| URN | urn:agi-llid:1554 |
|---|---|
| Total Entities | 0 |
| Connectivity | 1036 |
| Name | CYP2B6 |
| Description | cytochrome P450, family 2, subfamily B, polypeptide 6 |
| Notes | This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] |
| Ariadne Ontology | Leukotriene synthesis |
|---|---|
| Xenobiotic clearance | |
| Secreted proteins | |
| Biofluids assayable substances |
| GO Molecular Function | electron carrier activity |
|---|---|
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity | |
| steroid hydroxylase activity |
| GO Cellular Component | endoplasmic reticulum membrane |
|---|---|
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle |
| GO Biological Process | xenobiotic metabolic process |
|---|---|
| cellular ketone metabolic process | |
| drug metabolic process | |
| nicotine metabolic process | |
| exogenous drug catabolic process | |
| response to drug | |
| response to sulfur dioxide | |
| response to metal ion | |
| response to calcium ion | |
| response to organic cyclic compound | |
| response to insulin stimulus | |
| aging | |
| steroid metabolic process | |
| oxidation-reduction process | |
| small molecule metabolic process |
| Pathway | Arachidonic acid metabolism |
|---|---|
| organophosphate response pathway |
| Group | Leukotriene synthesis |
|---|---|
| Xenobiotic clearance | |
| xenobiotic metabolic process | |
| cellular ketone metabolic process | |
| drug metabolic process | |
| nicotine metabolic process | |
| exogenous drug catabolic process | |
| response to drug | |
| response to sulfur dioxide | |
| response to metal ion | |
| response to calcium ion | |
| response to organic cyclic compound | |
| response to insulin stimulus | |
| aging | |
| steroid metabolic process | |
| oxidation-reduction process | |
| small molecule metabolic process | |
| electron carrier activity | |
| heme binding | |
| metal ion binding | |
| iron ion binding | |
| oxidoreductase activity | |
| monooxygenase activity | |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
| aromatase activity | |
| steroid hydroxylase activity | |
| endoplasmic reticulum membrane | |
| endoplasmic reticulum | |
| intracellular membrane-bounded organelle | |
| Secreted proteins | |
| Biofluids assayable substances |
| MedScan ID | 1554 |
|---|---|
| 24300 |
| Hugo ID | 2615 |
|---|
| Human chromosome position | 19q13.2 |
|---|
| LocusLink ID | 1554 |
|---|---|
| 1555 | |
| 13088 | |
| 24300 | |
| 361523 |
| Alias | CPB6 |
|---|---|
| EFVM | |
| IIB1 | |
| P450 | |
| CYP2B | |
| CYP2B7 | |
| CYP2B7P | |
| CYPIIB6 | |
| cytochrome P450 2B6 | |
| cytochrome P450 IIB1 | |
| 1,4-cineole 2-exo-monooxygenase | |
| cytochrome P450, subfamily IIB (phenobarbital-inducible), polypeptide 6 | |
| p16 | |
| Cyp2b20 | |
| cytochrome P450 2B10 | |
| P24 | |
| CYPIIB10 | |
| CYPIIB20 | |
| cytochrome P450 2B20 | |
| cytochrome P450, 2b20 | |
| cytochrome P450-16-alpha | |
| cytochrome P450 clone PF3/46 | |
| phenobarbitol inducible, type b | |
| testosterone 16-alpha hydroxylase | |
