| URN | urn:agi-llid:1189 |
|---|---|
| Total Entities | 0 |
| Connectivity | 4289 |
| Name | Abcb1a |
| Description | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| Notes | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. |
| GO Molecular Function | ATPase activity |
|---|---|
| ATPase activity, coupled | |
| ATPase activity, coupled to transmembrane movement of substances | |
| xenobiotic-transporting ATPase activity | |
| hydrolase activity | |
| nucleoside-triphosphatase activity | |
| transporter activity | |
| nucleotide binding | |
| ATP binding |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| apical plasma membrane | |
| Golgi membrane | |
| cell surface | |
| plasma membrane | |
| intercellular canaliculus |
| GO Biological Process | lactation |
|---|---|
| small molecule metabolic process | |
| ATP catabolic process | |
| transmembrane transport | |
| G2-M transition of mitotic cell cycle | |
| drug transmembrane transport | |
| negative regulation of cell death | |
| stem cell proliferation | |
| drug transport | |
| response to drug | |
| response to vitamin D | |
| response to cadmium ion | |
| response to organic cyclic compound | |
| response to hypoxia | |
| transport | |
| circadian rhythm |
| Pathway | Proteins Involved in Pathogenesis of Alzheimer's Disease |
|---|---|
| Proteins Involved in Pathogenesis of Parkinson's Disease | |
| Proteins Involved in Pathogenesis of Inflammatory Bowel Diseases | |
| Common Non-genomic Effects of Thyroid Hormones | |
| Proteins Involved in Pathogenesis of Glioma | |
| Proteins Involved in Pathogenesis of HIV Type 1 Infection | |
| Proteins Involved in Pathogenesis of Cataract | |
| Non-Hereditary Genetic Rearrangements in Neuroblastoma | |
| Proteins Involved in Pathogenesis of Neuroblastoma | |
| Neuroblastoma Overview | |
| Proteins Involved in Pathogenesis of Epilepsy | |
| TLR4/NF-kB/IRF Expression Targets | |
| TNF/CREB Expression Targets | |
| TNF/TP53/ATF Expression Targets | |
| GH1-GHR/STAT Expression Targets | |
| IFNG-IFNR Expression Targets | |
| Prostaglandin F Expression Targets | |
| Glutamate/Gq Expression Targets | |
| Morphine Expression Targets | |
| EDN1 Expression Targets | |
| FGF2/AP-1/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| HGF/STAT Expression Targets | |
| IGF1/STAT Expression Targets | |
| Insulin/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| Insulin/STAT Expression Targets | |
| FGF2/STAT Expression Targets | |
| IL1B/PGE2 Expression Targets | |
| TNF/NF-kB Expression Targets | |
| HGF/AP-1/CREB/ELK-SRF/MYC Expression Targets | |
| IGF1/ELK-SRF/HIF1A/MYC/SREBF Expression Targets | |
| IGF1/MEF/MYOD/MYOG Expression Targets | |
| Insulin/CEBPA/CTNNB/FOXA/FOXO Expression Targets | |
| Insulin/MEF/MYOD Expression Targets | |
| PDGF/AP-1/CREB/CREBBP/MYC Expression Targets | |
| PDGF/STAT Expression Targets | |
| TNF/AP-1 Expression Targets | |
| statin pharmacokinetics pathway | |
| doxorubicin pharmacokinetics pathway |
| Group | Xenobiotic clearance |
|---|---|
| lactation | |
| small molecule metabolic process | |
| ATP catabolic process | |
| ATPase activity | |
| ATPase activity, coupled | |
| ATPase activity, coupled to transmembrane movement of substances | |
| xenobiotic-transporting ATPase activity | |
| transmembrane transport | |
| G2-M transition of mitotic cell cycle | |
| drug transmembrane transport | |
| negative regulation of cell death | |
| stem cell proliferation | |
| drug transport | |
| response to drug | |
| response to vitamin D | |
| response to cadmium ion | |
| response to organic cyclic compound | |
| response to hypoxia | |
| hydrolase activity | |
| nucleoside-triphosphatase activity | |
| transport | |
| transporter activity | |
| circadian rhythm | |
| nucleotide binding | |
| ATP binding | |
| membrane | |
| integral component of membrane | |
| apical plasma membrane | |
| Golgi membrane | |
| cell surface | |
| plasma membrane | |
| intercellular canaliculus | |
| Proteins Considered to Help Prevent Progression of Alzheimer's Disease | |
