Elsevier Inc. DNA replication pathway DNA transcription pathway Top2b Top2a DOX adducts doxorubicin --+> intrinsic apoptotic pathway doxorubicin --+> doxorubicin response pathway doxorubicin response pathway doxorubicin ---- Top2b doxorubicin ---- Top2a doxorubicin ---| DNA replication pathway doxorubicin ---| DNA transcription pathway doxorubicin doxorubicin ---| cancer cells cancer cells intrinsic apoptotic pathway p53 signaling pathway doxorubicin --+> p53 signaling pathway