| URN | urn:agi-llid:7153 |
|---|---|
| Total Entities | 0 |
| Connectivity | 383 |
| Name | TOP2A |
| Description | topoisomerase (DNA) II alpha 170kDa |
| Notes | This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010] |
| GO Molecular Function | DNA-dependent ATPase activity |
|---|---|
| DNA topoisomerase type II (ATP-hydrolyzing) activity | |
| isomerase activity | |
| DNA topoisomerase activity | |
| drug binding | |
| chromatin binding | |
| protein C-terminus binding | |
| enzyme binding | |
| histone deacetylase binding | |
| protein kinase C binding | |
| ubiquitin binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| structure-specific DNA binding | |
| DNA binding, bending | |
| metal ion binding | |
| magnesium ion binding |
| GO Cellular Component | nucleoid |
|---|---|
| nucleoplasm | |
| viral integration complex | |
| nucleolus | |
| nuclear chromosome | |
| synaptonemal complex | |
| centriole | |
| protein complex | |
| DNA topoisomerase complex (ATP-hydrolyzing) | |
| condensed chromosome | |
| nucleus |
| GO Biological Process | resolution of meiotic recombination intermediates |
|---|---|
| chromosome condensation | |
| DNA repair | |
| ATP catabolic process | |
| apoptotic chromosome condensation | |
| brain development | |
| cerebellar Purkinje cell differentiation | |
| cerebellar granule cell differentiation | |
| embryonic cleavage | |
| aging | |
| chromosome segregation | |
| sister chromatid segregation | |
| mitotic DNA integrity checkpoint | |
| mitotic cell cycle | |
| phosphatidylinositol-mediated signaling | |
| positive regulation of apoptotic process | |
| response to drug | |
| response to parathyroid hormone | |
| cellular response to DNA damage stimulus | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of single stranded viral RNA replication via double stranded DNA intermediate | |
| positive regulation of viral genome replication | |
| DNA metabolic process | |
| DNA ligation | |
| DNA replication | |
| mitotic recombination | |
| DNA-dependent DNA replication | |
| DNA topological change |
| Pathway | Proteins Involved in Pathogenesis of Breast Cancer Related to ERBB2/VEGFR/Akt Signaling Pathway |
|---|---|
| Pancreatic Beta-cell Destruction in Diabetes Mellitus Type 1 | |
| Proteins Involved in Pathogenesis of Endometrial Cancer | |
| doxorubicin pharmacodynamics pathway |
| Group | DNA replication |
|---|---|
| DNA repair | |
| Nucleolus organization and biogenesis | |
| resolution of meiotic recombination intermediates | |
| chromosome condensation | |
| DNA repair | |
| ATP catabolic process | |
| DNA-dependent ATPase activity | |
| DNA topoisomerase type II (ATP-hydrolyzing) activity | |
| apoptotic chromosome condensation | |
| brain development | |
| cerebellar Purkinje cell differentiation | |
| cerebellar granule cell differentiation | |
| embryonic cleavage | |
| aging | |
| chromosome segregation | |
| sister chromatid segregation | |
| mitotic DNA integrity checkpoint | |
| mitotic cell cycle | |
| phosphatidylinositol-mediated signaling | |
| positive regulation of apoptotic process | |
| response to drug | |
| response to parathyroid hormone | |
| cellular response to DNA damage stimulus | |
| positive regulation of transcription from RNA polymerase II promoter | |
| positive regulation of single stranded viral RNA replication via double stranded DNA intermediate | |
| positive regulation of viral genome replication | |
