Elsevier Inc. doxorubicin ---> doxorubicinol Ralbp1 Abcg2 Abcc3 Abcb1a Abcc2 Nos3 Nqo1 Xdh Cbr3 Cbr1 Akr1a1 Akr1c3 Slc22a16 ROS generation deglycosidation further processing doxorubicinol ---> elimination doxorubicin aglycone ---> elimination elimination doxorubicin one-electron reduction doxorubicin ---> doxorubicin semiquinone two-electron reduction Slc22a16 ---> doxorubicin doxorubicin semiquinone ---> elimination doxorubicin ---> elimination doxorubicin aglycone doxorubicinol doxorubicin semiquinone doxorubicin ---> doxorubicin aglycone