Protein Abcc3

URN	urn:agi-llid:8714
Total Entities	0
Connectivity	387
Name	Abcc3
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Notes	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GO Molecular Function	ATPase activity
	ATPase activity, coupled to transmembrane movement of substances
	bile acid-exporting ATPase activity
	xenobiotic-transporting ATPase activity
	organic anion transmembrane transporter activity
	drug transmembrane transporter activity
	nucleoside-triphosphatase activity
	transporter activity
	nucleotide binding
	ATP binding

GO Cellular Component	membrane
	integral component of membrane
	integral component of plasma membrane
	basolateral plasma membrane
	plasma membrane

GO Biological Process	small molecule metabolic process
	ATP catabolic process
	bile acid metabolic process
	transmembrane transport
	ion transmembrane transport
	drug transmembrane transport
	lipid transport
	xenobiotic transport
	drug transport
	bile acid and bile salt transport
	canalicular bile acid transport
	response to organic substance
	response to lipopolysaccharide
	response to estradiol
	response to organonitrogen compound
	response to organic cyclic compound
	transport

Pathway	Proteins Involved in Pathogenesis of Glioma
	paracetamol pharmacokinetics pathway
	doxorubicin pharmacokinetics pathway

Group	Organic anions transport
	small molecule metabolic process
	ATP catabolic process
	ATPase activity
	ATPase activity, coupled to transmembrane movement of substances
	bile acid-exporting ATPase activity
	xenobiotic-transporting ATPase activity
	bile acid metabolic process
	transmembrane transport
	ion transmembrane transport
	drug transmembrane transport
	organic anion transmembrane transporter activity
	drug transmembrane transporter activity
	lipid transport
	xenobiotic transport
	drug transport
	bile acid and bile salt transport
	canalicular bile acid transport
	response to organic substance
	response to lipopolysaccharide
	response to estradiol
	response to organonitrogen compound
	response to organic cyclic compound
	nucleoside-triphosphatase activity
	transport
	transporter activity
	nucleotide binding
	ATP binding
	membrane
	integral component of membrane
	integral component of plasma membrane
	basolateral plasma membrane
	plasma membrane
	Secreted proteins
	Biofluids assayable substances

Cell Localization	Plasma membrane
	Membrane

Alias	MLP2
	MRP3
	ABC31
	MOAT-D
	cMOAT2
	EST90757
	canalicular multispecific organic anion transporter 2
	multidrug resistance associated protein
	multidrug resistance-associated protein 3
	ATP-binding cassette sub-family C member 3
	multi-specific organic anion transporter D
	canicular multispecific organic anion transporter
	1700019L09Rik
	RP23-65I14.2
	transporter
	ATP-binding cassette protein C3
	ATP-binding cassette transporter
	MLP-2
	MRP-like protein 2
	organic anion transporter
	multidrug resistance protein 3
	ATP-binding cassette, sub-family C (CFTR/MRP), member 3
	DKFZp686E22157
	Canalicular multispecific organic anion transporter II
	OTTMUSP00000001838
	mrp3b
	ATP-binding cassette, sub-family c, member III
	ATP-binding cassette, subfamily C (CFTR/MRP), member 3
	OTTHUMP00000221670
	OTTHUMP00000221669
	mrp3a
	Multidrug resistance-associated protein III
	ATP-binding cassette, sub-family C, member 3 MRP3B
	1700019L09
	Abcc3
	ATP-binding cassette transporter C (CFTR/MRP) 3
	ATP-binding cassette transporter C (CFTR/MRP) III
	ATP-binding cassette transporter C 3
	ATP-binding cassette transporter C 3 MRP3
	ATP-binding cassette transporter C 3 MRP3A
	ATP-binding cassette transporter C 3 MRP3B
	ATP-binding cassette transporter C III
	ATP-binding cassette, sub-family C (CFTR/MRP), member III
	ATP-binding cassette, sub-family c (cftr\/mrp), member 3
	ATP-binding cassette, sub-family c (cftr\/mrp), member III
	ATP-binding cassette, sub-family c, member 3
	ATP-binding cassette, sub-family C, member 3 MRP3A
	ATP-binding cassette, sub-family C, member 3 MRP3

Mouse chromosome position	11

OMIM ID	604323

Rat chromosome position	10q26

Hugo ID	54

Human chromosome position	17q22

PIR ID	JE0336

Homologene ID	68364

MGI ID	1923658

RGD ID	71101

MedScan ID	8714

Primary Cell Localization	Plasma membrane