Protein Ran

URN	urn:agi-llid:5901
Total Entities	0
Connectivity	273
Name	Ran
Description	RAN, member RAS oncogene family
Notes	RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]

GO Molecular Function	GTPase activity
	transcription coactivator activity
	chromatin binding
	protein domain specific binding
	androgen receptor binding
	nucleotide binding
	GDP binding
	GTP binding

GO Biological Process	spermatid development
	small molecule metabolic process
	GTP catabolic process
	cell division
	cell cycle
	actin cytoskeleton organization
	microtubule cytoskeleton organization
	mitosis
	mitotic spindle organization
	signal transduction
	small GTPase mediated signal transduction
	androgen receptor signaling pathway
	protein export from nucleus
	protein import into nucleus
	positive regulation of transcription, DNA-templated
	DNA metabolic process
	gene expression
	transport
	protein transport
	RNA export from nucleus
	intracellular protein transport
	nucleocytoplasmic transport
	intracellular transport of virus
	viral process
	modulation by virus of host morphology or physiology
	viral life cycle
	cellular protein localization
	cellular protein complex localization
	positive regulation of protein binding

Pathway	RNA Gene Silencing
	Protein Nuclear Import and Export
	mRNA nuclear export pathway

Group	Protein nucleus import
	Nuclear export
	Oncogenes
	spermatid development
	small molecule metabolic process
	GTP catabolic process
	GTPase activity
	cell division
	cell cycle
	actin cytoskeleton organization
	microtubule cytoskeleton organization
	mitosis
	mitotic spindle organization
	signal transduction
	small GTPase mediated signal transduction
	androgen receptor signaling pathway
	protein export from nucleus
	protein import into nucleus
	positive regulation of transcription, DNA-templated
	transcription coactivator activity
	DNA metabolic process
	gene expression
	transport
	protein transport
	RNA export from nucleus
	intracellular protein transport
	nucleocytoplasmic transport
	intracellular transport of virus
	viral process
	modulation by virus of host morphology or physiology
	viral life cycle
	cellular protein localization
	cellular protein complex localization
	positive regulation of protein binding
	chromatin binding
	protein domain specific binding
	androgen receptor binding
	nucleotide binding
	GDP binding
	GTP binding
	nuclear pore
	nucleoplasm
	chromatin
	protein complex
	cytoplasm
	cytosol
	melanosome
	nucleus

Alias	TC4
	Gsp1
	ARA24
	OK/SW-cl.81
	GTP-binding nuclear protein Ran
	RanGTPase
	GTPase Ran
	ras-like protein TC4
	member RAS oncogene family
	ras-related nuclear protein
	guanosine triphosphatase Ran
	androgen receptor-associated protein 24
	Ras related nuclear protein
	RASL2 VIII
	RAN small monomeric GTPases
	RAN, member RAS oncogene family
	Ran/M2
	RAN_HUMAN
	Rasl2 IX
	RAN small monomeric GTPase
	Rasl2-9
	RAS-like, family 2, locus
	RAS-like, family 2, locus 9
	ran GTP-binding protein
	TC4 protein
	Ran GTPase
	RASL2-8
	ran GTP binding protein
	GTP-binding nuclear protein RAN (Guillardia theta)
	RAN
	1A2K_D
	1A2K_E
	androgen receptor associated protein 24
	1A2K_C
	OTTMUSP00000018391
	OTTMUSP00000018390
	OTTHUMP00000166078
	GTP-binding Ran/TC4
	LOC87046
	LOC65666
	1700009N14
	OTTHUMP00000166102

Mouse chromosome position	5

OMIM ID	601179

Rat chromosome position	12q14

Hugo ID	9846

Human chromosome position	12q24.3

PIR ID	A44393

Swiss-Prot ID	RAN_RAT
	RAN_HUMAN

Homologene ID	68143

MGI ID	1333112

RGD ID	620367

MedScan ID	5901