| cytochrome P450, 2b10, phenobarbitol inducible, type b | |
| cytochrome P450, family 2, subfamily b, polypeptide 20 | |
| Cypbe | |
| Cyp2b-1 | |
| cytochrome P450 2B1 | |
| P450b | |
| P450-B | |
| CYPIIB1 | |
| P450-LM2 | |
| cytochrome P450b | |
| cytochrome P450-B | |
| cytochrome P450-LM2 | |
| cytochrome P450-PB1 | |
| cytochrome P450-PB2 | |
| P450-PB1 and P450-PB2 | |
| Cytochrome P450, subfamily IIB (phenobarbital-inducible) (b, e) | |
| Cype | |
| CYPIIB2 | |
| cytochrome P450 2B2 | |
| cytochrome P450E | |
| cytochrome P-450e-M | |
| cytochrome P450 PB4 | |
| cytochrome P-450b type e | |
| cytochrome P450, subfamily IIB (phenobarbital-inducible)(b, e) | |
| Cyp2b-2 | |
| cytochrome P4502b20 | |
| P4502b2 | |
| P450 (CYP) 2b20 | |
| cytochrome P4502B6 | |
| cytochrome P4502b2 | |
| LOC361523 | |
| LOC82059 | |
| P450 (CYP) 2b10 | |
| P450 (CYP) 2b2 | |
| P450 (CYP) 2B6 | |
| P450 2b10 | |
| P450 2b2 | |
| P450 2b20 | |
| P4502b10 | |
| P4502b20 | |
| P4502B6 | |
| cytochrome P450 2b II | |
| cytochrome P4502b10 | |
| P450 2B6 | |
| Cyp2b10 | |
| cytochrome P450 2b10, phenobarbitol inducible, type b | |
| Cyp2b2 | |
| CYP2B6 | |
| cytochrome P450 IIB phenobarbital-inducible 6 | |
| cytochrome P450 IIB phenobarbital-inducible VI | |
| cytochrome P450 2b6, phenobarbitol inducible, type b | |
| P450 (CYP) 2B I | |
| P450 (CYP) IIB I | |
| P450 (CYP) IIB1 | |
| P450 2B I | |
| P450 2b1 | |
| P450 IIB I | |
| P450 IIB1 | |
| P4502b1 | |
| MGC188065 | |
| Cyp be | |
| Cyp2b I | |
| IIB I | |
| cytochrome P450 IIB (phenobarbital-inducible)(b e) | |
| Cyp b e | |
| P450 (CYP) 2b1 | |
| cytochrome P4502b1 | |
| Cyp2b1 |
| Organism | Homo sapiens |
|---|---|
| Mus musculus | |
| Rattus norvegicus |
| OMIM ID | 123930 |
|---|---|
| 614546 |
| Unigene ID | Hs.1360 |
|---|---|
| Mm.218749 | |
| Rn.228579 | |
| Rn.91353 |
| KEGG ID | hsa:1555 |
|---|---|
| mmu:13088 | |
| rno:24300 | |
| rno:361523 |
| Swiss-Prot Accession | P20813 |
|---|---|
| Q9WUD0 | |
| P12791 | |
| B2GV28 | |
| P00176 | |
| F1LSA2 | |
| P04167 | |
| Q2V565 | |
| Q9UK46 | |
| Q64579 | |
| Q64582 |
| EC Number | 1.14.14.1 |
|---|---|
| 1.14.13.- |
| GO ID | 0009055 |
|---|---|
| 0020037 | |
| 0005506 | |
| 0004497 | |
| 0016712 | |
| 0042180 | |
| 0017144 | |
| 0042738 | |
| 0055114 | |
| 0044281 | |
| 0008202 | |
| 0006805 | |
| 0005783 | |
| 0005789 | |
| 0043231 | |
| 0046872 | |
| 0016491 | |
| 0008395 | |
| 0070330 | |
| 0051592 | |
| 0042493 | |
| 0032868 | |
| 0010038 | |
| 0014070 | |
| 0010477 | |
| 0007568 | |
| 0018933 |
| PIR ID | A32969 |
|---|---|
| A21162 | |
| A60822 |
| Swiss-Prot ID | CP2B6_HUMAN |
|---|---|
| CP2B2_RAT |
| Cell Localization | Endoplasmic reticulum membrane |
|---|---|
| Microsome membrane | |
| Plasma membrane |
| IPI ID | IPI00025829 |
|---|---|
| IPI00193234 | |
| IPI00480585 |
| Mouse chromosome position | 7 6.5 cM |
|---|
| Rat chromosome position | 1 |
|---|---|
| 1q21 |
| MGI ID | 88598 |
|---|
| RGD ID | 1346751 |
|---|
| Primary Cell Localization | Plasma membrane |
|---|