| URN | urn:agi-llid:2733 |
|---|---|
| Total Entities | 0 |
| Connectivity | 60 |
| Name | Gle1 |
| Description | GLE1 RNA export mediator |
| Notes | This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| GO Cellular Component | nuclear pore |
|---|---|
| cytoplasm | |
| nucleus |
| GO Biological Process | poly(A)+ mRNA export from nucleus |
|---|---|
| mRNA export from nucleus | |
| transport | |
| protein transport | |
| mRNA transport |
| Pathway | mRNA nuclear export pathway |
|---|
| Group | Nuclear export |
|---|---|
| poly(A)+ mRNA export from nucleus | |
| mRNA export from nucleus | |
| transport | |
| protein transport | |
| mRNA transport | |
| nuclear pore | |
| cytoplasm | |
| nucleus |
| LocusLink ID | 2733 |
|---|---|
| 74412 | |
| 362098 |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| Nuclear pore complex |
| GO ID | 0006406 |
|---|---|
| 0016973 | |
| 0015031 | |
| 0005737 | |
| 0005643 | |
| 0051028 | |
| 0006810 | |
| 0005634 |
| Alias | LCCS |
|---|---|
| GLE1L | |
| LCCS1 | |
| hGLE1 | |
| nucleoporin GLE1 | |
| GLE1-like protein | |
| GLE1-like, RNA export mediator | |
| GLE1 RNA export mediator homolog | |
| AA553313 | |
| 4933405K21Rik | |
| RP23-443G7.5 | |
| GLE1 RNA export mediator-like (yeast | |
| OTTMUSP00000018090 | |
| hGLE I | |
| MGC116182 | |
| OTTHUMP00000022281 | |
| LCCS gene | |
| lethal congenital contracture syndrome 1 gene | |
| OTTHUMP00000022280 | |
| GLE I | |
| 4933405K21 | |
| GLE1 | |
| GLE1 ( homolog)-like, RNA export mediator | |
| GLE1 (yeast homolog)-like, RNA export mediator | |
| GLE1 RNA export mediator | |
| GLE1 RNA export mediator (yeast) | |
| GLE1 RNA export mediator homolog (yeast) | |
| GLE1 RNA export mediator-like |
| Mouse chromosome position | 2 |
|---|
| OMIM ID | 603371 |
|---|---|
| 611890 | |
| 253310 |
| Rat chromosome position | 3p12 |
|---|
| Hugo ID | 4315 |
|---|
| Human chromosome position | 9q34.11 |
|---|
| Swiss-Prot Accession | Q53GS7 |
|---|---|
| B3KMG0 | |
| Q8R322 | |
| Q4KLN4 | |
| O75458 | |
| Q53GT9 | |
| Q5VVU1 | |
| Q8NCP6 | |
| Q9UFL6 | |
| A3KGV8 | |
| Q3TT10 | |
| Q3TU23 | |
| Q3UD65 | |
| Q8BT16 | |
| Q9D4A6 |
| PIR ID | T17316 |
|---|
| Unigene ID | Hs.522418 |
|---|---|
| Mm.275121 | |
| Rn.162648 |
| KEGG ID | hsa:2733 |
|---|---|
| mmu:74412 | |
| rno:362098 |
| Swiss-Prot ID | GLE1_HUMAN |
|---|---|
| GLE1_RAT | |
| GLE1_MOUSE |
| Ensembl ID | ENSG00000119392 |
|---|---|
| ENSP00000308622 | |
| ENST00000309971 | |
| ENSP00000361856 | |
| ENST00000372770 |
| Homologene ID | 20379 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1921662 |
|---|
| RGD ID | 1307329 |
|---|
| MedScan ID | 2733 |
|---|