Protein Cyp2e1

URN	urn:agi-llid:1571
Total Entities	0
Connectivity	1188
Name	Cyp2e1
Description	cytochrome P450, family 2, subfamily E, polypeptide 1
Notes	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008]

Ariadne Ontology	Leukotriene synthesis
	Secreted proteins
	Biofluids assayable substances

GO Molecular Function	electron carrier activity
	oxygen binding
	enzyme binding
	FMN binding
	heme binding
	metal ion binding
	iron ion binding
	oxidoreductase activity
	monooxygenase activity
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen

GO Cellular Component	membrane
	Golgi membrane
	endoplasmic reticulum membrane
	intrinsic to endoplasmic reticulum membrane
	mitochondrion
	endoplasmic reticulum
	intracellular membrane-bounded organelle

GO Biological Process	heterocycle metabolic process
	xenobiotic metabolic process
	drug metabolic process
	triglyceride metabolic process
	monoterpenoid metabolic process
	response to drug
	response to ozone
	response to organic nitrogen
	response to ethanol
	steroid metabolic process
	oxidation-reduction process
	small molecule metabolic process

Pathway	Arachidonic acid metabolism
	Vitamin A (retinol) metabolism and visual cycle
	Acetaminophen-Induced Hepatotoxicity
	New Pathway (2)
	paracetamol pharmacokinetics pathway

Group	Leukotriene synthesis
	heterocycle metabolic process
	xenobiotic metabolic process
	drug metabolic process
	triglyceride metabolic process
	monoterpenoid metabolic process
	response to drug
	response to ozone
	response to organic nitrogen
	response to ethanol
	steroid metabolic process
	oxidation-reduction process
	small molecule metabolic process
	electron carrier activity
	oxygen binding
	enzyme binding
	FMN binding
	heme binding
	metal ion binding
	iron ion binding
	oxidoreductase activity
	monooxygenase activity
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen
	membrane
	Golgi membrane
	endoplasmic reticulum membrane
	intrinsic to endoplasmic reticulum membrane
	mitochondrion
	endoplasmic reticulum
	intracellular membrane-bounded organelle
	Secreted proteins
	Biofluids assayable substances

MedScan ID	1571

Hugo ID	2631

Human chromosome position	10q24.3-qter

Alias	CPE1
	CYP2E
	P450-J
	P450C2E
	cytochrome P450 2E1
	CYPIIE1
	cytochrome P450-J
	microsomal monooxygenase
	xenobiotic monooxygenase
	4-nitrophenol 2-hydroxylase
	flavoprotein-linked monooxygenase
	cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1
	cytochrome P450-ALC
	cytochrome P450, 2e1, ethanol inducible
	P450RLM6
	cytochrome P450RLM6
	cytochrome P450, subfamily 2E, polypeptide 1
	cytochrome P450 subfamily 2e1 (ethanol-inducible)
	Cyp2e-1
	cytochrome P450 IIE1
	cytochrome P4502E1
	cytochrome P4502e1 (ethanol-inducible)
	OTTHUMP00000020813
	OTTHUMP00000046571
	P450 (CYP) 2E1
	P450 2E1
	P4502E1
	cytochrome P450 IIE I
	P450-Js
	Cyp2e1
	cytochrome P450 IIE ethanol-inducible I
	CPE I
	Cyp2e I
	CYPIIE I
	cytochrome P450 2E
	cytochrome P450 IIE (ethanol-inducible)
	cytochrome P450 2e1 (ethanol-inducible)
	cytochrome P450 CYP2E I
	cytochrome P450 CYP2E1
	cytochrome P450 2E I
	cytochrome P450 IIE ethanol-inducible 1

OMIM ID	124040

EC Number	1.14.13.n7
	1.14.13.-

Cell Localization	Endoplasmic reticulum membrane
	Microsome membrane
	Plasma membrane

Mouse chromosome position	7 68.4 cM

Rat chromosome position	1q41-q42

Homologene ID	68089

MGI ID	88607

RGD ID	2475

Primary Cell Localization	Plasma membrane