| URN | urn:agi-llid:10327 |
|---|---|
| Total Entities | 0 |
| Connectivity | 57 |
| Name | Akr1a1 |
| Description | aldo-keto reductase family 1, member A1 (aldehyde reductase) |
| Notes | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| L-glucuronate reductase activity | |
| alcohol dehydrogenase (NADP+) activity | |
| alditol:NADP+ 1-oxidoreductase activity | |
| electron carrier activity |
| GO Cellular Component | apical plasma membrane |
|---|---|
| cytosol |
| GO Biological Process | cellular aldehyde metabolic process |
|---|---|
| oxidation-reduction process | |
| L-ascorbic acid biosynthetic process | |
| aldehyde catabolic process | |
| D-glucuronate catabolic process | |
| glucose metabolic process |
| Pathway | prostanoid biosynthetic pathway |
|---|---|
| doxorubicin pharmacokinetics pathway |
| Group | Glucose metabolism |
|---|---|
| cellular aldehyde metabolic process | |
| oxidation-reduction process | |
| L-ascorbic acid biosynthetic process | |
| aldehyde catabolic process | |
| D-glucuronate catabolic process | |
| glucose metabolic process | |
| oxidoreductase activity | |
| L-glucuronate reductase activity | |
| alcohol dehydrogenase (NADP+) activity | |
| alditol:NADP+ 1-oxidoreductase activity | |
| electron carrier activity | |
| apical plasma membrane | |
| cytosol |
| LocusLink ID | 10327 |
|---|---|
| 58810 | |
| 78959 |
| Cell Localization | Cytoplasm |
|---|
| GO ID | 0047939 |
|---|---|
| 0004032 | |
| 0009055 | |
| 0042840 | |
| 0019853 | |
| 0046185 | |
| 0006081 | |
| 0006006 | |
| 0016324 | |
| 0005829 | |
| 0008106 | |
| 0016491 | |
| 0055114 |
| Alias | ALR |
|---|---|
| ARM | |
| DD3 | |
| ALDR1 | |
| HEL-S-6 | |
| RP4-697E16.2 | |
| alcohol dehydrogenase [NADP(+)] | |
| HEL-S-165mP | |
| aldehyde reductase | |
| alcohol dehydrogenase | |
| dihydrodiol dehydrogenase 3 | |
| epididymis secretory protein Li 6 | |
| aldo-keto reductase family 1 member A1 | |
| epididymis secretory sperm binding protein Li 165mP | |
| Akr1a4 | |
| 2610201A18Rik | |
| RP23-177C18.1 | |
| aldo-keto reductase family 1, member A4 (aldehyde reductase) | |
| 3-DG-reducing enzyme | |
| MGC1380 | |
| OTTHUMP00000009240 | |
| OTTHUMP00000009241 | |
| OTTMUSP00000009953 | |
| RIKEN cDNA 2610201A18 gene | |
| MGC12529 | |
| 2610201A18 | |
| 2610201A18Rik(2) | |
| Akr1a I | |
| Akr1a1 | |
| aldehyde reductase (Cricetulus griseus) | |
| aldo-keto reductase family 1, member A1 | |
| aldo-keto reductase family 1, member A1 (aldehyde reductase) | |
| aldo-keto reductase family 1, member a4 |
| Mouse chromosome position | 4 |
|---|
| OMIM ID | 103830 |
|---|
| Rat chromosome position | 5q36 |
|---|
| Hugo ID | 380 |
|---|
| Human chromosome position | 1p33-p32 |
|---|
| Swiss-Prot Accession | P14550 |
|---|---|
| Q540D7 | |
| Q80XJ7 | |
| Q9JII6 | |
| P51635 | |
| A8KAL8 | |
| D3DQ04 | |
| Q6IAZ4 | |
| Q9CQI5 | |
| Q9CQT8 | |
| Q9CT53 | |
| Q9D012 | |
| Q9D016 | |
| Q9D0I7 | |
| Q9D0P3 |
| PIR ID | A33851 |
|---|---|
| JN0629 |
| Unigene ID | Hs.474584 |
|---|---|
| Hs.721160 | |
| Mm.30085 | |
| Mm.489607 | |
| Rn.835 |
| KEGG ID | hsa:10327 |
|---|---|
| mmu:58810 | |
| rno:78959 |
| Swiss-Prot ID | AK1A1_HUMAN |
|---|---|
| AK1A1_RAT | |
| AK1A1_MOUSE |
| EC Number | 1.1.1.2 |
|---|
| Ensembl ID | ENSG00000117448 |
|---|---|
| ENSP00000361140 | |
| ENST00000372070 | |
| ENSP00000312606 | |
| ENST00000351829 | |
| ENSMUSG00000028692 | |
| ENSMUSP00000030455 | |
| ENSMUST00000030455 | |
| ENSRNOG00000016727 | |
| ENSRNOP00000023072 | |
| ENSRNOT00000023072 |
| Homologene ID | 74565 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 1929955 |
|---|
| RGD ID | 68346 |
|---|
| MedScan ID | 10327 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00466128 |
|---|---|
| IPI00220271 | |
| IPI00230859 |