Protein Abcc2

URN	urn:agi-llid:1244
Total Entities	0
Connectivity	1043
Name	Abcc2
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
Notes	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

GO Molecular Function	ATPase activity
	ATPase activity, coupled to transmembrane movement of substances
	organic anion transmembrane transporter activity
	nucleoside-triphosphatase activity
	transporter activity
	protein domain specific binding
	nucleotide binding
	ATP binding

GO Cellular Component	membrane
	integral component of membrane
	integral component of plasma membrane
	apical plasma membrane
	plasma membrane
	intercellular canaliculus

GO Biological Process	transmembrane transport
	drug transmembrane transport
	cellular chloride ion homeostasis
	thyroid hormone transport
	prostaglandin transport
	organic anion transport
	response to drug
	response to arsenic-containing substance
	response to methotrexate
	response to steroid hormone
	response to estrogen
	response to oxidative stress
	response to heat
	transport

Pathway	paracetamol pharmacokinetics pathway
	statin pharmacokinetics pathway
	doxorubicin pharmacokinetics pathway

Group	Organic anions transport
	ATPase activity
	ATPase activity, coupled to transmembrane movement of substances
	transmembrane transport
	drug transmembrane transport
	organic anion transmembrane transporter activity
	cellular chloride ion homeostasis
	thyroid hormone transport
	prostaglandin transport
	organic anion transport
	response to drug
	response to arsenic-containing substance
	response to methotrexate
	response to steroid hormone
	response to estrogen
	response to oxidative stress
	response to heat
	nucleoside-triphosphatase activity
	transport
	transporter activity
	protein domain specific binding
	nucleotide binding
	ATP binding
	membrane
	integral component of membrane
	integral component of plasma membrane
	apical plasma membrane
	plasma membrane
	intercellular canaliculus
	Secreted proteins
	Biofluids assayable substances

Alias	DJS
	MRP2
	cMRP
	ABC30
	CMOAT
	RP11-114F7.2
	canalicular multispecific organic anion transporter 1
	canalicular multidrug resistance protein
	multidrug resistance-associated protein 2
	ATP-binding cassette sub-family C member 2
	AI173996
	multidrug resistance protein 2
	multidrug resistance associated protein 2
	calicular multispecific organic anion transporter
	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
	OTTHUMP00000020267
	CMOAT I
	CMOAT1
	multidrug resistance protein II
	ATP-binding cassette, subfamily C (CFTR/MRP), member 2
	Multidrug resistance-associated protein II
	rMRP2
	canalicular multispecific organic anion transporter
	multidrug resistance protein-2
	ATP-binding cassette transporter C II
	ATP-binding cassette transporter C 2
	ATP-binding cassette, sub-family C (CFTR/MRP), member II
	Abcc2
	Canalicular multispecific organic anion transporter I
	ATP-binding cassette transporter C (CFTR/MRP) II
	ATP-binding cassette, sub-family C, member 2
	ATP-binding cassette, sub-family C, member II
	ATP-binding cassette transporter C (CFTR/MRP) 2
	KIAA1010
	Multidrug resistance-associated protein 2
	Multidrug resistance-associated protein II
	CMOAT1s
	Canalicular multidrug resistance protein
	expressed sequence AI173996
	CMOAT Is

Mouse chromosome position	19 36.67 cM
	19 43.0 cM

OMIM ID	601107
	237500

Rat chromosome position	1q51

Hugo ID	53

Human chromosome position	10q24

PIR ID	S71839
	S71841

Homologene ID	68052

MGI ID	1352447

RGD ID	2366

MedScan ID	1244
	25303

Primary Cell Localization	Plasma membrane