| URN | urn:agi-llid:7498 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1763 |
| Name | Xdh |
| Description | xanthine dehydrogenase |
| Notes | Xanthine dehydrogenase belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| oxidoreductase activity, acting on CH-OH group of donors | |
| UDP-N-acetylmuramate dehydrogenase activity | |
| xanthine dehydrogenase activity | |
| xanthine oxidase activity | |
| catalytic activity | |
| electron carrier activity | |
| protein homodimerization activity | |
| flavin adenine dinucleotide binding | |
| molybdopterin cofactor binding | |
| metal ion binding | |
| molybdenum ion binding | |
| iron ion binding | |
| iron-sulfur cluster binding | |
| 2 iron, 2 sulfur cluster binding |
| GO Cellular Component | extracellular region |
|---|---|
| cytoplasm | |
| cytosol | |
| peroxisome | |
| extracellular space |
| GO Biological Process | lactation |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| positive regulation of p38MAPK cascade | |
| xanthine catabolic process | |
| purine nucleotide catabolic process | |
| nucleobase-containing small molecule metabolic process | |
| purine nucleobase metabolic process | |
| bone resorption | |
| negative regulation of vasculogenesis | |
| regulation of epithelial cell differentiation | |
| negative regulation of endothelial cell differentiation | |
| negative regulation of protein kinase B signaling | |
| negative regulation of vascular endothelial growth factor signaling pathway | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| negative regulation of endothelial cell proliferation | |
| response to aluminum ion | |
| positive regulation of reactive oxygen species metabolic process | |
| negative regulation of protein phosphorylation | |
| negative regulation of gene expression |
| Pathway | Neurotoxin-Induced Parkinson's Disease |
|---|---|
| APP and Glutamate Signaling-Related Neuronal Dysfunction in Alzheimer's Disease | |
| Endothelial Cell Dysfunction in Pulmonary Arterial Hypertension | |
| Smooth Muscle Cell Dysfunction in Pulmonary Arterial Hypertension | |
| Proteins Involved in Pathogenesis of Pulmonary Hypertension | |
| Proteins Involved in Pathogenesis of Gout | |
| Increased Uric Acid Synthesis in Gout | |
| Glutamate-Mediated Excitotoxicity in Amyotrophic Lateral Sclerosis | |
| Proteins Involved in Pathogenesis of Myocardial Ischemia | |
| Glutamate-Mediated Excitotoxicity | |
| Ethanol-Induced Hepatotoxicity | |
| PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets | |
| PRL-GHR/STAT Expression Targets | |
| PRL-PRLR Expression Targets | |
| doxorubicin pharmacokinetics pathway |
| Group | Purine metabolism |
|---|---|
| lactation | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| positive regulation of p38MAPK cascade | |
| xanthine catabolic process | |
| purine nucleotide catabolic process | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on CH-OH group of donors | |
| UDP-N-acetylmuramate dehydrogenase activity | |
| xanthine dehydrogenase activity | |
| xanthine oxidase activity | |
| nucleobase-containing small molecule metabolic process | |
| purine nucleobase metabolic process | |
| bone resorption | |
| negative regulation of vasculogenesis | |
| regulation of epithelial cell differentiation | |
| negative regulation of endothelial cell differentiation | |
| negative regulation of protein kinase B signaling | |
| negative regulation of vascular endothelial growth factor signaling pathway | |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | |
| negative regulation of endothelial cell proliferation | |
| response to aluminum ion | |
| positive regulation of reactive oxygen species metabolic process | |
| negative regulation of protein phosphorylation | |
| negative regulation of gene expression | |
| catalytic activity | |
| electron carrier activity | |
| protein homodimerization activity | |
| flavin adenine dinucleotide binding | |
| molybdopterin cofactor binding | |
| metal ion binding | |
| molybdenum ion binding | |
| iron ion binding | |
| iron-sulfur cluster binding | |
| 2 iron, 2 sulfur cluster binding | |
| extracellular region | |
| cytoplasm | |
| cytosol | |
| peroxisome | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| LocusLink ID | 7498 |
|---|---|
| 22436 | |
| 497811 |
| Cell Localization | Cytoplasm |
|---|---|
| Peroxisome | |
| Secreted |
| GO ID | 0051537 |
|---|---|
| 0008762 | |
| 0009055 | |
| 0050660 | |
| 0005506 | |
| 0043546 | |
| 0042803 | |
| 0004854 | |
| 0004855 | |
| 0006919 | |
| 0007595 | |
| 0045602 | |
| 0001937 | |
| 0010629 | |
| 0051898 | |
| 0001933 | |
| 1900747 | |
| 2001213 | |
| 0055086 | |
| 1900745 | |
| 2000379 | |
| 0006144 | |
| 0006195 | |
| 0044281 | |
| 0009115 | |
| 0005829 | |
| 0005576 | |
| 0005777 | |
| 0003824 | |
| 0051536 | |
| 0046872 | |
| 0030151 | |
| 0016491 | |
| 0016614 | |
| 0045453 | |
| 0055114 | |
| 0030856 | |
| 0010044 | |
| 0005737 | |
| 0005615 |
| Alias | XO |
|---|---|
| XOR | |
| xanthine dehydrogenase/oxidase | |
| xanthine oxidase | |
| xanthene dehydrogenase | |
| xanthine oxidoreductase | |
| Xox1 | |
| Xox-1 | |
| XDHA | |
| Xox I | |
| Xdh | |
| xanthine dehydrogenase | |
| OTTHUMP00000125231 | |
| NAD-xanthine dehydrogenase | |
| LOC360409 | |
| xanthine-NAD oxidoreductase |
| Mouse chromosome position | 17 45.25 cM |
|---|
| OMIM ID | 607633 |
|---|---|
| 278300 |
| Rat chromosome position | 6q13 |
|---|
| Hugo ID | 12805 |
|---|
| Human chromosome position | 2p23.1 |
|---|
| Swiss-Prot Accession | P47989 |
|---|---|
| Q00519 | |
| Q3UMS6 | |
| P22985 | |
| Q63157 | |
| Q16681 | |
| Q16712 | |
| Q4PJ16 | |
| E9QLM9 |
| PIR ID | S66573 |
|---|---|
| I48374 |
| Unigene ID | Hs.250 |
|---|---|
| Mm.11223 | |
| Rn.202951 |
| KEGG ID | hsa:7498 |
|---|---|
| mmu:22436 | |
| rno:497811 |
| Swiss-Prot ID | XDH_RAT |
|---|---|
| XDH_HUMAN | |
| XDH_MOUSE |
| EC Number | 1.17.3.2 |
|---|---|
| 1.17.1.4 |
| Ensembl ID | ENSG00000158125 |
|---|---|
| ENSP00000368727 | |
| ENST00000379416 | |
| ENSMUSG00000024066 | |
| ENSMUSP00000024866 | |
| ENSMUST00000024866 | |
| ENSRNOG00000007081 | |
| ENSRNOP00000009634 | |
| ENSRNOT00000009634 |
| Homologene ID | 324 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 98973 |
|---|
| RGD ID | 62043 |
|---|
| MedScan ID | 7498 |
|---|