| URN | urn:agi-llid:1994 |
|---|---|
| Total Entities | 0 |
| Connectivity | 652 |
| Name | Elavl1 |
| Description | ELAV like RNA binding protein 1 |
| Notes | The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012] |
| GO Molecular Function | protein kinase binding |
|---|---|
| nucleotide binding | |
| nucleic acid binding | |
| RNA binding | |
| AU-rich element binding | |
| double-stranded RNA binding | |
| mRNA binding | |
| mRNA 3'-UTR binding | |
| mRNA 3'-UTR AU-rich region binding |
| GO Cellular Component | nucleoplasm |
|---|---|
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | multicellular organismal development |
|---|---|
| positive regulation of translation | |
| regulation of translation | |
| mRNA stabilization | |
| 3'-UTR-mediated mRNA stabilization | |
| RNA metabolic process | |
| mRNA metabolic process | |
| gene expression |
| Pathway | mRNA nuclear export pathway |
|---|
| Group | multicellular organismal development |
|---|---|
| positive regulation of translation | |
| regulation of translation | |
| mRNA stabilization | |
| 3'-UTR-mediated mRNA stabilization | |
| RNA metabolic process | |
| mRNA metabolic process | |
| gene expression | |
| protein kinase binding | |
| nucleotide binding | |
| nucleic acid binding | |
| RNA binding | |
| AU-rich element binding | |
| double-stranded RNA binding | |
| mRNA binding | |
| mRNA 3'-UTR binding | |
| mRNA 3'-UTR AU-rich region binding | |
| nucleoplasm | |
| cytoplasm | |
| cytosol | |
| nucleus | |
| Secreted proteins |
| LocusLink ID | 1994 |
|---|---|
| 15568 | |
| 363854 |
| Cell Localization | Cytoplasm |
|---|---|
| Nucleus |
| GO ID | 0017091 |
|---|---|
| 0003723 | |
| 0003725 | |
| 0035925 | |
| 0003729 | |
| 0000166 | |
| 0019901 | |
| 0070935 | |
| 0016070 | |
| 0010467 | |
| 0016071 | |
| 0048255 | |
| 0007275 | |
| 0045727 | |
| 0005737 | |
| 0005829 | |
| 0005654 | |
| 0005634 | |
| 0003730 | |
| 0003676 | |
| 0006417 |
| Alias | HUR |
|---|---|
| Hua | |
| MelG | |
| ELAV1 | |
| ELAV-like protein 1 | |
| Hu antigen R | |
| hu-antigen R | |
| embryonic lethal, abnormal vision, drosophila, homolog-like 1 | |
| ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) | |
| W91709 | |
| 2410055N02Rik | |
| HU-antigen A | |
| elav-like generic protein | |
| ELAV like 1 | |
| Embryonic lethal, abnormal vision, drosophila, homolog-like I | |
| HuR protein | |
| RIKEN cDNA 2410055N02 gene | |
| ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) | |
| ELAV like RNA binding protein 1 | |
| Embryonic lethal, abnormal vision, drosophila, homolog-like | |
| elav (embryonic lethal, abnormal vision, drosophila)-like I | |
| ELAV-like protein I | |
| ELAV I | |
| 2410055N02 | |
| Elavl I | |
| Elavl1 | |
| elav (embryonic lethal, abnormal vision, drosophila)-like 1 |
| Mouse chromosome position | 8 2.0 cM |
|---|
| OMIM ID | 603466 |
|---|
| Rat chromosome position | 12p12 |
|---|
| Hugo ID | 3312 |
|---|
| Human chromosome position | 19p13.2 |
|---|
| Swiss-Prot Accession | Q15717 |
|---|---|
| B4DVB8 | |
| P70372 | |
| B5DF91 | |
| Q53XN6 | |
| Q9BTT1 | |
| Q60745 | |
| Q78QY3 |
| PIR ID | I49144 |
|---|
| Unigene ID | Hs.184492 |
|---|---|
| Hs.713744 | |
| Mm.119162 | |
| Rn.216517 |
| KEGG ID | hsa:1994 |
|---|---|
| mmu:15568 | |
| rno:363854 |
| Swiss-Prot ID | ELAV1_HUMAN |
|---|---|
| ELAV1_MOUSE |
| Ensembl ID | ENSG00000066044 |
|---|---|
| ENSP00000385269 | |
| ENST00000407627 | |
| ENSMUSG00000040028 | |
| ENSMUSP00000096549 | |
| ENSMUST00000098950 | |
| ENSRNOG00000001069 | |
| ENSRNOP00000001415 | |
| ENSRNOT00000001415 |
| Homologene ID | 20367 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1100851 |
|---|
| RGD ID | 1308649 |
|---|
| MedScan ID | 1994 |
|---|