| URN | urn:agi-llid:5444 |
|---|---|
| Total Entities | 0 |
| Connectivity | 733 |
| Name | Pon1 |
| Description | paraoxonase 1 |
| Notes | The enzyme encoded by this gene is an arylesterase that mainly hydrolyzes paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion. Polymorphisms in this gene are a risk factor in coronary artery disease. The gene is found in a cluster of three related paraoxonase genes at 7q21.3. [provided by RefSeq, Oct 2008] |
| Ariadne Ontology | Lipid transport |
|---|---|
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | protein homodimerization activity |
|---|---|
| phospholipid binding | |
| metal ion binding | |
| calcium ion binding | |
| high-density lipoprotein particle binding | |
| hydrolase activity | |
| arylesterase activity | |
| aryldialkylphosphatase activity |
| GO Cellular Component | extracellular region |
|---|---|
| high-density lipoprotein particle | |
| spherical high-density lipoprotein particle | |
| intracellular membrane-bounded organelle | |
| extracellular space |
| GO Biological Process | negative regulation of plasma lipoprotein particle oxidation |
|---|---|
| carboxylic acid catabolic process | |
| aromatic compound catabolic process | |
| phosphatidylcholine metabolic process | |
| organophosphate catabolic process | |
| response to external stimulus | |
| response to toxin | |
| positive regulation of transporter activity | |
| positive regulation of cholesterol efflux | |
| blood circulation | |
| lipid metabolic process | |
| cholesterol metabolic process | |
| positive regulation of binding |
| Pathway | organophosphate response pathway |
|---|
| Group | Lipid transport |
|---|---|
| negative regulation of plasma lipoprotein particle oxidation | |
| carboxylic acid catabolic process | |
| aromatic compound catabolic process | |
| phosphatidylcholine metabolic process | |
| organophosphate catabolic process | |
| response to external stimulus | |
| response to toxin | |
| positive regulation of transporter activity | |
| positive regulation of cholesterol efflux | |
| blood circulation | |
| lipid metabolic process | |
| cholesterol metabolic process | |
| positive regulation of binding | |
| protein homodimerization activity | |
| phospholipid binding | |
| metal ion binding | |
| calcium ion binding | |
| high-density lipoprotein particle binding | |
| hydrolase activity | |
| arylesterase activity | |
| aryldialkylphosphatase activity | |
| extracellular region | |
| high-density lipoprotein particle | |
| spherical high-density lipoprotein particle | |
| intracellular membrane-bounded organelle | |
| extracellular space | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 5444 |
|---|
| Hugo ID | 9204 |
|---|
| Human chromosome position | 7q21.3 |
|---|
| LocusLink ID | 5444 |
|---|---|
| 18979 | |
| 84024 |
| Alias | ESA |
|---|---|
| PON | |
| MVCD5 | |
| serum paraoxonase/arylesterase 1 | |
| K-45 | |
| PON 1 | |
| esterase A | |
| A-esterase 1 | |
| paraoxonase B-type | |
| aromatic esterase 1 | |
| arylesterase B-type | |
| serum aryldiakylphosphatase | |
| serum aryldialkylphosphatase 1 | |
| Serum aryldialkylphosphatase I | |
| paraoxonase 1 | |
| paraoxonase B | |
| paraoxonase I | |
| phosphotriesterase 1 | |
| pirimiphos-methyloxon esterase 1 | |
| PON I | |
| PON1 | |
| paraoxon hydrolase 1 | |
| Serum paraoxonase/arylesterase I | |
| organophosphorus acid anhydrase 1 | |
| Aromatic esterase I | |
| Paraoxon esterase 1 | |
| aryldialkylphosphatase 1 | |
| arylesterase B | |
| aryltriphosphatase 1 | |
| esterase B1 | |
| organophosphate esterase 1 | |
| organophosphate hydrolase 1 | |
| organophosphorus hydrolase 1 | |
| esterase E4 | |
| A-esterase I |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 168820 |
|---|---|
| 612633 |
| Unigene ID | Hs.370995 |
|---|---|
| Mm.237657 | |
| Rn.20732 |
| KEGG ID | hsa:5444 |
|---|---|
| mmu:18979 | |
| rno:84024 |
| Swiss-Prot Accession | P27169 |
|---|---|
| P52430 | |
| P55159 | |
| B2RA40 | |
| Q16052 | |
| Q6B0J6 | |
| Q9UCB1 | |
| O08682 | |
| Q5BJN6 | |
| Q91X30 |
| EC Number | 3.1.1.81 |
|---|---|
| 3.1.1.2 | |
| 3.1.8.1 |
| GO ID | 0004063 |
|---|---|
| 0004064 | |
| 0005509 | |
| 0005543 | |
| 0042803 | |
| 0019439 | |
| 0046395 | |
| 0034445 | |
| 0046434 | |
| 0046470 | |
| 0051099 | |
| 0010875 | |
| 0032411 | |
| 0009605 | |
| 0009636 | |
| 0005576 | |
| 0005615 | |
| 0034364 | |
| 0034366 | |
| 0008035 | |
| 0016787 | |
| 0046872 | |
| 0008015 | |
| 0008203 | |
| 0043231 | |
| 0006629 |
| PIR ID | A45451 |
|---|---|
| PT0088 | |
| T10082 |
| Swiss-Prot ID | PON1_HUMAN |
|---|---|
| PON1_RAT | |
| PON1_MOUSE |
| Cell Localization | Secreted |
|---|---|
| extracellular space | |
| Plasma membrane |
| IPI ID | IPI00218732 |
|---|---|
| IPI00231264 | |
| IPI00317356 |
| Mouse chromosome position | 6 0.5 cM |
|---|
| Rat chromosome position | 4q13 |
|---|
| Homologene ID | 68058 |
|---|
| MGI ID | 103295 |
|---|
| RGD ID | 620062 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|