| URN | urn:agi-llid:10482 |
|---|---|
| Total Entities | 0 |
| Connectivity | 125 |
| Name | Nxf1 |
| Description | nuclear RNA export factor 1 |
| Notes | This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | nucleocytoplasmic transporter activity |
|---|---|
| nucleotide binding | |
| RNA binding | |
| mRNA binding |
| GO Cellular Component | cell |
|---|---|
| nuclear pore | |
| nuclear inclusion body | |
| nucleoplasm | |
| transcription export complex | |
| nuclear speck | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | poly(A)+ mRNA export from nucleus |
|---|---|
| gene expression | |
| mRNA export from nucleus | |
| transport | |
| mRNA transport | |
| RNA export from nucleus | |
| modulation by virus of host morphology or physiology |
| Pathway | Protein Nuclear Import and Export |
|---|---|
| mRNA nuclear export pathway |
| Group | Nuclear export |
|---|---|
| poly(A)+ mRNA export from nucleus | |
| gene expression | |
| mRNA export from nucleus | |
| transport | |
| nucleocytoplasmic transporter activity | |
| mRNA transport | |
| RNA export from nucleus | |
| modulation by virus of host morphology or physiology | |
| nucleotide binding | |
| RNA binding | |
| mRNA binding | |
| cell | |
| nuclear pore | |
| nuclear inclusion body | |
| nucleoplasm | |
| transcription export complex | |
| nuclear speck | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus |
| LocusLink ID | 10482 |
|---|---|
| 53319 | |
| 59087 |
| Cell Localization | Nucleus |
|---|---|
| Nucleoplasm | |
| Nucleus speckle | |
| Cytoplasm |
| GO ID | 0003729 |
|---|---|
| 0005487 | |
| 0000166 | |
| 0010467 | |
| 0006406 | |
| 0019048 | |
| 0016973 | |
| 0005829 | |
| 0042405 | |
| 0005643 | |
| 0016607 | |
| 0005654 | |
| 0000346 | |
| 0003723 | |
| 0006405 | |
| 0051028 | |
| 0006810 | |
| 0005623 | |
| 0005737 | |
| 0005622 | |
| 0005634 |
| Alias | TAP |
|---|---|
| MEX67 | |
| nuclear RNA export factor 1 | |
| mRNA export factor TAP | |
| tip-associated protein | |
| tip associating protein | |
| tip-associating protein | |
| Mvb1 | |
| Mex 67 homolog | |
| modifier of vibrator 1 | |
| tip associated protein | |
| nuclear RNA export factor 1 homolog | |
| Mex67h | |
| nuclear rna export factor 1 (mex67, yeast, homolog) | |
| nuclear RNA export factor 1 homolog (S. cerevisiae) | |
| nuclear RNA export factor I | |
| Nxf I | |
| Nxf1 | |
| DKFZp667o0311 | |
| LOC497739 | |
| Mex 67 homolog (S. cerevisiae) | |
| Mex67, yeast, homolog | |
| modifier of vibrator I | |
| Mvb I | |
| LOC360319 |
| Mouse chromosome position | 19 5.5 cM |
|---|
| OMIM ID | 602647 |
|---|
| Rat chromosome position | 1q43 |
|---|
| Hugo ID | 8071 |
|---|
| Human chromosome position | 11q12-q13 |
|---|
| Swiss-Prot Accession | Q59E96 |
|---|---|
| Q9UBU9 | |
| Q99JX7 | |
| O88984 | |
| O88985 | |
| Q3TJA5 | |
| B4E269 | |
| Q99799 | |
| Q9UQL2 |
| Unigene ID | Hs.523739 |
|---|---|
| Hs.601546 | |
| Mm.7271 | |
| Rn.159847 |
| KEGG ID | hsa:10482 |
|---|---|
| mmu:53319 | |
| rno:59087 |
| Swiss-Prot ID | NXF1_MOUSE |
|---|---|
| NXF1_RAT | |
| NXF1_HUMAN |
| Ensembl ID | ENSG00000162231 |
|---|---|
| ENSP00000453885 | |
| ENST00000531709 | |
| ENSP00000294172 | |
| ENST00000294172 | |
| ENSMUSG00000010097 | |
| ENSMUSP00000010241 | |
| ENSMUST00000010241 | |
| ENSRNOG00000019069 | |
| ENSRNOP00000026033 | |
| ENSRNOT00000026033 |
| Homologene ID | 38176 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1858330 |
|---|
| RGD ID | 62014 |
|---|
| MedScan ID | 10482 |
|---|