| URN | urn:agi-llid:445329 |
|---|---|
| Total Entities | 0 |
| Connectivity | 51 |
| Name | SULT1A4 |
| Description | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 |
| Notes | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16, this gene and SULT1A3 arose from a segmental duplication. Read-through transcription exists between this gene and the upstream SLX1B (SLX1 structure-specific endonuclease subunit homolog B) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010] |
| Ariadne Ontology | Biofluids assayable substances |
|---|
| GO Molecular Function | sulfotransferase activity |
|---|---|
| aryl sulfotransferase activity |
| GO Cellular Component | cytoplasm |
|---|---|
| cytosol |
| GO Biological Process | endoplasmic reticulum unfolded protein response |
|---|---|
| activation of signaling protein activity involved in unfolded protein response | |
| xenobiotic metabolic process | |
| 3'-phosphoadenosine 5'-phosphosulfate metabolic process | |
| sulfation | |
| flavonoid metabolic process | |
| catecholamine metabolic process | |
| steroid metabolic process | |
| small molecule metabolic process |
| Pathway | New Pathway (2) |
|---|---|
| paracetamol pharmacokinetics pathway |
| Group | endoplasmic reticulum unfolded protein response |
|---|---|
| activation of signaling protein activity involved in unfolded protein response | |
| xenobiotic metabolic process | |
| 3'-phosphoadenosine 5'-phosphosulfate metabolic process | |
| sulfation | |
| flavonoid metabolic process | |
| catecholamine metabolic process | |
| steroid metabolic process | |
| small molecule metabolic process | |
| sulfotransferase activity | |
| aryl sulfotransferase activity | |
| cytoplasm | |
| cytosol | |
| Biofluids assayable substances |
| MedScan ID | 445329 |
|---|
| Hugo ID | 30004 |
|---|---|
| 11455 |
| LocusLink ID | 445329 |
|---|
| Alias | HAST3 |
|---|---|
| M-PST | |
| TL-PST | |
| ST1A3/ST1A4 | |
| sulfotransferase 1A3/1A4 | |
| sulfokinase | |
| aryl sulfotransferase 1A3/1A4 | |
| placental estrogen sulfotransferase | |
| thermolabile phenol sulfotransferase | |
| sulfotransferase, monoamine-preferring | |
| monoamine-sulfating phenol sulfotransferase | |
| catecholamine-sulfating phenol sulfotransferase | |
| STM | |
| phenol sulfotransferase | |
| sulfotransferase family, cytosolic, 1a, phenol-preferring, member 4 | |
| sulfotransferase family, cytosolic, 1a, phenol-preferring, member IV | |
| sult1a4 |
| Organism | Homo sapiens |
|---|
| Unigene ID | Hs.460558 |
|---|
| KEGG ID | hsa:445329 |
|---|---|
| hsa:6818 |
| Swiss-Prot Accession | P50224 |
|---|---|
| Q1ET61 | |
| B4DNV0 | |
| O95603 | |
| Q6ZWJ5 |
| EC Number | 2.8.2.1 |
|---|
| GO ID | 0004062 |
|---|---|
| 0008146 | |
| 0050427 | |
| 0006987 | |
| 0006584 | |
| 0030968 | |
| 0009812 | |
| 0044281 | |
| 0008202 | |
| 0051923 | |
| 0006805 | |
| 0005737 | |
| 0005829 |
| PIR ID | A55451 |
|---|
| Swiss-Prot ID | ST1A3_HUMAN |
|---|
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00030730 |
|---|---|
| IPI00446834 |
| RGD ID | 1604886 |
|---|