Elsevier Inc. chlorpyrifos parathion pesticides Respiratory Failure Cardiovascular Failure Ache ---| acetylcholine signaling via nicotinic acetylcholine receptor Ache ---| acetylcholine signaling via muscarinic acetylcholine receptor acetylcholine signaling pathway OPCs ---> developmental neurotoxicity neuron toxicity OPCs ---> neuron toxicity diazepam atropine Ache reactivator --+> Ache OPCs ---> hydrolysis products parathion ---> paraoxon CYP2B6 paraoxon chlorpyrifos oxon OPCs acetylcholine --+> acetylcholine signaling via nicotinic acetylcholine receptor OPCs ---> Cardiovascular Failure enzyme aging ---| Ache reactivator enzyme aging ---| pralidoxime enzyme aging diazepam ---| organophosphorus poisoning symptoms acetylcholine OPCs ---> Alb paraoxon ---> Alb chlorpyrifos oxon ---> Alb Alb Pon1 chlorpyrifos ---> chlorpyrifos oxon hydrolysis products product excretion hydrolysis products ---> product excretion pralidoxime developmental neurotoxicity OPCs ---> organophosphorus poisoning symptoms Ache atropine ---| organophosphorus poisoning symptoms atropine ---| acetylcholine signaling via muscarinic acetylcholine receptor organophosphorus poisoning symptoms Ache reactivator pralidoxime --+> Ache acetylcholine --+> acetylcholine signaling pathway acetylcholine --+> acetylcholine signaling via muscarinic acetylcholine receptor paraoxon ---| Ache OPCs ---| Ache chlorpyrifos oxon ---| Ache acetylcholine signaling via nicotinic acetylcholine receptor acetylcholine signaling via muscarinic acetylcholine receptor chemical warfare ACh hydrolysis, signal termination Ache ---> ACh hydrolysis, signal termination OPCs ---> Respiratory Failure