| URN | urn:agi-llid:29107 |
|---|---|
| Total Entities | 0 |
| Connectivity | 48 |
| Name | Nxt1 |
| Description | NTF2-like export factor 1 |
| Notes | The protein encoded by this gene is located in the nuclear envelope. It has protein similarity to nuclear transport factor 2. This protein functions as a nuclear export factor in both RAN (Ras-related nuclear protein)- and CRM1 (required for chromosome region maintenance)-dependent pathways. It is found to stimulate the export of U1 snRNA in RAN- and CRM1-dependent pathways and the export of tRNA and mRNA in a CRM1-independent pathway. The encoded protein heterodimerizes with Tap protein and may regulate the ability of Tap protein to mediate nuclear mRNA export. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | Ran GTPase binding |
|---|
| GO Cellular Component | nuclear pore |
|---|---|
| nuclear speck | |
| intracellular | |
| cytoplasm | |
| nucleus |
| GO Biological Process | protein export from nucleus |
|---|---|
| transport | |
| protein transport | |
| mRNA transport | |
| RNA export from nucleus |
| Pathway | Protein Nuclear Import and Export |
|---|---|
| mRNA nuclear export pathway |
| Group | Nuclear export |
|---|---|
| protein export from nucleus | |
| transport | |
| protein transport | |
| mRNA transport | |
| RNA export from nucleus | |
| Ran GTPase binding | |
| nuclear pore | |
| nuclear speck | |
| intracellular | |
| cytoplasm | |
| nucleus |
| LocusLink ID | 29107 |
|---|---|
| 56488 | |
| 296219 |
| Cell Localization | Nucleus |
|---|---|
| Nucleus speckle | |
| Cytoplasm |
| GO ID | 0008536 |
|---|---|
| 0006405 | |
| 0006611 | |
| 0005737 | |
| 0005643 | |
| 0016607 | |
| 0051028 | |
| 0015031 | |
| 0006810 | |
| 0005622 | |
| 0005634 |
| Alias | P15 |
|---|---|
| MTR2 | |
| NTF2-related export protein 1 | |
| protein p15 | |
| NTX2-like export factor1 | |
| NUTF-like export factor 1 | |
| 1110001N02Rik | |
| RP23-377E1.1 | |
| NTF2-like export factor 1 | |
| RIKEN cDNA 1110001N02 gene | |
| OTTMUSP00000016720 | |
| OTTMUSP00000016719 | |
| OTTHUMP00000030420 | |
| NXT1 | |
| NXT I | |
| NUTF-like export factor I | |
| NTX2-like export factor I | |
| NTF2-related export protein I | |
| NTF2-like export factor I | |
| 1110001N02Rik(2) | |
| 1110001N02 |
| Mouse chromosome position | 2 |
|---|
| OMIM ID | 605811 |
|---|
| Rat chromosome position | 3q41 |
|---|
| Hugo ID | 15913 |
|---|
| Human chromosome position | 20p12-p11.2 |
|---|
| Swiss-Prot Accession | Q9UKK6 |
|---|---|
| Q9QZV9 | |
| B2RZ65 | |
| Q3THE3 | |
| Q9D1P7 |
| Unigene ID | Hs.516933 |
|---|---|
| Mm.34663 | |
| Rn.8541 |
| KEGG ID | hsa:29107 |
|---|---|
| mmu:56488 | |
| rno:296219 |
| Swiss-Prot ID | NXT1_MOUSE |
|---|---|
| NXT1_HUMAN |
| Ensembl ID | ENSG00000132661 |
|---|---|
| ENSP00000254998 | |
| ENST00000254998 | |
| ENSMUSG00000036992 | |
| ENSMUSP00000105587 | |
| ENSMUST00000109961 | |
| ENSMUSP00000038329 | |
| ENSMUST00000047177 | |
| ENSRNOG00000004700 | |
| ENSRNOP00000006205 | |
| ENSRNOT00000006205 |
| Homologene ID | 8301 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1929619 |
|---|
| RGD ID | 1309327 |
|---|
| MedScan ID | 29107 |
|---|