3b ---- Sqstm1 Map1lc3a ---- Optn Map1lc3a ---- Sqstm1 casein kinase 2 ---| Fundc1 casein kinase 2 ---> Fundc1 Src Pink1 ---> Pink1_IMM Parl ---| Pink1_IMM Parl Parl ---> Pink1_IMM Pink1 Tomm7 Tomm7 --+> Pink1 deubiquitinases ---> Parkin substrates Pink1 ---> Park2 Pink1 --+> Park2 Bnip3 ---- Map1lc3a Atxn3 ---| Park2 Ube2l3 Atxn3 ---- Ube2l3 mitochondria transport pathway mitochondria fusion pathway cardiolipin metabolic pathway Bnip3 hypoxia inducible factor pathway Bnip3l hypoxia inducible factor pathway ---> Bnip3l hypoxia inducible factor pathway ---> Bnip3 Park2 ---> canonical K48, K63 and noncanonical K6, K11 linkages Park2 ---> Parkin substrates