| URN | urn:agi-llid:9429 |
|---|---|
| Total Entities | 0 |
| Connectivity | 853 |
| Name | Abcg2 |
| Description | ATP-binding cassette, sub-family G (WHITE), member 2 |
| Notes | The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. |
| Ariadne Ontology | Xenobiotic clearance |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | transporter activity |
|---|---|
| protein homodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| nucleoside-triphosphatase activity | |
| ATPase activity | |
| ATPase activity, coupled to transmembrane movement of substances | |
| xenobiotic-transporting ATPase activity | |
| heme transporter activity | |
| drug transmembrane transporter activity |
| GO Cellular Component | membrane |
|---|---|
| apical plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| nucleus |
| GO Biological Process | transmembrane transport |
|---|---|
| urate metabolic process | |
| drug transmembrane transport | |
| cellular iron ion homeostasis | |
| response to drug | |
| response to iron ion | |
| response to folic acid | |
| response to glucocorticoid stimulus | |
| embryonic process involved in female pregnancy | |
| transport | |
| drug transport | |
| heme transport | |
| drug export | |
| small molecule metabolic process |
| Pathway | DLL1 Expression Targets |
|---|---|
| DLL4 Expression Targets | |
| PRL-GHR/STAT Expression Targets | |
| PRL-PRLR Expression Targets | |
| NOTCH Expression Targets | |
| EGF/AP-1/ATF Expression Targets | |
| EGF/CREB/CREBBP/ELK-SRF/MYC Expression Targets | |
| EGF/MEF/MYOD/NFATC Expression Targets | |
| EGF/STAT Expression Targets | |
| EGF/CTNN Expression Targets | |
| gefitinib pharmacokinetics pathway | |
| statin pharmacokinetics pathway | |
| paracetamol pharmacokinetics pathway |
| Group | Xenobiotic clearance |
|---|---|
| transmembrane transport | |
| urate metabolic process | |
| drug transmembrane transport | |
| cellular iron ion homeostasis | |
| response to drug | |
| response to iron ion | |
| response to folic acid | |
| response to glucocorticoid stimulus | |
| embryonic process involved in female pregnancy | |
| transport | |
| drug transport | |
| heme transport | |
| drug export | |
| small molecule metabolic process | |
| transporter activity | |
| protein homodimerization activity | |
| nucleotide binding | |
| ATP binding | |
| nucleoside-triphosphatase activity | |
| ATPase activity | |
| ATPase activity, coupled to transmembrane movement of substances | |
| xenobiotic-transporting ATPase activity | |
| heme transporter activity | |
| drug transmembrane transporter activity | |
| membrane | |
| apical plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| nucleus | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 9429 |
|---|---|
| 619542 |
| Hugo ID | 74 |
|---|
| Human chromosome position | 4q22 |
|---|
| LocusLink ID | 9429 |
|---|---|
| 26357 | |
| 312382 | |
| 619542 |
| Alias | MRX |
|---|---|
| MXR | |
| ABCP | |
| BCRP | |
| BMDP | |
| MXR1 | |
| ABC15 | |
| BCRP1 | |
| CD338 | |
| GOUT1 | |
| CDw338 | |
| UAQTL1 | |
| EST157481 | |
| ATP-binding cassette sub-family G member 2 | |
| ABC transporter | |
| placenta specific MDR protein | |
| breast cancer resistance protein | |
| ATP-binding cassette transporter G2 | |
| mitoxantrone resistance-associated protein | |
| placenta-specific ATP-binding cassette transporter | |
| multi drug resistance efflux transport ATP-binding cassette sub-family G (WHITE) member 2 | |
| AI428558 | |
| mitoxantrone resistance protein 1 | |
| breast cancer resistance protein 1 homolog | |
| ATP-binding cassette protein G2 | |
| ATP-binding cassette, sub-family G (WHITE), member 2 | |
| Placenta-specific ATP- binding cassette transporter | |
| MGC102821 | |
| mitoxantrone resistance protein | |
| mitoxantrone resistance protein I | |
| MXR I | |
| OTTMUSP00000025071 | |
| BMDP/BCRP | |
| OTTMUSP00000025391 | |
| ATP-binding cassette transporter G (WHITE) II | |
| ABC transporter ABCG2 | |
| Abcg2 | |
| ATP-binding cassette, sub-family G, member 2 | |
| ATP-binding cassette transporter G (WHITE) 2 | |
| ATP-binding cassette transporter G 2 | |
| ATP-binding cassette transporter G II | |
| ATP-binding cassette, sub-family G (WHITE), member II | |
| ATP-binding cassette, sub-family G, member II | |
| gout susceptibility 1 | |
| ATP-binding cassette sub-family G (WHITE) member 2 | |
| expressed sequence AI428558 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 603756 |
|---|---|
| 614490 | |
| 138900 |
| Unigene ID | Hs.480218 |
|---|---|
| Mm.333096 | |
| Rn.13131 |
| KEGG ID | hsa:9429 |
|---|---|
| mmu:26357 | |
| rno:312382 |
| Swiss-Prot Accession | Q9UNQ0 |
|---|---|
| Q7TMS5 | |
| Q80W57 | |
| Q9R004 | |
| Q9Z1T0 | |
| A0A1W3 | |
| A8K1T5 | |
| O95374 | |
| Q53ZQ1 | |
| Q569L4 | |
| Q5YLG4 | |
| Q86V64 | |
| Q8IX16 | |
| Q96LD6 | |
| Q96TA8 | |
| Q9BY73 | |
| Q9NUS0 | |
| Q80ST1 | |
| Q80UR3 | |
| Q80XF3 | |
| Q4W5I3 | |
| Q8WZ76 | |
| Q3UQE4 |
| GO ID | 0005524 |
|---|---|
| 0042626 | |
| 0015232 | |
| 0042803 | |
| 0005215 | |
| 0008559 | |
| 0006879 | |
| 0006855 | |
| 0015886 | |
| 0042493 | |
| 0044281 | |
| 0055085 | |
| 0006810 | |
| 0046415 | |
| 0016021 | |
| 0005886 | |
| 0016887 | |
| 0015238 | |
| 0017111 | |
| 0000166 | |
| 0046618 | |
| 0015893 | |
| 0060136 | |
| 0016324 | |
| 0016020 | |
| 0005634 | |
| 0051593 | |
| 0051384 | |
| 0010039 | |
| 0005515 | |
| 0046983 |
| Swiss-Prot ID | ABCG2_MOUSE |
|---|---|
| ABCG2_HUMAN | |
| ABCG2_RAT |
| Cell Localization | Cell membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00468691 |
|---|---|
| IPI00298214 | |
| IPI00607625 | |
| IPI00327093 | |
| IPI00652698 | |
| IPI00831433 | |
| IPI00831631 |
| Mouse chromosome position | 6 28.5 cM |
|---|
| Rat chromosome position | 4q24 |
|---|
| Homologene ID | 55852 |
|---|
| MGI ID | 1347061 |
|---|
| RGD ID | 631345 |
|---|---|
| 1352615 |
| Primary Cell Localization | Plasma membrane |
|---|