Protein Ranbp2

URN	urn:agi-llid:5903
Total Entities	0
Connectivity	278
Name	Ranbp2
Description	RAN binding protein 2
Notes	RAN is a small GTP-binding protein of the RAS superfamily that is associated with the nuclear membrane and is thought to control a variety of cellular functions through its interactions with other proteins. This gene encodes a very large RAN-binding protein that immunolocalizes to the nuclear pore complex. The protein is a giant scaffold and mosaic cyclophilin-related nucleoporin implicated in the Ran-GTPase cycle. The encoded protein directly interacts with the E2 enzyme UBC9 and strongly enhances SUMO1 transfer from UBC9 to the SUMO1 target SP100. These findings place sumoylation at the cytoplasmic filaments of the nuclear pore complex and suggest that, for some substrates, modification and nuclear import are linked events. This gene is partially duplicated in a gene cluster that lies in a hot spot for recombination on chromosome 2q. [provided by RefSeq, Jul 2008]

GO Molecular Function	ligase activity
	peptidyl-prolyl cis-trans isomerase activity
	Ran GTPase binding
	RNA binding
	metal ion binding
	zinc ion binding

GO Biological Process	small molecule metabolic process
	regulation of gluconeogenesis involved in cellular glucose homeostasis
	negative regulation of glucokinase activity
	transmembrane transport
	mitotic nuclear envelope disassembly
	mitotic cell cycle
	cytokine-mediated signaling pathway
	protein import into nucleus
	hexose transport
	glucose transport
	regulation of glucose transport
	protein folding
	protein sumoylation
	carbohydrate metabolic process
	transport
	intracellular transport
	protein transport
	mRNA transport
	viral process

Pathway	Histone Sumoylation
	mRNA nuclear export pathway

Group	Nuclear pore organization and biogenesis
	Protein nucleus import
	Nuclear export
	small molecule metabolic process
	regulation of gluconeogenesis involved in cellular glucose homeostasis
	negative regulation of glucokinase activity
	transmembrane transport
	mitotic nuclear envelope disassembly
	mitotic cell cycle
	cytokine-mediated signaling pathway
	protein import into nucleus
	hexose transport
	glucose transport
	regulation of glucose transport
	ligase activity
	peptidyl-prolyl cis-trans isomerase activity
	protein folding
	protein sumoylation
	carbohydrate metabolic process
	transport
	intracellular transport
	protein transport
	mRNA transport
	viral process
	Ran GTPase binding
	RNA binding
	metal ion binding
	zinc ion binding
	membrane
	nuclear pore nuclear basket
	nuclear pore
	nuclear membrane
	nuclear inclusion body
	cytosol
	mitochondrion
	nucleus

Alias	ANE1
	TRP1
	TRP2
	ADANE
	IIAE3
	NUP358
	E3 SUMO-protein ligase RanBP2
	P270
	nucleoporin 358
	nucleoporin Nup358
	358 kDa nucleoporin
	ran-binding protein 2
	transformation-related protein 2
	nuclear pore complex protein Nup358
	acute necrotizing encephalopathy 1 (autosomal dominant)
	AI256741
	A430087B05Rik
	RGD1560047
	RANBP2
	acute necrotizing encephalopathy 1 (autosomal dominant) gene
	RIKEN cDNA A430087B05 gene
	acute necrotizing encephalopathy 1 (autosomal dominant) locus
	LOC215993
	RAN binding protein II
	LOC100911178
	RAN binding protein 2
	A430087B05
	OTTHUMP00000203472

Mouse chromosome position	10 29.34 cM

OMIM ID	601181
	608033

Rat chromosome position	20q11

Hugo ID	9848

Human chromosome position	2q12.3

PIR ID	S58884
	S57968

Swiss-Prot ID	RBP2_HUMAN
	RBP2_MOUSE

EC Number	5.2.1.8
	6.3.2.-

Homologene ID	68510

MGI ID	894323

RGD ID	1560047

MedScan ID	5903