| URN | urn:agi-llid:54578 |
|---|---|
| Total Entities | 0 |
| Connectivity | 203 |
| Name | UGT1A6 |
| Description | UDP glucuronosyltransferase 1 family, polypeptide A6 |
| Notes | This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Heme oxidation |
|---|---|
| Steroid metabolism | |
| Glucose metabolism | |
| Biofluids assayable substances |
| GO Molecular Function | protein complex binding |
|---|---|
| enzyme binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| retinoic acid binding | |
| glucuronosyltransferase activity |
| GO Cellular Component | endoplasmic reticulum membrane |
|---|---|
| mitochondrial inner membrane | |
| integral to membrane | |
| protein complex | |
| intracellular membrane-bounded organelle |
| GO Biological Process | metabolic process |
|---|---|
| xenobiotic metabolic process | |
| glucuronate metabolic process | |
| 4-chlorobiphenyl metabolic process | |
| cellular response to hormone stimulus | |
| cellular response to glucocorticoid stimulus | |
| response to organic cyclic compound | |
| response to lipopolysaccharide | |
| response to peptide hormone stimulus | |
| liver development | |
| small molecule metabolic process |
| Pathway | PRL-GHR/NF-kB/ELK-SRF/MYC Expression Targets |
|---|---|
| PRL-GHR/STAT Expression Targets | |
| PRL-PRLR Expression Targets | |
| New Pathway (2) | |
| paracetamol pharmacokinetics pathway |
| Group | Heme oxidation |
|---|---|
| Steroid metabolism | |
| Glucose metabolism | |
| metabolic process | |
| xenobiotic metabolic process | |
| glucuronate metabolic process | |
| 4-chlorobiphenyl metabolic process | |
| cellular response to hormone stimulus | |
| cellular response to glucocorticoid stimulus | |
| response to organic cyclic compound | |
| response to lipopolysaccharide | |
| response to peptide hormone stimulus | |
| liver development | |
| small molecule metabolic process | |
| protein complex binding | |
| enzyme binding | |
| protein homodimerization activity | |
| protein heterodimerization activity | |
| retinoic acid binding | |
| glucuronosyltransferase activity | |
| endoplasmic reticulum membrane | |
| mitochondrial inner membrane | |
| integral to membrane | |
| protein complex | |
| intracellular membrane-bounded organelle | |
| Biofluids assayable substances |
| MedScan ID | 54578 |
|---|
| Hugo ID | 12538 |
|---|
| Human chromosome position | 2q37 |
|---|
| LocusLink ID | 54578 |
|---|---|
| 94284 | |
| 394435 | |
| 113992 |
| Alias | GNT1 |
|---|---|
| UGT1 | |
| HLUGP | |
| UDPGT | |
| UGT1F | |
| HLUGP1 | |
| UGT1A6S | |
| UDPGT 1-6 | |
| UDP-glucuronosyltransferase 1-6 | |
| UGT-1F | |
| UGT1*6 | |
| UGT1.6 | |
| UGT1-06 | |
| UDP-glucuronosyltransferase 1-F | |
| UDP-glucuronosyltransferase 1A6 | |
| phenol-metabolizing UDP-glucuronosyltransferase | |
| UDP glycosyltransferase 1 family, polypeptide A6 | |
| UDP-glucuronosyltransferase 1 family polypeptide A6s | |
| Ugt1a6 | |
| Ugt1a7 | |
| phenol UDP-glucuronosyltransferase | |
| A9' | |
| Ugt1a9 | |
| UDP glucuronosyltransferase 1 family, polypeptide A6B | |
| UDP glycosyltransferase 1 family polypeptide A9 | |
| A1 | |
| P-nitrophenol specific | |
| P-nitrophenol-specific UDPGT | |
| UDP glucuronosyltransferase 1A6 | |
| UDP glycosyltransferase UGT1A6 | |
| UDP-glucuronosyltransferase 1-6 precursor, microsomal | |
| UGP1A1 | |
| UGT1A6a | |
| UGT1A6b | |
| UDP glucuronosyltransferase 1 family, polypeptide A6A | |
| MGC29860 | |
| HLUGP I | |
| MGC124929 | |
| MGC36247 | |
| OTTHUMP00000065199 | |
| OTTHUMP00000199449 | |
| OTTHUMP00000199450 | |
| P-nitrophenol specific UDPGT | |
| UDP glucuronosyltransferase 1 family, polypeptide A6 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 606431 |
|---|
| Unigene ID | Hs.554822 |
|---|---|
| Mm.300095 | |
| Rn.26489 |
| KEGG ID | hsa:54578 |
|---|---|
| mmu:94284 | |
| mmu:394435 | |
| rno:113992 |
| Swiss-Prot Accession | P19224 |
|---|---|
| Q5DSZ8 | |
| A6NKK6 | |
| Q5DT01 | |
| Q64435 | |
| P08430 | |
| Q63662 | |
| Q6T5E9 | |
| Q96TE7 | |
| P70692 | |
| Q62580 | |
| Q6XL47 |
| EC Number | 2.4.1.17 |
|---|
| GO ID | 0019899 |
|---|---|
| 0015020 | |
| 0046982 | |
| 0042803 | |
| 0001972 | |
| 0008152 | |
| 0044281 | |
| 0006805 | |
| 0005789 | |
| 0016021 | |
| 0043231 | |
| 0032403 | |
| 0018880 | |
| 0071385 | |
| 0019585 | |
| 0005743 | |
| 0043234 | |
| 0032870 | |
| 0001889 | |
| 0032496 | |
| 0014070 | |
| 0043434 |
| PIR ID | A31340 |
|---|---|
| A24600 | |
| A55788 |
| Swiss-Prot ID | UD16_HUMAN |
|---|---|
| UD16_RAT | |
| UD16_MOUSE |
| Cell Localization | Microsome |
|---|---|
| Endoplasmic reticulum membrane | |
| Cytoplasm | |
| Mitochondria |
| IPI ID | IPI00451965 |
|---|---|
| IPI00475707 | |
| IPI00134432 |
| Mouse chromosome position | 1 |
|---|
| Rat chromosome position | 9q35 |
|---|
| MGI ID | 2137698 |
|---|---|
| 3580629 |
| RGD ID | 1349499 |
|---|
| Primary Cell Localization | Cytoplasm |
|---|---|
| Mitochondria |