| URN | urn:agi-llid:1728 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1362 |
| Name | Nqo1 |
| Description | NAD(P)H dehydrogenase, quinone 1 |
| Notes | This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| GO Molecular Function | oxidoreductase activity |
|---|---|
| NAD(P)H dehydrogenase (quinone) activity | |
| cytochrome-b5 reductase activity, acting on NAD(P)H | |
| superoxide dismutase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol | |
| neuronal cell body |
| GO Biological Process | small molecule metabolic process |
|---|---|
| oxidation-reduction process | |
| regulation of cellular amino acid metabolic process | |
| aging | |
| synaptic transmission, cholinergic | |
| positive regulation of neuron apoptotic process | |
| response to toxic substance | |
| response to nutrient | |
| response to estradiol | |
| response to ethanol | |
| xenobiotic metabolic process | |
| response to organic cyclic compound | |
| response to oxidative stress | |
| negative regulation of catalytic activity | |
| cellular nitrogen compound metabolic process | |
| superoxide metabolic process | |
| nitric oxide biosynthetic process |
| Pathway | Neurotoxin-Induced Parkinson's Disease |
|---|---|
| Oxidative Stress in Amyotrophic Lateral Sclerosis | |
| doxorubicin pharmacokinetics pathway |
| Group | Cholesterol/isoprenoid metabolism |
|---|---|
| small molecule metabolic process | |
| oxidation-reduction process | |
| oxidoreductase activity | |
| NAD(P)H dehydrogenase (quinone) activity | |
| cytochrome-b5 reductase activity, acting on NAD(P)H | |
| superoxide dismutase activity | |
| regulation of cellular amino acid metabolic process | |
| aging | |
| synaptic transmission, cholinergic | |
| positive regulation of neuron apoptotic process | |
| response to toxic substance | |
| response to nutrient | |
| response to estradiol | |
| response to ethanol | |
| xenobiotic metabolic process | |
| response to organic cyclic compound | |
| response to oxidative stress | |
| negative regulation of catalytic activity | |
| cellular nitrogen compound metabolic process | |
| superoxide metabolic process | |
| nitric oxide biosynthetic process | |
| cytoplasm | |
| cytosol | |
| neuronal cell body | |
| Secreted proteins |
| LocusLink ID | 1728 |
|---|---|
| 18104 | |
| 24314 |
| Cell Localization | Endoplasmic reticulum |
|---|---|
| Cytoplasm |
| GO ID | 0003955 |
|---|---|
| 0004128 | |
| 0004784 | |
| 0007568 | |
| 0034641 | |
| 0043086 | |
| 0006809 | |
| 0043525 | |
| 0006521 | |
| 0032355 | |
| 0045471 | |
| 0007584 | |
| 0006979 | |
| 0009636 | |
| 0044281 | |
| 0006801 | |
| 0007271 | |
| 0006805 | |
| 0005737 | |
| 0005829 | |
| 0043025 | |
| 0016491 | |
| 0055114 | |
| 0014070 |
| Alias | DTD |
|---|---|
| QR1 | |
| DHQU | |
| DIA4 | |
| NMOR1 | |
| NMORI | |
| NAD(P)H dehydrogenase [quinone] 1 | |
| azoreductase | |
| diaphorase-4 | |
| DT-diaphorase | |
| dioxin-inducible 1 | |
| menadione reductase | |
| quinone reductase 1 | |
