| URN | urn:agi-llid:873 |
|---|---|
| Total Entities | 0 |
| Connectivity | 261 |
| Name | Cbr1 |
| Description | carbonyl reductase 1 |
| Notes | Carbonyl reductase is one of several monomeric, NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds. This enzyme is widely distributed in human tissues. Another carbonyl reductase gene, CRB3, lies close to this gene on chromosome 21q. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | |
| 15-hydroxyprostaglandin dehydrogenase (NADP+) activity | |
| prostaglandin-E2 9-reductase activity | |
| carbonyl reductase (NADPH) activity |
| GO Cellular Component | plasma membrane |
|---|---|
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| microvillus |
| GO Biological Process | metabolic process |
|---|---|
| ovulation from ovarian follicle | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| cyclooxygenase pathway | |
| phylloquinone catabolic process | |
| arachidonic acid metabolic process | |
| vitamin K metabolic process | |
| response to lipopolysaccharide | |
| response to testosterone | |
| response to gonadotropin | |
| drug metabolic process | |
| peptidyl-lysine modification |
| Pathway | prostanoid biosynthetic pathway |
|---|---|
| doxorubicin pharmacokinetics pathway |
| Group | Prostaglandins, Thromboxane synthesis |
|---|---|
| metabolic process | |
| ovulation from ovarian follicle | |
| small molecule metabolic process | |
| oxidation-reduction process | |
| cyclooxygenase pathway | |
| phylloquinone catabolic process | |
| oxidoreductase activity | |
| oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | |
| 15-hydroxyprostaglandin dehydrogenase (NADP+) activity | |
| prostaglandin-E2 9-reductase activity | |
| carbonyl reductase (NADPH) activity | |
| arachidonic acid metabolic process | |
| vitamin K metabolic process | |
| response to lipopolysaccharide | |
| response to testosterone | |
| response to gonadotropin | |
| drug metabolic process | |
| peptidyl-lysine modification | |
| plasma membrane | |
| cytoplasm | |
| cytosol | |
| intracellular membrane-bounded organelle | |
| nucleus | |
| microvillus | |
| Secreted proteins |
| LocusLink ID | 873 |
|---|---|
| 12408 | |
| 29224 | |
| 100360507 |
| Cell Localization | Plasma membrane |
|---|---|
| Cytoplasm |
| GO ID | 0047021 |
|---|---|
| 0004090 | |
| 0016655 | |
| 0050221 | |
| 0019369 | |
| 0019371 | |
| 0017144 | |
| 0055114 | |
| 0044281 | |
| 0042373 | |
| 0005829 | |
| 0016491 | |
| 0008152 | |
| 0005737 | |
| 0043231 | |
| 0005902 | |
| 0005634 | |
| 0005886 | |
| 0001542 | |
| 0018205 | |
| 0042376 | |
| 0034698 | |
| 0032496 | |
| 0033574 | |
| 0000166 |
| Alias | CBR |
|---|---|
| hCBR1 | |
| SDR21C1 | |
| carbonyl reductase [NADPH] 1 | |
| carbonyl reductase (NADPH) 1 | |
| prostaglandin 9-ketoreductase | |
| prostaglandin-E(2) 9-reductase | |
| NADPH-dependent carbonyl reductase 1 | |
| 15-hydroxyprostaglandin dehydrogenase | |
| short chain dehydrogenase/reductase family 21C, member 1 | |
| CR | |
| AW261796 | |
| Carbonyl reductase [NADPH] 1 (NADPH-dependent carbonyl reductase 1) | |
| Cbr 1 | |
| 20-beta-hydroxysteroid dehydrogenase | |
| inducible carbonyl reductase-like | |
| CRN | |
| NADP-specific 15-hydroxyprostaglandin dehydrogenase | |
| 15-hydroxyprostaglandin dehydrogenases | |
| 9-ketoprostaglandin reductase | |
| 9-keto-prostaglandin E2 reductase | |
| nonspecific NADP(H)-dependent carbonyl reductase | |