| Genes with Mutations, Deletions, and Amplifications Associated with Glioma | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 1189 |
|---|---|
| 5243 | |
| 18671 | |
| 170913 |
| Cell Localization | Plasma membrane |
|---|---|
| Cell membrane |
| GO ID | 0005524 |
|---|---|
| 0042626 | |
| 0005215 | |
| 0008559 | |
| 0000086 | |
| 0006855 | |
| 0042493 | |
| 0044281 | |
| 0072089 | |
| 0055085 | |
| 0006810 | |
| 0000139 | |
| 0016324 | |
| 0009986 | |
| 0016021 | |
| 0046581 | |
| 0016020 | |
| 0005886 | |
| 0016887 | |
| 0042623 | |
| 0016787 | |
| 0017111 | |
| 0000166 | |
| 0006200 | |
| 0015893 | |
| 0060548 | |
| 0007623 | |
| 0007595 | |
| 0046686 | |
| 0001666 | |
| 0014070 | |
| 0033280 | |
| 0005515 | |
| 0005624 | |
| 0003674 | |
| 0005575 |
| Alias | CLCS |
|---|---|
| MDR1 | |
| P-GP | |
| PGY1 | |
| ABC20 | |
| CD243 | |
| GP170 | |
| multidrug resistance protein 1 | |
| P-glycoprotein 1 | |
| colchicin sensitivity | |
| doxorubicin resistance | |
| Pgp | |
| Mdr3 | |
| Pgy3 | |
| Abcb4 | |
| Evi32 | |
| Mdr1a | |
| Pgy-3 | |
| mdr-3 | |
| multidrug resistance protein 1A | |
| P glycoprotein 3 | |
| P-glycoprotein 3 | |
| multi-drug resistance 3 | |
| multiple drug resistant 1a | |
| multidrug resistance protein 3 | |
| ecotropic viral integration site 32 | |
| ATP-binding cassette sub-family B member 1A | |
| ATP-binding cassette, subfamily B, member 1A | |
| ATP-binding cassette, sub-family B (MDR/TAP), member 4 | |
| Abcb1 | |
| ATP-binding cassette, sub-family B (MDR/TAP), member 1A | |
| ATP-binding cassette, sub-family B (MDR/TAP), member 1 | |
| ATP-binding cassette, subfamily B (MDR/TAP), member 1A | |
| MDR I | |
| P glycoprotein 1/multiple drug resistance 1 | |
| Multidrug resistance protein I | |
| multidrug resistance 1 | |
| MGC163296 | |
| Mdr1b | |
| P-glycoprotein | |
| PGY I | |
| LOC497782 | |
| MDR-1 P-glycoprotein | |
| P-glycoprotein 1A | |
| LOC360377 | |
| PGP/MDR1 | |
| P-glycoprotein/multidrug resistance 1 | |
| P-MDR I | |
| P-MDR1 | |
| Pgp1 | |
| glycoprotein P-170 | |
| P-170 glycoprotein | |
| P-glycoprotein/multidrug resistance I | |
| ATP-binding cassette transporter B (MDR/TAP) 1A | |
| Abcb I | |
| Abcb1a | |
| Abcb1b | |
| ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1) | |
| ATP-binding cassette sub-family B member 1 | |
| ATP-binding cassette sub-family B member I | |
| ATP-binding cassette transporter B (MDR/TAP) 1 | |
| ATP-binding cassette transporter B (MDR/TAP) 1B | |
| ATP-binding cassette transporter B (MDR/TAP) I | |
| colchicin sensitivity protein | |
| ecotropic viral integrating site 32 | |
| doxorubicin resistance gene | |
| colchicin sensitivity gene | |
| ATP-binding cassette, subfamily B, member 1B | |
| ATP-binding cassette, subfamily B, member 1 | |
| ATP-binding cassette, sub-family B (MDR/TAP), member I | |
| ATP-binding cassette, sub-family B (MDR/TAP), member 1B | |
| doxorubicin resistance protein | |
| P glycoprotein 1 | |
| P-glycoprotein I | |
| multi-drug resistance III | |
| P-MDR Is | |
| P-MDR1s |
| Mouse chromosome position | 5 3.43 cM |
|---|---|
| 5 1.0 cM |
| OMIM ID | 171050 |
|---|---|
| 120080 | |
| 612244 |
| Rat chromosome position | 4q12 |
|---|
| Hugo ID | 40 |
|---|
| Human chromosome position | 7q21.12 |
|---|---|
| 7q21.1 |
| Swiss-Prot Accession | A4D1D2 |
|---|---|
| P08183 | |
| P21447 | |
| Q9CVG4 | |
| Q9JK64 | |
| Q5I1Y5 | |
| A8K294 | |
| Q12755 | |
| Q14812 |
| PIR ID | A34175 |
|---|---|
| A34786 | |
| A34914 |
| Unigene ID | Hs.489033 |
|---|---|
| Hs.737655 | |
| Mm.207354 | |
| Rn.154810 |
| KEGG ID | hsa:5243 |
|---|---|
| mmu:18671 | |
| rno:170913 |
| Swiss-Prot ID | MDR1A_MOUSE |
|---|---|
| MDR1_HUMAN |
| EC Number | 3.6.3.44 |
|---|
| Ensembl ID | ENSG00000085563 |
|---|---|
| ENSP00000265724 | |
| ENST00000265724 | |
| ENSMUSG00000040584 | |
| ENSMUSP00000041204 | |
| ENSMUST00000047753 | |
| ENSRNOG00000008012 | |
| ENSRNOP00000011166 | |
| ENSRNOT00000011166 |
| Homologene ID | 55496 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 97570 |
|---|
| RGD ID | 619951 |
|---|
| MedScan ID | 1189 |
|---|