| URN | urn:agi-llid:874 |
|---|---|
| Total Entities | 0 |
| Connectivity | 49 |
| Name | Cbr3 |
| Description | carbonyl reductase 3 |
| Notes | Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| carbonyl reductase (NADPH) activity | |
| 3-keto sterol reductase activity | |
| NADPH binding |
| GO Cellular Component | nucleolus |
|---|---|
| cytoplasm | |
| cytosol | |
| nucleus |
| GO Biological Process | metabolic process |
|---|---|
| oxidation-reduction process | |
| phylloquinone catabolic process |
| Pathway | doxorubicin pharmacokinetics pathway |
|---|
| Group | Prostaglandins, Thromboxane synthesis |
|---|---|
| metabolic process | |
| oxidation-reduction process | |
| phylloquinone catabolic process | |
| oxidoreductase activity | |
| carbonyl reductase (NADPH) activity | |
| 3-keto sterol reductase activity | |
| NADPH binding | |
| nucleolus | |
| cytoplasm | |
| cytosol | |
| nucleus |
| LocusLink ID | 874 |
|---|---|
| 109857 | |
| 304078 |
| Cell Localization | Plasma membrane |
|---|---|
| Cytoplasm |
| GO ID | 0000253 |
|---|---|
| 0070402 | |
| 0004090 | |
| 0042376 | |
| 0005737 | |
| 0005829 | |
| 0005730 | |
| 0005634 | |
| 0016491 | |
| 0008152 | |
| 0055114 |
| Alias | hCBR3 |
|---|---|
| SDR21C2 | |
| HEL-S-25 | |
| carbonyl reductase [NADPH] 3 | |
| carbonyl reductase (NADPH) 3 | |
| epididymis secretory protein Li 25 | |
| NADPH-dependent carbonyl reductase 3 | |
| short chain dehydrogenase/reductase family 21C, member 2 | |
| C81353 | |
| 1110001J05Rik | |
| OTTMUSP00000021475 | |
| NAD(P)H-dependent carbonyl reductase 3 | |
| 1110001J05 | |
| carbonyl reductase (NAD(P)H) 3 | |
| carbonyl reductase (NAD(P)H) III | |
| carbonyl reductase (NADP(H)) 3 | |
| carbonyl reductase (NADP(H)) III | |
| carbonyl reductase (NADPH) III | |
| carbonyl reductase 3 | |
| carbonyl reductase III | |
| CBR3 | |
| MGC99956 | |
| NAD(P)H-dependent carbonyl reductase III | |
| NADP(H)-dependent carbonyl reductase 3 | |
| NADP(H)-dependent carbonyl reductase III | |
| NADPH-dependent carbonyl reductase III | |
| RIKEN cDNA 1110001J05 gene |
| Mouse chromosome position | 16 54.58 cM |
|---|
| OMIM ID | 603608 |
|---|
| Rat chromosome position | 11q11 |
|---|
| Hugo ID | 1549 |
|---|
| Human chromosome position | 21q22.2 |
|---|
| Swiss-Prot Accession | O75828 |
|---|---|
| Q8K354 | |
| B2GV72 | |
| Q6FHP2 |
| Unigene ID | Hs.154510 |
|---|---|
| Mm.4512 | |
| Rn.8624 |
| KEGG ID | hsa:874 |
|---|---|
| mmu:109857 | |
| rno:304078 |
| Swiss-Prot ID | CBR3_MOUSE |
|---|---|
| CBR3_HUMAN |
| EC Number | 1.1.1.184 |
|---|
| Ensembl ID | ENSG00000159231 |
|---|---|
| ENSP00000290354 | |
| ENST00000290354 | |
| ENSMUSG00000022947 | |
| ENSMUSP00000047712 | |
| ENSMUST00000039620 | |
| ENSRNOG00000001701 | |
| ENSRNOP00000002310 | |
| ENSRNOT00000002310 |
| Homologene ID | 20332 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1309992 |
|---|
| RGD ID | 1309728 |
|---|
| MedScan ID | 874 |
|---|