| isomerase activity | |
| DNA topoisomerase activity | |
| DNA metabolic process | |
| DNA ligation | |
| DNA replication | |
| mitotic recombination | |
| DNA-dependent DNA replication | |
| DNA topological change | |
| drug binding | |
| chromatin binding | |
| protein C-terminus binding | |
| enzyme binding | |
| histone deacetylase binding | |
| protein kinase C binding | |
| ubiquitin binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| DNA binding | |
| sequence-specific DNA binding | |
| structure-specific DNA binding | |
| DNA binding, bending | |
| metal ion binding | |
| magnesium ion binding | |
| nucleoid | |
| nucleoplasm | |
| viral integration complex | |
| nucleolus | |
| nuclear chromosome | |
| synaptonemal complex | |
| centriole | |
| protein complex | |
| DNA topoisomerase complex (ATP-hydrolyzing) | |
| condensed chromosome | |
| nucleus |
| LocusLink ID | 7153 |
|---|---|
| 21973 | |
| 360243 |
| Cell Localization | Nucleus |
|---|---|
| Cytoplasm | |
| Nucleoplasm |
| GO ID | 0005524 |
|---|---|
| 0003677 | |
| 0008301 | |
| 0003918 | |
| 0008094 | |
| 0003682 | |
| 0008144 | |
| 0019899 | |
| 0042826 | |
| 0000287 | |
| 0008022 | |
| 0046982 | |
| 0042803 | |
| 0005080 | |
| 0043130 | |
| 0006266 | |
| 0006281 | |
| 0006260 | |
| 0006265 | |
| 0006261 | |
| 0030263 | |
| 0006974 | |
| 0007059 | |
| 0040016 | |
| 0000278 | |
| 0006312 | |
| 0048015 | |
| 0043065 | |
| 0045870 | |
| 0045944 | |
| 0045070 | |
| 0000712 | |
| 0000819 | |
| 0009330 | |
| 0005814 | |
| 0000228 | |
| 0009295 | |
| 0005730 | |
| 0005654 | |
| 0005634 | |
| 0043234 | |
| 0000795 | |
| 0019035 | |
| 0003916 | |
| 0016853 | |
| 0046872 | |
| 0000166 | |
| 0043565 | |
| 0043566 | |
| 0006200 | |
| 0006259 | |
| 0030261 | |
| 0044774 | |
| 0000793 | |
| 0007568 | |
| 0007420 | |
| 0021702 | |
| 0021707 | |
| 0042493 | |
| 0071107 |
| Alias | TOP2 |
|---|---|
| TP2A | |
| DNA topoisomerase 2-alpha | |
| DNA gyrase | |
| DNA topoisomerase II, 170 kD | |
| DNA topoisomerase (ATP-hydrolyzing) | |
| DNA topoisomerase II, alpha isozyme | |
| Top-2 | |
| RP23-333D2.5 | |
| DNA Topoisomerase II alpha | |
| topoisomerase (DNA) 2 alpha | |
| topoisomerase (DNA) II alpha (170kD) | |
| 170 kDa topoisomerase (DNA) II alpha | |
| topoisomerase (DNA) II alpha 170kDa | |
| topoisomerase (DNA) II alpha | |
| Top2a | |
| OTTHUMP00000207108 | |
| LOC29390 | |
| OTTMUSP00000006845 |
| Mouse chromosome position | 11 62.91 cM |
|---|
| OMIM ID | 126430 |
|---|
| Rat chromosome position | 10q31 |
|---|
| Hugo ID | 11989 |
|---|
| Human chromosome position | 17q21-q22 |
|---|
| Swiss-Prot Accession | P11388 |
|---|---|
| Q01320 | |
| P41516 | |
| E9PX08 | |
| B2RTS1 | |
| Q71UN1 | |
| Q71UQ5 | |
| Q9HB24 | |
| Q9HB25 | |
| Q9HB26 | |
| Q9UP44 | |
| Q9UQP9 |
| PIR ID | A48536 |
|---|---|
| JN0598 | |
| JS0703 | |
| A40493 |
| Unigene ID | Hs.156346 |
|---|---|
| Mm.4237 | |
| Rn.90996 |
| KEGG ID | hsa:7153 |
|---|---|
| mmu:21973 | |
| rno:360243 |
| Swiss-Prot ID | TOP2A_RAT |
|---|---|
| TOP2A_MOUSE | |
| TOP2A_HUMAN |
| EC Number | 5.99.1.3 |
|---|
| Ensembl ID | ENSG00000131747 |
|---|---|
| ENSP00000411532 | |
| ENST00000423485 | |
| ENSMUSG00000020914 | |
| ENSMUSP00000068896 | |
| ENSMUST00000068031 | |
| ENSRNOG00000032404 | |
| ENSRNOP00000040257 | |
| ENSRNOT00000050725 |
| Homologene ID | 830 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 98790 |
|---|
| RGD ID | 62048 |
|---|
| MedScan ID | 7153 |
|---|