| URN | urn:agi-llid:10928 |
|---|---|
| Total Entities | 0 |
| Connectivity | 221 |
| Name | Ralbp1 |
| Description | ralA binding protein 1 |
| Notes | RALBP1 plays a role in receptor-mediated endocytosis and is a downstream effector of the small GTP-binding protein RAL (see RALA; MIM 179550). Small G proteins, such as RAL, have GDP-bound inactive and GTP-bound active forms, which shift from the inactive to the active state through the action of RALGDS (MIM 601619), which in turn is activated by RAS (see HRAS; MIM 190020) (summary by Feig, 2003 [PubMed 12888294]).[supplied by OMIM, Nov 2010] |
| GO Molecular Function | GTPase activator activity |
|---|---|
| Rac GTPase activator activity | |
| ATPase activity | |
| ATPase activity, coupled to movement of substances | |
| Ral GTPase binding | |
| Rac GTPase binding |
| GO Cellular Component | membrane |
|---|---|
| integral component of membrane | |
| spindle pole | |
| intracellular | |
| cytosol | |
| neuron projection |
| GO Biological Process | ATP catabolic process |
|---|---|
| regulation of GTPase activity | |
| positive regulation of Rac GTPase activity | |
| positive regulation of Cdc42 GTPase activity | |
| mitosis | |
| mitotic spindle organization | |
| signal transduction | |
| small GTPase mediated signal transduction | |
| regulation of small GTPase mediated signal transduction | |
| negative regulation of smooth muscle cell proliferation | |
| chemotaxis | |
| transport | |
| endocytosis |
| Pathway | Exocytosis |
|---|---|
| Cancer Overview | |
| doxorubicin pharmacokinetics pathway |
| Group | ATP catabolic process |
|---|---|
| regulation of GTPase activity | |
| GTPase activator activity | |
| Rac GTPase activator activity | |
| positive regulation of Rac GTPase activity | |
| positive regulation of Cdc42 GTPase activity | |
| ATPase activity | |
| ATPase activity, coupled to movement of substances | |
| mitosis | |
| mitotic spindle organization | |
| signal transduction | |
| small GTPase mediated signal transduction | |
| regulation of small GTPase mediated signal transduction | |
| negative regulation of smooth muscle cell proliferation | |
| chemotaxis | |
| transport | |
| endocytosis | |
| Ral GTPase binding | |
| Rac GTPase binding | |
| membrane | |
| integral component of membrane | |
| spindle pole | |
| intracellular | |
| cytosol | |
| neuron projection |
| LocusLink ID | 10928 |
|---|---|
| 19765 | |
| 84014 |
| Cell Localization | Membrane |
|---|---|
| Cytoplasm | |
| Cytosol | |
| Cytoskeleton | |
| Spindle pole |
| GO ID | 0016887 |
|---|---|
| 0043492 | |
| 0005096 | |
| 0030675 | |
| 0048365 | |
| 0017160 | |
| 0006200 | |
| 0006935 | |
| 0043089 | |
| 0043087 | |
| 0051056 | |
| 0007165 | |
| 0007264 | |
| 0006810 | |
| 0005829 | |
| 0016020 | |
| 0006897 | |
| 0007052 | |
| 0048662 | |
| 0032855 | |
| 0005622 | |
| 0043005 | |
| 0007067 | |
| 0016021 | |
| 0000922 |
| Alias | RIP1 |
|---|---|
| RLIP1 | |
| RLIP76 | |
| ralA-binding protein 1 | |
| DNP-SG ATPase | |
| ral-interacting protein 1 | |
| 76 kDa Ral-interacting protein | |
| dinitrophenyl S-glutathione ATPase | |
| cytocentrin | |
| Ral-interacting protein I | |
| RLIP76 proteins | |
| Ral-interactive protein 1 | |
| RALBP1 | |
| RALBP I | |
| ralA-binding protein | |
| ralA binding protein I | |
| Ral-interactive protein I | |
| ralA binding protein 1 | |
| LOC224958 | |
| LOC268968 | |
| MGC108645 | |
| OTTHUMP00000162351 | |
| ralA binding protein |
| Mouse chromosome position | 17 35.26 cM |
|---|
| OMIM ID | 605801 |
|---|
| Rat chromosome position | 9q37 |
|---|
| Hugo ID | 9841 |
|---|
| Human chromosome position | 18p11.3 |
|---|
| Swiss-Prot Accession | Q15311 |
|---|---|
| Q62172 | |
| Q62796 | |
| O55195 | |
| D3DUI0 | |
| Q6NXH5 | |
| Q9CRE5 |
| PIR ID | A57467 |
|---|---|
| F59435 |
| Unigene ID | Hs.528993 |
|---|---|
| Mm.17009 | |
| Mm.486223 | |
| Rn.7107 |
| KEGG ID | hsa:10928 |
|---|---|
| mmu:19765 | |
| rno:84014 |
| Swiss-Prot ID | RBP1_RAT |
|---|---|
| RBP1_HUMAN | |
| RBP1_MOUSE |
| Ensembl ID | ENSG00000017797 |
|---|---|
| ENSP00000372924 | |
| ENST00000383432 | |
| ENSP00000019317 | |
| ENST00000019317 | |
| ENSMUSG00000024096 | |
| ENSMUSP00000024905 | |
| ENSMUST00000024905 | |
| ENSMUSP00000129448 | |
| ENSMUST00000166543 | |
| ENSRNOG00000013461 | |
| ENSRNOP00000033120 | |
| ENSRNOT00000035606 |
| Homologene ID | 4940 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 108466 |
|---|
| RGD ID | 621134 |
|---|
| MedScan ID | 10928 |
|---|