| phylloquinone reductase | |
| NAD(P)H:quinone oxireductase | |
| NAD(P)H:quinone oxidoreductase 1 | |
| NAD(P)H:menadione oxidoreductase 1 | |
| NAD(P)H:Quinone acceptor oxidoreductase type 1 | |
| diaphorase (NADH/NADPH) (cytochrome b-5 reductase) | |
| Ox1 | |
| Nmo1 | |
| Ox-1 | |
| Nmo-1 | |
| AV001255 | |
| diaphorase 4 (NADH/NADPH) | |
| NAD(P)H dehydrogenase (quinone) | |
| NAD(P)H menadione oxidoreductase 1, dioxin inducible | |
| Diaphorase (NADH/NADPH) | |
| NAD(P)H:menadione oxidoreductase | |
| NADPH:menadione oxidoreductase 1, dioxin-inducible 1 | |
| NADP(H) menadione oxidoreductase 1, dioxin inducible | |
| NADPH dehydrogenase, quinone 1 | |
| NADPH:menadione oxidoreductase | |
| NADPH menadione oxidoreductase 1, dioxin inducible | |
| NADPH dehydrogenase, quinone I | |
| NADPH:menadione oxidoreductase 1 | |
| NADPH dehydrogenase (quinone) | |
| NADP(H):quinone oxireductase | |
| NADP(H):quinone acceptor oxidoreductase type 1 | |
| NADP(H):menadione oxidoreductase 1, dioxin-inducible 1 | |
| NADP(H):menadione oxidoreductase | |
| NADPH:quinone acceptor oxidoreductase type 1 | |
| methyl red azoreductase | |
| NADP(H):menadione oxidoreductase 1 | |
| methyl red reductase | |
| azobenzene reductase | |
| NADP(H) dehydrogenase, quinone I | |
| azo reduction | |
| NADPH:quinone oxireductase | |
| OTTMUSP00000026299 | |
| NQO1 | |
| NQO I | |
| NMOR I | |
| azo reductase | |
| diaphorase (NADH/NADP(H)) (cytochrome b-5 reductase) | |
| diaphorase (NADH/NAD(P)H) | |
| NADP(H) dehydrogenase, quinone 1 | |
| diaphorase (NADH/NADP(H)) | |
| diaphorase 4 (NADH/NAD(P)H) | |
| diaphorase 4 (NADH/NADP(H)) | |
| diaphorase IV | |
| NAD(P)H:menadione oxidoreductase 1, dioxin-inducible 1 | |
| diaphorase (NADH/NAD(P)H) (cytochrome b-5 reductase) | |
| NADP(H) dehydrogenase (quinone) | |
| NAD(P)H dehydrogenase, quinone I | |
| NAD(P)H dehydrogenase, quinone 1 | |
| MGC93075 |
| Mouse chromosome position | 8 54.08 cM |
|---|
| OMIM ID | 125860 |
|---|
| Rat chromosome position | 19q12 |
|---|
| Hugo ID | 2874 |
|---|
| Human chromosome position | 16q22.1 |
|---|
| Swiss-Prot Accession | P15559 |
|---|---|
| B4DLR8 | |
| Q542Y0 | |
| Q64669 | |
| P05982 | |
| Q63478 | |
| B2R5Y9 | |
| B4DNM7 | |
| B7ZAD1 | |
| Q86UK1 |
| PIR ID | A57691 |
|---|---|
| A34162 | |
| A41135 |
| Unigene ID | Hs.406515 |
|---|---|
| Mm.252 | |
| Rn.11234 |
| KEGG ID | hsa:1728 |
|---|---|
| mmu:18104 | |
| rno:24314 |
| Swiss-Prot ID | NQO1_MOUSE |
|---|---|
| NQO1_RAT | |
| NQO1_HUMAN |
| EC Number | 1.6.5.2 |
|---|
| Ensembl ID | ENSG00000181019 |
|---|---|
| ENSP00000319788 | |
| ENST00000320623 | |
| ENSP00000368335 | |
| ENST00000379047 | |
| ENSMUSG00000003849 | |
| ENSMUSP00000003947 | |
| ENSMUST00000003947 | |
| ENSRNOG00000012772 | |
| ENSRNOP00000017175 | |
| ENSRNOT00000017174 |
| Homologene ID | 695 |
|---|
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| MGI ID | 103187 |
|---|
| RGD ID | 2503 |
|---|
| MedScan ID | 1728 |
|---|