| URN | urn:agi-llid:1244 |
|---|---|
| Total Entities | 0 |
| Connectivity | 800 |
| Name | Abcc2 |
| Description | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 |
| Notes | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. |
| Ariadne Ontology | Organic anions transport |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | transporter activity |
|---|---|
| protein domain specific binding | |
| nucleotide binding | |
| ATP binding | |
| nucleoside-triphosphatase activity | |
| ATPase activity | |
| ATPase activity, coupled to transmembrane movement of substances | |
| organic anion transmembrane transporter activity |
| GO Cellular Component | membrane |
|---|---|
| apical plasma membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| intercellular canaliculus |
| GO Biological Process | metabolic process |
|---|---|
| transmembrane transport | |
| ATP catabolic process | |
| drug transmembrane transport | |
| cellular chloride ion homeostasis | |
| response to drug | |
| response to arsenic-containing substance | |
| response to steroid hormone stimulus | |
| response to estrogen stimulus | |
| response to methotrexate | |
| response to oxidative stress | |
| response to heat | |
| transport | |
| organic anion transport | |
| thyroid hormone transport | |
| prostaglandin transport |
| Pathway | statin pharmacokinetics pathway |
|---|---|
| statin pharmacokinetics pathway | |
| paracetamol pharmacokinetics pathway |
| Group | Organic anions transport |
|---|---|
| metabolic process | |
| transmembrane transport | |
| ATP catabolic process | |
| drug transmembrane transport | |
| cellular chloride ion homeostasis | |
| response to drug | |
| response to arsenic-containing substance | |
| response to steroid hormone stimulus | |
| response to estrogen stimulus | |
| response to methotrexate | |
| response to oxidative stress | |
| response to heat | |
| transport | |
| organic anion transport | |
| thyroid hormone transport | |
| prostaglandin transport | |
| transporter activity | |
| protein domain specific binding | |
| nucleotide binding | |
| ATP binding | |
| nucleoside-triphosphatase activity | |
| ATPase activity | |
| ATPase activity, coupled to transmembrane movement of substances | |
| organic anion transmembrane transporter activity | |
| membrane | |
| apical plasma membrane | |
| integral to plasma membrane | |
| integral to membrane | |
| plasma membrane | |
| intercellular canaliculus | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 1244 |
|---|---|
| 25303 |
| Hugo ID | 53 |
|---|
| Human chromosome position | 10q24 |
|---|
| LocusLink ID | 1244 |
|---|---|
| 12780 | |
| 25303 |
| Alias | DJS |
|---|---|
| MRP2 | |
| cMRP | |
| ABC30 | |
| CMOAT | |
| RP11-114F7.2 | |
| canalicular multispecific organic anion transporter 1 | |
| canalicular multidrug resistance protein | |
| multidrug resistance-associated protein 2 | |
| ATP-binding cassette sub-family C member 2 | |
| AI173996 | |
| multidrug resistance protein 2 | |
| multidrug resistance associated protein 2 | |
| calicular multispecific organic anion transporter | |
| ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | |
| Canalicular multispecific organic anion transporter I | |
| CMOAT I | |
| CMOAT1 | |
| multidrug resistance protein II | |
| Multidrug resistance-associated protein II | |
| rMRP2 | |
| canalicular multispecific organic anion transporter | |
| ATP-binding cassette transporter C 2 | |
| OTTHUMP00000020267 | |
| Abcc2 | |
| ATP-binding cassette transporter C (CFTR/MRP) II | |
| ATP-binding cassette transporter C II | |
| ATP-binding cassette, sub-family C (CFTR/MRP), member II | |
| ATP-binding cassette, sub-family C, member 2 | |
| ATP-binding cassette, sub-family C, member II | |
| ATP-binding cassette transporter C (CFTR/MRP) 2 | |
| KIAA1010 | |
| Multidrug resistance-associated protein 2 | |
| Multidrug resistance-associated protein II | |
| CMOAT1s | |
| Canalicular multidrug resistance protein | |
| expressed sequence AI173996 | |
| CMOAT Is |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 601107 |
|---|---|
| 237500 |
| Unigene ID | Hs.368243 |
|---|---|
| Mm.39054 | |
| Rn.10265 |
| KEGG ID | hsa:1244 |
|---|---|
| mmu:12780 | |
| rno:25303 |
| Swiss-Prot Accession | Q92887 |
|---|---|
| Q8VI47 | |
| Q63120 | |
| B2RMT8 | |
| Q14022 | |
| Q5T2B1 | |
| Q92500 | |
| Q92798 | |
| Q99663 | |
| Q9UMS2 | |
| Q63145 | |
| Q8VI46 | |
| Q5TCZ5 | |
| Q9UN90 | |
| Q9ESU2 | |
| Q9JIH8 | |
| Q9JL42 |
| GO ID | 0005524 |
|---|---|
| 0042626 | |
| 0008514 | |
| 0015711 | |
| 0055085 | |
| 0006810 | |
| 0016324 | |
| 0005887 | |
| 0046581 | |
| 0005886 | |
| 0016887 | |
| 0017111 | |
| 0000166 | |
| 0019904 | |
| 0005215 | |
| 0006200 | |
| 0030644 | |
| 0006855 | |
| 0008152 | |
| 0015732 | |
| 0042493 | |
| 0070327 | |
| 0016021 | |
| 0016020 | |
| 0046685 | |
| 0043627 | |
| 0009408 | |
| 0031427 | |
| 0006979 | |
| 0048545 | |
| 0005624 | |
| 0005515 |
| PIR ID | S71841 |
|---|---|
| S71839 |
| Swiss-Prot ID | MRP2_HUMAN |
|---|---|
| MRP2_RAT | |
| MRP2_MOUSE | |
| Q8VI46_MOUSE | |
| B2RMT8_HUMAN |
| Cell Localization | Membrane |
|---|---|
| Plasma membrane |
| IPI ID | IPI00023868 |
|---|---|
| IPI00205806 | |
| IPI00420412 | |
| IPI00120580 | |
| IPI00815960 | |
| IPI00646446 |
| Mouse chromosome position | 19 43.0 cM |
|---|
| Rat chromosome position | 1q51 |
|---|
| Homologene ID | 68052 |
|---|
| MGI ID | 1352447 |
|---|
| RGD ID | 2366 |
|---|---|
| 619569 |
| Primary Cell Localization | Plasma membrane |
|---|