Protein Abcc4

URN	urn:agi-llid:10257
Total Entities	0
Connectivity	333
Name	Abcc4
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 4
Notes	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions. Alternative splicing results in multiple splice variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Ariadne Ontology	Organic anions transport
	Secreted proteins
	Biofluids assayable substances

GO Molecular Function	nucleotide binding
	ATP binding
	15-hydroxyprostaglandin dehydrogenase (NAD+) activity
	ATPase activity, coupled to transmembrane movement of substances
	drug transmembrane transporter activity

GO Cellular Component	membrane
	platelet dense granule membrane
	basolateral plasma membrane
	integral to membrane
	plasma membrane

GO Biological Process	transmembrane transport
	positive regulation of smooth muscle cell proliferation
	platelet activation
	platelet degranulation
	ATP catabolic process
	drug transmembrane transport
	response to organic substance
	response to drug
	response to organic nitrogen
	response to organic cyclic compound
	blood coagulation

Pathway	paracetamol pharmacokinetics pathway

Group	Organic anions transport
	transmembrane transport
	positive regulation of smooth muscle cell proliferation
	platelet activation
	platelet degranulation
	ATP catabolic process
	drug transmembrane transport
	response to organic substance
	response to drug
	response to organic nitrogen
	response to organic cyclic compound
	blood coagulation
	nucleotide binding
	ATP binding
	15-hydroxyprostaglandin dehydrogenase (NAD+) activity
	ATPase activity, coupled to transmembrane movement of substances
	drug transmembrane transporter activity
	membrane
	platelet dense granule membrane
	basolateral plasma membrane
	integral to membrane
	plasma membrane
	Secreted proteins
	Biofluids assayable substances

MedScan ID	10257

Hugo ID	55

Human chromosome position	13q32

Alias	MRP4
	MOATB
	MOAT-B
	EST170205
	RP11-74A12.1
	multidrug resistance-associated protein 4
	MRP/cMOAT-related ABC transporter
	multispecific organic anion transporter B
	ATP-binding cassette sub-family C member 4
	multi-specific organic anion transporter B
	bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4)
	canalicular multispecific organic anion transporter (ABC superfamily)
	D630049P08Rik
	ATP-binding cassette, sub-family C (CFTR/MRP), member 4
	ABC-tranporter
	ATP-binding cassette protein C4
	D630049P08
	OTTHUMP00000018560
	Multidrug resistance-associated protein IV
	Abcc4
	ATP-binding cassette transporter C (CFTR/MRP) 4
	ATP-binding cassette transporter C (CFTR/MRP) IV
	ATP-binding cassette transporter C 4
	ATP-binding cassette transporter C IV
	ATP-binding cassette, sub-family C (CFTR/MRP), member IV
	ATP-binding cassette, sub-family c (cftr\/mrp), member 4
	ATP-binding cassette, sub-family c (cftr\/mrp), member IV
	ATP-binding cassette, sub-family C, member 4
	ATP-binding cassette, sub-family C, member IV
	ba464i2.1 (atp-binding cassette, sub-family c

OMIM ID	605250

Swiss-Prot ID	MRP4_HUMAN

Cell Localization	Membrane
	Plasma membrane

Mouse chromosome position	14

Rat chromosome position	15q24

Homologene ID	74563

MGI ID	2443111

RGD ID	620266

Primary Cell Localization	Plasma membrane