| nonspecific NAD(P)H-dependent carbonyl reductase | |
| NADP-dependent 15-hydroxyprostaglandin dehydrogenase | |
| NADP-specific 15-hydroxyprostaglandin dehydrogenases | |
| carbonyl reductase (NAD(P)H) | |
| NADP-linked 15-hydroxyprostaglandin dehydrogenases | |
| NADP-linked 15-hydroxyprostaglandin dehydrogenase | |
| NADPH-dependent carbonyl reductase I | |
| NADPH2-dependent carbonyl reductase | |
| carbonyl reductase (NAD(P)H) I | |
| nonspecific NADPH-dependent carbonyl reductase | |
| NAD(P)H-dependent carbonyl reductase 1 | |
| carbonyl reductase (NADP(H)) | |
| carbonyl reductase (NADP(H)) 1 | |
| carbonyl reductase (NADP(H)) I | |
| carbonyl reductase (NADPH) | |
| carbonyl reductase (NADPH) I | |
| carbonyl reductase 1 | |
| ALR3 | |
| carbonyl reductase I | |
| CBR1 | |
| LOC224441 | |
| MGC124927 | |
| NAD(P)H2-dependent carbonyl reductase | |
| carbonyl reductase (NAD(P)H) 1 | |
| NADP(H)-dependent carbonyl reductase I | |
| carbonyl reductase 2 (Cricetulus griseus) | |
| prostaglandin E 9-ketoreductase | |
| type II 15-hydroxyprostaglandin dehydrogenases | |
| type II 15-hydroxyprostaglandin dehydrogenase | |
| reductase, 15-hydroxy-9-oxoprostaglandin | |
| NADP-dependent 15-hydroxyprostaglandin dehydrogenases | |
| prostaglandin E2-9-oxoreductase | |
| Carbonyl reductase [NADP(H)] 1 (NADP(H)-dependent carbonyl reductase 1) | |
| PGE-9-ketoreductase | |
| PGE2-9-OR | |
| PGE2-9-ketoreductase | |
| PGE2 9-oxoreductase | |
| OTTMUSP00000021476 | |
| prostaglandin E2-9-oxoreductases | |
| LOC100360507 | |
| NADP(H)-dependent carbonyl reductase 1 | |
| NADP(H)2-dependent carbonyl reductase | |
| NAD(P)H-dependent carbonyl reductase I | |
| 15-hydroxyprostaglandin dehydrogenase (NADP) | |
| 15-hydroxyprostaglandin dehydrogenase (NADP+) | |
| xenobiotic ketone reductase | |
| LOC100912203 | |
| Carbonyl reductase [NAD(P)H] 1 (NAD(P)H-dependent carbonyl reductase 1) | |
| Carbonyl reductase (NADPH) 1 (NADPH-dependent carbonyl reductase 1) | |
| Carbonyl reductase (NADP(H)) 1 (NADP(H)-dependent carbonyl reductase 1) | |
| Carbonyl reductase (NAD(P)H) 1 (NAD(P)H-dependent carbonyl reductase 1) |
| Mouse chromosome position | 16 54.53 cM |
|---|---|
| 16 67.0 cM |
| OMIM ID | 114830 |
|---|
| Rat chromosome position | 11q11 |
|---|---|
| 11 |
| Hugo ID | 1548 |
|---|
| Human chromosome position | 21q22.13 |
|---|
| Swiss-Prot Accession | P16152 |
|---|---|
| B4DFK7 | |
| B2RXY7 | |
| P48758 | |
| P47727 | |
| O08558 | |
| Q3KR58 | |
| Q91X28 | |
| B2RBZ7 | |
| Q3LHW8 |
| PIR ID | S68982 |
|---|---|
| A61271 |
| Unigene ID | Hs.88778 |
|---|---|
| Mm.26940 | |
| Rn.3425 |
| KEGG ID | hsa:873 |
|---|---|
| mmu:12408 | |
| rno:29224 | |
| rno:100360507 | |
| rno:100912203 |
| Swiss-Prot ID | CBR1_RAT |
|---|---|
| CBR1_MOUSE | |
| CBR1_HUMAN |
| EC Number | 1.1.1.197 |
|---|---|
| 1.1.1.184 | |
| 1.1.1.189 |
| Ensembl ID | ENSG00000159228 |
|---|---|
| ENSP00000290349 | |
| ENST00000290349 | |
| ENSP00000434613 | |
| ENST00000530908 | |
| ENSMUSG00000051483 | |
| ENSMUSP00000049394 | |
| ENSMUST00000039659 | |
| ENSRNOG00000049693 | |
| ENSRNOP00000051107 | |
| ENSRNOT00000041838 | |
| ENSRNOG00000047848 | |
| ENSRNOP00000043385 | |
| ENSRNOT00000042283 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 88284 |
|---|
| RGD ID | 2286 |
|---|
| MedScan ID | 873 |
|---|---|
| 649801 |
| Primary Cell Localization | Plasma membrane |
|---|
| IPI ID | IPI00295386 |
|---|---|
| IPI00314191 | |
| IPI00331856 |