Protein Abcc3

URN	urn:agi-llid:8714
Total Entities	0
Connectivity	290
Name	Abcc3
Description	ATP-binding cassette, sub-family C (CFTR/MRP), member 3
Notes	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

Ariadne Ontology	Organic anions transport
	Secreted proteins
	Biofluids assayable substances

GO Molecular Function	transporter activity
	nucleotide binding
	ATP binding
	nucleoside-triphosphatase activity
	ATPase activity
	ATPase activity, coupled to transmembrane movement of substances
	xenobiotic-transporting ATPase activity
	bile acid-exporting ATPase activity
	organic anion transmembrane transporter activity
	drug transmembrane transporter activity

GO Cellular Component	membrane
	basolateral plasma membrane
	integral to plasma membrane
	integral to membrane
	plasma membrane

GO Biological Process	transmembrane transport
	ATP catabolic process
	bile acid metabolic process
	drug transmembrane transport
	response to organic substance
	response to organic nitrogen
	response to organic cyclic compound
	response to lipopolysaccharide
	response to estradiol stimulus
	transport
	drug transport
	organic anion transport
	bile acid and bile salt transport
	canalicular bile acid transport
	small molecule metabolic process

Pathway	paracetamol pharmacokinetics pathway

Group	Organic anions transport
	transmembrane transport
	ATP catabolic process
	bile acid metabolic process
	drug transmembrane transport
	response to organic substance
	response to organic nitrogen
	response to organic cyclic compound
	response to lipopolysaccharide
	response to estradiol stimulus
	transport
	drug transport
	organic anion transport
	bile acid and bile salt transport
	canalicular bile acid transport
	small molecule metabolic process
	transporter activity
	nucleotide binding
	ATP binding
	nucleoside-triphosphatase activity
	ATPase activity
	ATPase activity, coupled to transmembrane movement of substances
	xenobiotic-transporting ATPase activity
	bile acid-exporting ATPase activity
	organic anion transmembrane transporter activity
	drug transmembrane transporter activity
	membrane
	basolateral plasma membrane
	integral to plasma membrane
	integral to membrane
	plasma membrane
	Secreted proteins
	Biofluids assayable substances

MedScan ID	8714

Hugo ID	54

Human chromosome position	17q22

Alias	MLP2
	MRP3
	ABC31
	MOAT-D
	cMOAT2
	EST90757
	canalicular multispecific organic anion transporter 2
	multidrug resistance associated protein
	multidrug resistance-associated protein 3
	ATP-binding cassette sub-family C member 3
	multi-specific organic anion transporter D
	canicular multispecific organic anion transporter
	1700019L09Rik
	RP23-65I14.2
	transporter
	ATP-binding cassette protein C3
	ATP-binding cassette transporter
	MLP-2
	MRP-like protein 2
	organic anion transporter
	multidrug resistance protein 3
	ATP-binding cassette, sub-family C (CFTR/MRP), member 3
	Canalicular multispecific organic anion transporter II
	Multidrug resistance-associated protein III
	DKFZp686E22157
	mrp3a
	mrp3b
	OTTMUSP00000001838
	ATP-binding cassette, sub-family c, member III
	Abcc3
	ATP-binding cassette, sub-family C, member 3 MRP3B
	ATP-binding cassette transporter C (CFTR/MRP) 3
	ATP-binding cassette transporter C (CFTR/MRP) III
	ATP-binding cassette transporter C 3
	ATP-binding cassette transporter C 3 MRP3
	ATP-binding cassette transporter C 3 MRP3A
	ATP-binding cassette, sub-family C, member 3 MRP3
	1700019L09
	ATP-binding cassette transporter C 3 MRP3B
	ATP-binding cassette, sub-family C, member 3 MRP3A
	ATP-binding cassette, sub-family c, member 3
	ATP-binding cassette, sub-family c (cftr\/mrp), member III
	ATP-binding cassette, sub-family c (cftr\/mrp), member 3
	ATP-binding cassette, sub-family C (CFTR/MRP), member III
	ATP-binding cassette transporter C III

OMIM ID	604323

PIR ID	JE0336

Cell Localization	Membrane
	Plasma membrane

Mouse chromosome position	11

Rat chromosome position	10q26

Homologene ID	68364

MGI ID	1923658

RGD ID	71101

Primary Cell Localization	Plasma membrane