| URN | urn:agi-llid:56000 |
|---|---|
| Total Entities | 0 |
| Connectivity | 25 |
| Name | Nxf3 |
| Description | nuclear RNA export factor 3 |
| Notes | This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene has shortened LRR and ubiquitin-associated domains and its RDB is unable to bind RNA. It is located in the nucleoplasm but is not associated with either the nuclear envelope or the nucleolus. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | nucleotide binding |
|---|---|
| RNA binding | |
| mRNA binding |
| GO Cellular Component | cell |
|---|---|
| nuclear RNA export factor complex | |
| intracellular | |
| cytoplasm | |
| nucleus |
| GO Biological Process | poly(A)+ mRNA export from nucleus |
|---|---|
| mRNA export from nucleus |
| Pathway | mRNA nuclear export pathway |
|---|
| Group | Nuclear export |
|---|---|
| poly(A)+ mRNA export from nucleus | |
| mRNA export from nucleus | |
| nucleotide binding | |
| RNA binding | |
| mRNA binding | |
| cell | |
| nuclear RNA export factor complex | |
| intracellular | |
| cytoplasm | |
| nucleus |
| LocusLink ID | 56000 |
|---|---|
| 245610 | |
| 302591 |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm |
| GO ID | 0003729 |
|---|---|
| 0000166 | |
| 0006406 | |
| 0016973 | |
| 0005737 | |
| 0042272 | |
| 0005634 | |
| 0005623 | |
| 0005622 | |
| 0003723 |
| Alias | LL0XNC01-221F2.3 |
|---|---|
| nuclear RNA export factor 3 | |
| TAPL-3 | |
| TAP-like protein 3 | |
| Gm384 | |
| RP23-1A3.5 | |
| RGD1564923 | |
| TAPL3 | |
| OTTHUMP00000023727 | |
| OTTMUSP00000020293 | |
| nuclear RNA export factor III | |
| LOC279632 | |
| NXF3 |
| Mouse chromosome position | X 57.38 cM |
|---|
| OMIM ID | 300316 |
|---|
| Rat chromosome position | Xq35 |
|---|
| Hugo ID | 8073 |
|---|
| Human chromosome position | Xq22 |
|---|
| Swiss-Prot Accession | Q9H4D5 |
|---|---|
| Q4ZGD9 | |
| F1M355 | |
| Q5H9I1 | |
| Q9H1A9 |
| Unigene ID | Hs.60386 |
|---|---|
| Mm.336244 | |
| Rn.198426 |
| KEGG ID | hsa:56000 |
|---|---|
| mmu:245610 | |
| rno:302591 |
| Swiss-Prot ID | NXF3_HUMAN |
|---|
| Ensembl ID | ENSG00000147206 |
|---|---|
| ENSP00000378504 | |
| ENST00000395065 | |
| ENSMUSG00000057000 | |
| ENSMUSP00000079730 | |
| ENSMUST00000080929 | |
| ENSRNOG00000028751 | |
| ENSRNOP00000032378 | |
| ENSRNOT00000037823 |
| Homologene ID | 19406 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 2685230 |
|---|
| RGD ID | 1564923 |
|---|
| MedScan ID | 56000 |
|---|