| URN | urn:agi-llid:6818 |
|---|---|
| Total Entities | 0 |
| Connectivity | 53 |
| Name | SULT1A3 |
| Description | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 |
| Notes | Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains. [provided by RefSeq, Nov 2010] |
| GO Molecular Function | protein homodimerization activity |
|---|---|
| nucleotide binding | |
| 3'-phosphoadenosine 5'-phosphosulfate binding | |
| transferase activity | |
| sulfotransferase activity | |
| flavonol 3-sulfotransferase activity | |
| tyrosine-ester sulfotransferase activity | |
| steroid sulfotransferase activity | |
| aryl sulfotransferase activity |
| GO Cellular Component | cytosol |
|---|
| GO Biological Process | metabolic process |
|---|---|
| xenobiotic metabolic process | |
| drug metabolic process | |
| sulfation | |
| flavonoid metabolic process | |
| 4-nitrophenol metabolic process | |
| catecholamine metabolic process | |
| estrogen metabolic process | |
| response to chemical stimulus | |
| response to stress | |
| response to glucocorticoid stimulus | |
| regulation of blood pressure |
| Pathway | New Pathway (2) |
|---|---|
| paracetamol pharmacokinetics pathway |
| Group | metabolic process |
|---|---|
| xenobiotic metabolic process | |
| drug metabolic process | |
| sulfation | |
| flavonoid metabolic process | |
| 4-nitrophenol metabolic process | |
| catecholamine metabolic process | |
| estrogen metabolic process | |
| response to chemical stimulus | |
| response to stress | |
| response to glucocorticoid stimulus | |
| regulation of blood pressure | |
| protein homodimerization activity | |
| nucleotide binding | |
| 3'-phosphoadenosine 5'-phosphosulfate binding | |
| transferase activity | |
| sulfotransferase activity | |
| flavonol 3-sulfotransferase activity | |
| tyrosine-ester sulfotransferase activity | |
| steroid sulfotransferase activity | |
| aryl sulfotransferase activity | |
| cytosol |
| MedScan ID | 6818 |
|---|
| Hugo ID | 11455 |
|---|
| Human chromosome position | 16p11.2 |
|---|
| LocusLink ID | 6818 |
|---|---|
| 20887 | |
| 83783 |
| Alias | STM |
|---|---|
| HAST | |
| HAST3 | |
| M-PST | |
| ST1A5 | |
| TL-PST | |
| ST1A3/ST1A4 | |
| sulfotransferase 1A3/1A4 | |
| sulfokinase | |
| phenol sulfotransferase 1A5 | |
| aryl sulfotransferase 1A3/1A4 | |
| dopamine-specific sulfotransferase | |
| placental estrogen sulfotransferase | |
| monoamine-sulfating phenosulfotransferase | |
| catecholamine-sulfating phenol sulfotransferase | |
| thermolabile (monoamine, M form) phenol sulfotransferase | |
| PST | |
| Stp | |
| Stp1 | |
| ST1A1 | |
| AI266890 | |
| sulfotransferase 1A1 | |
| ST1A4 | |
| mSTp1 | |
| aryl sulfotransferase | |
| phenol sulfotransferase | |
| arylsulfotransferase ST1A4 | |
| phenol/aryl sulfotransferase | |
| sulfotransferase, phenol preferring 1 | |
| ASTIV | |
| Mx-ST | |
| PST-1 | |
| Sult1a3 | |
| aryl sulfotransferase IV | |
| minoxidil sulfotransferase | |
| Phenol sulfotransferase 1a1 | |
| tyrosine-ester sulfotransferase | |
| sulfotransferase family 1A, phenol-preferring, member 1 | |
| sulfotransferase family, cytosolic, 1A, phenol preferring | |
| Aryl sulfotransferase cytosolic 1A phenol-preferring member 3 | |
| sulphotransferase family cytosolic 1A phenol-prefering member 1 | |
| Aryl sulfotransferase cytosolic, 1A, phenol-preferring, member 3 | |
| phenol sulfotransferase 1A5*4 | |
| placental oestrogen sulfotransferase | |
| OTTHUMP00000045747 | |
| sulfotransferase family 1A, phenol-preferring, member 3 | |
| sulfotransferase family 1A, phenol-preferring, member III | |
| sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 | |
| sulfotransferase family, cytosolic, 1A, phenol-preferring, member III | |
| Sulfotransferase, monoamine-preferring | |
| Thermolabile phenol sulfotransferase | |
| cytosolic sulfotransferase family, 1A, phenol-preferring, member 3 | |
| OTTHUMP00000045746 | |
| cytosolic sulfotransferase family, 1A, phenol-preferring, member III | |
| M form phenol sulfotransferase | |
| MGC117469 | |
| monoamine-preferring sulfotransferase | |
| Monoamine-sulfating phenol sulfotransferase | |
| LOC648394 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 600641 |
|---|
| Unigene ID | Hs.460558 |
|---|---|
| Hs.741198 | |
| Mm.368982 | |
| Rn.1507 |
| KEGG ID | hsa:6818 |
|---|---|
| mmu:20887 | |
| rno:83783 |
| Swiss-Prot Accession | P50224 |
|---|---|
| Q1ET61 | |
| Q91W19 | |
| P52840 | |
| P17988 | |
| Q548D2 |
| EC Number | 2.8.2.1 |
|---|
| GO ID | 0050656 |
|---|---|
| 0004062 | |
| 0047894 | |
| 0000166 | |
| 0042803 | |
| 0050294 | |
| 0008146 | |
| 0016740 | |
| 0017067 | |
| 0018960 | |
| 0006584 | |
| 0017144 | |
| 0008210 | |
| 0009812 | |
| 0008152 | |
| 0042221 | |
| 0051384 | |
| 0006950 | |
| 0051923 | |
| 0006805 | |
| 0005829 | |
| 0008217 |
| PIR ID | S10329 |
|---|
| Swiss-Prot ID | ST1A1_RAT |
|---|
| Cell Localization | Cytoplasm |
|---|
| IPI ID | IPI00193049 |
|---|
| Mouse chromosome position | 7 4.0 cM |
|---|
| Rat chromosome position | 1q35-q37 |
|---|
| MGI ID | 102896 |
|---|
| RGD ID | 1347398 |
|---|