Elsevier Inc. Ptgs2 Ptgs1 prostanoid biosynthetic pathway ---> various responses elicited by signaling via prostanoids various responses elicited by signaling via prostanoids prostanoid biosynthetic pathway arachidonic acid PGH2 PGG2 cyclooxygenase mediated pathway of arachidonic acid metabolism paracetamol pharmacokinetics pathway arachidonic acid metabolic pathway paracetamol response pathway paracetamol paracetamol ---> paracetamol pharmacokinetics pathway arachidonic acid ---> PGG2 paracetamol --+> paracetamol response pathway PGG2 ---> PGH2 paracetamol ---| Ptgs1 paracetamol ---| Ptgs2 paracetamol ---| prostanoid biosynthetic pathway PGH2 --+> prostanoid biosynthetic pathway Pain Fever paracetamol ---| Fever paracetamol ---| Pain