Protein Eif4e

URN	urn:agi-llid:1977
Total Entities	0
Connectivity	1025
Name	Eif4e
Description	eukaryotic translation initiation factor 4E
Notes	The protein encoded by this gene is a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of cellular mRNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the mRNA. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GO Molecular Function	translation initiation factor activity
	eukaryotic initiation factor 4G binding
	RNA binding
	RNA cap binding

GO Cellular Component	protein complex
	eukaryotic translation initiation factor 4F complex
	mRNA cap binding complex
	cytoplasmic stress granule
	chromatoid body
	cytoplasmic mRNA processing body
	RISC complex
	cytoplasm
	cytosol

GO Biological Process	lung development
	G1-S transition of mitotic cell cycle
	positive regulation of mitotic cell cycle
	cytokine-mediated signaling pathway
	insulin receptor signaling pathway
	regulation of translation
	translational initiation
	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
	nuclear-transcribed mRNA poly(A) tail shortening
	RNA metabolic process
	mRNA metabolic process
	cellular protein metabolic process
	translation
	gene expression
	mRNA export from nucleus
	modulation by virus of host morphology or physiology

Pathway	Translation
	Myostatin-IGF1 Crosstalk in Skeletal Muscles
	IGF1 in Muscle Hypertrophy
	Acute Myeloid Leukemia Overview
	IL-6/IGF-1/VEGFA in Multiple Myeloma
	Multiple Myeloma Overview
	Chronic Myeloid Leukemia Overview
	B-cell Acute Lymphoblastic Leukemia Overview
	T-cell Acute Lymphoblastic Leukemia Overview
	Mantle Cell Lymphoma Overview
	PI3K/AKT/MTOR, NF-kB and BCR Signaling Deregulation in Mantle Cell Lymphoma
	Proteins Involved in Pathogenesis of Mantle Cell Lymphoma
	Insulin Influence on Protein Synthesis
	Cardiovascular Effects of Hyperthyroidism
	Deregulation of Cell Cycle in Melanoma
	Mechanisms of Cardiomyocyte Hypertrophy in Hypertrophic Cardiomyopathy
	Hypertrophic Cardiomyopathy Overview
	Epilepsies Associated with Blood-Brain Barrier Disruption
	mTOR Hyperactivation after Status Epilepticus
	Proposed Mechanisms of Antiepileptic Effects of a Ketogenic Diet
	Preconditioning Ischemia
	ROS in Angiotensin-Mediated Cardiovascular Remodeling and Hypertrophy
	NGF/AP-1/TP53/MYC Expression Targets
	NGF/SMAD3/NF-kB Expression Targets
	GH1-GHR/NF-kB/ELK-SRF/MYC Expression Targets
	GH1-GHR/STAT Expression Targets
	GH1-PRLR Expression Targets
	Prostaglandin F Expression Targets
	IGF1/STAT Expression Targets
	IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets
	IGF1/MEF/MYOD/MYOG Expression Targets
	mRNA nuclear export pathway

Group	Translation
	lung development
	G1-S transition of mitotic cell cycle
	positive regulation of mitotic cell cycle
	cytokine-mediated signaling pathway
	insulin receptor signaling pathway
	regulation of translation
	translational initiation
	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
	nuclear-transcribed mRNA poly(A) tail shortening
	RNA metabolic process
	mRNA metabolic process
	translation initiation factor activity
	cellular protein metabolic process
	translation
	gene expression
	mRNA export from nucleus
	modulation by virus of host morphology or physiology
	eukaryotic initiation factor 4G binding
	RNA binding
	RNA cap binding
	protein complex
	eukaryotic translation initiation factor 4F complex
	mRNA cap binding complex
	cytoplasmic stress granule
	chromatoid body
	cytoplasmic mRNA processing body
	RISC complex
	cytoplasm
	cytosol
	Secreted proteins
	Biofluids assayable substances

Cell Localization	Cytoplasm
	P-body

Alias	CBP
	EIF4F
	AUTS19
	EIF4E1
	EIF4EL1
	eukaryotic translation initiation factor 4E
	eIF-4E
	eIF-4F 25 kDa subunit
	mRNA cap-binding protein
	eukaryotic translation initiation factor 4E-like 1
	If4e
	EG668879
	Eif4e-ps
	eukaryotic translation initiation factor 4E-like I
	IF4E_HUMAN
	MGC103177
	MGC111573
	MGC93265
	mRNA cap binding protein
	OTTHUMP00000219703
	translation initiating factor eIF-4E
	EIF4EL I
	EIF4E
	translation initiation factor eIF-4E
	Eukaryotic initiation factor 4E
	Eukaryotic translation initiating factor 4E
	eukaryotic translation initiating factor 4E-like 1
	eukaryotic translation initiating factor 4E-like I

Mouse chromosome position	3 64.3 cM

OMIM ID	133440
	615091

Rat chromosome position	2q44

Hugo ID	3287

Human chromosome position	4q21-q25

Homologene ID	123817

MGI ID	95305

RGD ID	69647

MedScan ID	1977