| URN | urn:agi-llid:5905 |
|---|---|
| Total Entities | 0 |
| Connectivity | 125 |
| Name | Rangap1 |
| Description | Ran GTPase activating protein 1 |
| Notes | This gene encodes a protein that associates with the nuclear pore complex and participates in the regulation of nuclear transport. The encoded protein interacts with Ras-related nuclear protein 1 (RAN) and regulates guanosine triphosphate (GTP)-binding and exchange. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| GO Molecular Function | GTPase activator activity |
|---|---|
| Ran GTPase activator activity |
| GO Cellular Component | membrane |
|---|---|
| nuclear pore | |
| nuclear membrane | |
| chromosome, centromeric region | |
| kinetochore | |
| condensed chromosome kinetochore | |
| spindle pole | |
| cytoplasm | |
| cytosol | |
| perinuclear region of cytoplasm | |
| cytoskeleton | |
| chromosome | |
| nucleus |
| GO Biological Process | positive regulation of Ran GTPase activity |
|---|---|
| mitotic cell cycle | |
| signal transduction | |
| negative regulation of protein export from nucleus |
| Pathway | Histone Sumoylation |
|---|---|
| Kinetochore Assembly | |
| Protein Nuclear Import and Export | |
| mRNA nuclear export pathway |
| Group | Nuclear pore organization and biogenesis |
|---|---|
| Protein nucleus import | |
| Nuclear export | |
| GTPase activator activity | |
| Ran GTPase activator activity | |
| positive regulation of Ran GTPase activity | |
| mitotic cell cycle | |
| signal transduction | |
| negative regulation of protein export from nucleus | |
| membrane | |
| nuclear pore | |
| nuclear membrane | |
| chromosome, centromeric region | |
| kinetochore | |
| condensed chromosome kinetochore | |
| spindle pole | |
| cytoplasm | |
| cytosol | |
| perinuclear region of cytoplasm | |
| cytoskeleton | |
| chromosome | |
| nucleus | |
| Biofluids assayable substances |
| LocusLink ID | 5905 |
|---|---|
| 19387 | |
| 362965 |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| Nucleus membrane | |
| Chromosome | |
| Centromere | |
| Kinetochore | |
| Cytoskeleton | |
| Spindle | |
| Spindle pole |
| GO ID | 0005098 |
|---|---|
| 0000278 | |
| 0046826 | |
| 0032853 | |
| 0007165 | |
| 0000777 | |
| 0005737 | |
| 0005829 | |
| 0000776 | |
| 0031965 | |
| 0005643 | |
| 0048471 | |
| 0000922 | |
| 0005096 | |
| 0005694 | |
| 0000775 | |
| 0005856 | |
| 0016020 | |
| 0005634 |
| Alias | SD |
|---|---|
| Fug1 | |
| RANGAP | |
| RP4-756G23.7 | |
| ran GTPase-activating protein 1 | |
| segregation distortion | |
| segregation distorter homolog | |
| C79654 | |
| mKIAA1835 | |
| RAN GTPase activating protein 1 | |
| segregation distortion homolog | |
| Rangap I | |
| Rangap1 | |
| segregating distortion (Drosophila) | |
| segregation distortion (Drosophila) | |
| segregation distortion (from Drosophila) | |
| Ran GTPase activating protein I | |
| Fug I | |
| KIAA1835 | |
| MGC20266 | |
| OTTHUMP00000028918 | |
| OTTHUMP00000198756 | |
| OTTHUMP00000198757 | |
| Danforth's short tail |
| Mouse chromosome position | 15 38.21 cM |
|---|
| OMIM ID | 602362 |
|---|
| Rat chromosome position | 7q34 |
|---|
| Hugo ID | 9854 |
|---|
| Human chromosome position | 22q13 |
|---|
| Swiss-Prot Accession | P46060 |
|---|---|
| Q9BSK3 | |
| F8W7I9 | |
| P46061 | |
| F1MAA5 | |
| Q60801 | |
| Q6NZB5 | |
| Q96JJ2 |
| PIR ID | A36983 |
|---|---|
| T52070 | |
| JC5300 |
| Unigene ID | Hs.183800 |
|---|---|
| Mm.270975 | |
| Mm.475271 | |
| Rn.107099 |
| KEGG ID | hsa:5905 |
|---|---|
| mmu:19387 | |
| rno:362965 |
| Swiss-Prot ID | RAGP1_MOUSE |
|---|---|
| RAGP1_HUMAN |
| Ensembl ID | ENSG00000100401 |
|---|---|
| ENSP00000385866 | |
| ENST00000405486 | |
| ENSP00000348577 | |
| ENST00000356244 | |
| ENSMUSG00000022391 | |
| ENSMUSP00000057771 | |
| ENSMUST00000052374 | |
| ENSMUSP00000126849 | |
| ENSMUST00000170134 | |
| ENSRNOG00000031789 | |
| ENSRNOP00000050029 | |
| ENSRNOT00000052098 |
| Homologene ID | 55700 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 103071 |
|---|
| RGD ID | 1310380 |
|---|
| MedScan ID | 5905 |
|---|