Protein Top2b

URN	urn:agi-llid:7155
Total Entities	0
Connectivity	222
Name	Top2b
Description	topoisomerase (DNA) II beta 180kDa
Notes	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008]

GO Molecular Function	DNA topoisomerase type II (ATP-hydrolyzing) activity
	isomerase activity
	DNA topoisomerase activity
	chromatin binding
	protein C-terminus binding
	enzyme binding
	histone deacetylase binding
	protein kinase C binding
	protein heterodimerization activity
	nucleotide binding
	ATP binding
	DNA binding
	DNA binding, bending
	metal ion binding

GO Biological Process	resolution of meiotic recombination intermediates
	ATP catabolic process
	forebrain development
	neuron migration
	axonogenesis
	chromosome segregation
	sister chromatid segregation
	mitotic DNA integrity checkpoint
	DNA metabolic process
	mitotic recombination
	DNA-dependent DNA replication
	DNA topological change

Pathway	Pancreatic Beta-cell Destruction in Diabetes Mellitus Type 1
	Cell Death Mediated by Cytotoxic Cells
	doxorubicin pharmacodynamics pathway
	doxorubicin response pathway

Group	Polymerase I transcription
	Polymerase II transcription
	Polymerase III transcription
	DNA replication
	Nucleolus organization and biogenesis
	resolution of meiotic recombination intermediates
	ATP catabolic process
	DNA topoisomerase type II (ATP-hydrolyzing) activity
	forebrain development
	neuron migration
	axonogenesis
	chromosome segregation
	sister chromatid segregation
	mitotic DNA integrity checkpoint
	isomerase activity
	DNA topoisomerase activity
	DNA metabolic process
	mitotic recombination
	DNA-dependent DNA replication
	DNA topological change
	chromatin binding
	protein C-terminus binding
	enzyme binding
	histone deacetylase binding
	protein kinase C binding
	protein heterodimerization activity
	nucleotide binding
	ATP binding
	DNA binding
	DNA binding, bending
	metal ion binding
	nucleoid
	nucleoplasm
	nucleolus
	synaptonemal complex
	WINAC complex
	heterochromatin
	cytosol
	chromosome
	nucleus

LocusLink ID	7155
	21974

Alias	TOPIIB
	top2beta
	DNA topoisomerase 2-beta
	topo II beta
	antigen MLAA-44
	topoisomerase IIb
	topoisomerase II beta
	U937 associated antigen
	DNA topoisomerase II beta
	DNA topoisomerase II, 180 kD
	DNA topoisomerase II, beta isozyme
	Top-2
	D230016L12Rik
	topoisomerase (DNA) II beta 180kDa
	RIKEN cDNA D230016L12 gene
	topoisomerase (DNA) II beta (180kD), topo II beta
	topoisomerase (DNA) II beta (180kD)
	topoisomerase (DNA) II beta
	topo 2 beta
	180 kDa topoisomerase (DNA) II beta
	OTTHUMP00000208318
	Top2b

Mouse chromosome position	14

OMIM ID	126431

Hugo ID	11990

Human chromosome position	3p24

PIR ID	S26730

Unigene ID	Hs.475733
	Mm.130362

KEGG ID	hsa:7155
	mmu:21974

Swiss-Prot ID	TOP2B_HUMAN
	TOP2B_MOUSE

EC Number	5.99.1.3

Homologene ID	68155

Organism	Homo sapiens
	Mus musculus

MGI ID	98791

RGD ID	1586156

MedScan ID	7155