| URN | urn:agi-llid:7514 |
|---|---|
| Total Entities | 0 |
| Connectivity | 709 |
| Name | Xpo1 |
| Description | exportin 1 (CRM1 homolog, yeast) |
| Notes | The protein encoded by this gene mediates leucine-rich nuclear export signal (NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | transporter activity |
|---|---|
| protein transporter activity | |
| protein domain specific binding | |
| Ran GTPase binding | |
| RNA binding |
| GO Cellular Component | cell |
|---|---|
| annulate lamellae | |
| nucleoplasm | |
| nuclear envelope | |
| nucleolus | |
| Cajal body | |
| kinetochore | |
| ribonucleoprotein complex | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | regulation of centrosome duplication |
|---|---|
| mitotic cell cycle | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| protein export from nucleus | |
| regulation of protein export from nucleus | |
| response to drug | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of protein catabolic process | |
| RNA metabolic process | |
| mRNA metabolic process | |
| gene expression | |
| transport | |
| protein transport | |
| mRNA transport | |
| intracellular protein transport | |
| intracellular transport of virus | |
| viral process | |
| modulation by virus of host morphology or physiology | |
| viral life cycle | |
| protein localization to nucleus |
| Pathway | Kinetochore Assembly |
|---|---|
| Protein Nuclear Import and Export | |
| Mechanism of Cetuximab Resistance in Colorectal Cancer | |
| Nuclear EGFR | |
| mRNA nuclear export pathway |
| Group | Nuclear export |
|---|---|
| regulation of centrosome duplication | |
| mitotic cell cycle | |
| negative regulation of transforming growth factor beta receptor signaling pathway | |
| transforming growth factor beta receptor signaling pathway | |
| protein export from nucleus | |
| regulation of protein export from nucleus | |
| response to drug | |
| negative regulation of transcription from RNA polymerase II promoter | |
| regulation of protein catabolic process | |
| RNA metabolic process | |
| mRNA metabolic process | |
| gene expression | |
| transport | |
| transporter activity | |
| protein transporter activity | |
| protein transport | |
| mRNA transport | |
| intracellular protein transport | |
| intracellular transport of virus | |
| viral process | |
| modulation by virus of host morphology or physiology | |
| viral life cycle | |
| protein localization to nucleus | |
| protein domain specific binding | |
| Ran GTPase binding | |
| RNA binding | |
| cell | |
| annulate lamellae | |
| nucleoplasm | |
| nuclear envelope | |
| nucleolus | |
| Cajal body | |
| kinetochore | |
| ribonucleoprotein complex | |
| intracellular | |
| cytoplasm | |
| cytosol | |
| nucleus |
| LocusLink ID | 7514 |
|---|---|
| 103573 | |
| 85252 |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| Nucleoplasm | |
| Cajal body | |
| Nucleolus |
| GO ID | 0003723 |
|---|---|
| 0008536 | |
| 0019904 | |
| 0008565 | |
| 0005215 | |
| 0016070 | |
| 0010467 | |
| 0075733 | |
| 0016071 | |
| 0051028 | |
| 0000278 | |
| 0019048 | |
| 0000122 | |
| 0030512 | |
| 0006611 | |
| 0034504 | |
| 0010824 | |
| 0042176 | |
| 0046825 | |
| 0042493 | |
| 0007179 | |
| 0019058 | |
| 0016032 | |
| 0015030 | |
| 0005642 | |
| 0005737 | |
| 0005829 | |
| 0000776 | |
| 0005635 | |
| 0005730 | |
| 0005654 | |
| 0030529 | |
| 0006886 | |
| 0015031 | |
| 0006810 | |
| 0005623 | |
| 0005622 | |
| 0005634 |
| Alias | emb |
|---|---|
| CRM1 | |
| exp1 | |
| exportin-1 | |
| CRM1, yeast, homolog | |
| exportin 1 (CRM1, yeast, homolog) | |
| chromosome region maintenance 1 protein homolog | |
| exportin-1 (required for chromosome region maintenance) | |
| AA420417 | |
| RP23-305E10.1 | |
| exportin Crm1 | |
| OTTHUMP00000201494 | |
| OTTHUMP00000201496 | |
| OTTMUSP00000005444 | |
| OTTMUSP00000005445 | |
| Xpo I | |
| chromosomal region maintenance protein 1 | |
| Xpo1 | |
| exportin 1, CRM1 homolog | |
| CRM I | |
| CRM1 homolog | |
| DKFZp686B1823 | |
| exportin 1 | |
| exportin 1 (CRM1 homolog, yeast) | |
| exportin I |
| Mouse chromosome position | 11 |
|---|
| OMIM ID | 602559 |
|---|
| Rat chromosome position | 14q22 |
|---|
| Hugo ID | 12825 |
|---|
| Human chromosome position | 2p15 |
|---|
| Swiss-Prot Accession | B3KWD0 |
|---|---|
| O14980 | |
| Q6P5F9 | |
| Q8BYY5 | |
| Q80U96 | |
| A6NL14 | |
| A8K1K5 | |
| D6W5E2 | |
| Q63HP8 | |
| Q68CP3 | |
| Q99433 |
| Unigene ID | Hs.370770 |
|---|---|
| Mm.217547 | |
| Rn.34087 |
| KEGG ID | hsa:7514 |
|---|---|
| mmu:103573 | |
| rno:85252 |
| Swiss-Prot ID | XPO1_RAT |
|---|---|
| XPO1_HUMAN | |
| XPO1_MOUSE |
| Ensembl ID | ENSG00000082898 |
|---|---|
| ENSP00000384863 | |
| ENST00000401558 | |
| ENSMUSG00000020290 | |
| ENSMUSP00000105178 | |
| ENSMUST00000109551 | |
| ENSMUSP00000020538 | |
| ENSMUST00000020538 | |
| ENSRNOG00000009935 | |
| ENSRNOP00000014062 | |
| ENSRNOT00000014062 |
| Homologene ID | 2554 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2144013 |
|---|
| RGD ID | 620517 |
|---|
| MedScan ID | 7514 |
|---|